Comfortis

Comfortis Uses, Dosage, Side Effects, Food Interaction and all others data.

Comfortis is a pediculicide mixture of spinosyn A and spinosyn D (in an approximately 5:1 ratio, respectively) used in the topical treatment of head lice in children (four years old and older) and in adults. Comfortis is an insecticide based on a compound found in S. spinosa, a bacterial species. Comfortis has also been experimented for use in cats for treatment of flea infestations, and has also been experimented for use against the KS1 Ctenocephalides felis flea strain infesting dogs, in addition to many investigations for use in other animals and agricultural plants.

Spinosyn A does not appear to directly interact with any known relevant insecticidal targets, but instead boasts a novel mechanism that resembles a GABA antagonist. Spinosyn A is also slightly more biologically active than spinosyn D.

Comfortis
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Comfortis
Availability	Prescription only
Generic	Spinosad
Spinosad Other Names	Spinosad
Related Drugs	ivermectin topical, sodium chloride topical, permethrin topical, Elimite, acetic acid topical, Natroba, Nix Cream Rinse, Lice Treatment, RID
Type	For animal use only
Formula	C₈₃H₁₃₂N₂O₂₀
Weight	Average: 1477.963 Monoisotopic: 1476.937344658
Protein binding	Not plasma protein bound if administered topically.
Groups	Approved, Investigational, Vet approved
Therapeutic Class
Manufacturer
Available Country	United States
Last Updated:	September 19, 2023 at 7:00 am

Uses

Comfortis is a pediculicide used topically to treat head lice.

Comfortis is indicated for the topical treatment of head lice in children four years old and over and in adults.

Comfortis is also used to associated treatment for these conditions: Head Lice Infestation

How Comfortis works

Comfortis is a mixture of spinosyn A and spinosyn D in a 5:1 ratio. This combination causes neuronal hyperexcitation through mostly alteration of nicotinic acetylcholine receptors, which ultimately leads to lice paralysis and death.

Toxicity

Natroba contains benzyl alcohol, which should be avoided in neonates due to associated severe adverse effects and potential fatality. For use only on the scalp and associated hair. Avoid ingestion and contact with eyes. Comfortis itself is not hazardous by the oral, dermal, ocular, or inhalational routes.