Conlax Oral Solution 3.35 gm/5 ml

Conlax Oral Solution 3.35 gm/5 ml Uses, Dosage, Side Effects, Food Interaction and all others data.

Conlax Oral Solution 3.35 gm/5 ml causes a decrease in blood ammonia concentration and reduces the degree of portal-systemic encephalopathy. These actions are considered to be results of the following:

Bacterial degradation of lactulose in the colon acidifies the colonic contents.This acidification of colonic contents results in the retention of ammonia in the colon as the ammonium ion. Since the colonic contents are then more acid than the blood, ammonia can be expected to migrate from the blood into the colon to form the ammonium ion.The acid colonic contents convert NH3 to the ammonium ion (NH4)+, trapping it and preventing its absorption.The laxative action of the metabolites of lactulose then expels the trapped ammonium ion from the colon.Experimental data indicate that lactulose is poorly absorbed. Conlax Oral Solution 3.35 gm/5 ml given orally to man and experimental animals resulted in only small amounts reaching the blood. Urinary excretion has been determined to be 3% or less and is essentially complete within 24 hours.When incubated with extracts of human small intestinal mucosa, lactulose was not hydrolyzed during a 24-hour period and did not inhibit the activity of these extracts on lactose. Conlax Oral Solution 3.35 gm/5 ml reaches the colon essentially unchanged. There it is metabolized by bacteria with the formation of low molecular weight acids that acidify the colon contents.Conlax Oral Solution 3.35 gm/5 ml formulations are most commonly administered via the oral route or the rectal route. Consequently, because the substance experiences minimal absorption by the gut it typically remains localized in the gastrointestinal tract environment and ultimately demonstrates almost all of its pharmacologic effects within the gut. In particular, as lactulose elicits its laxative effects in enhancing stool amounts and softening stool, such biochemical and physiologic activities can cause increased bowel sounds (borborygmi), a feeling of bloatedness, belching, frequent flatus, and diarrhea.

Conlax Oral Solution 3.35 gm/5 ml formulations are most commonly administered via the oral route or the rectal route. Consequently, because the substance experiences minimal absorption by the gut it typically remains localized in the gastrointestinal tract environment and ultimately demonstrates almost all of its pharmacologic effects within the gut. In particular, as lactulose elicits its laxative effects in enhancing stool amounts and softening stool, such biochemical and physiologic activities can cause increased bowel sounds (borborygmi), a feeling of bloatedness, belching, frequent flatus, and diarrhea.

Trade Name Conlax Oral Solution 3.35 gm/5 ml
Availability Prescription only
Generic Lactulose
Lactulose Other Names Lactulosa, Lactulose, Lactulosum
Related Drugs MiraLAX, Linzess, polyethylene glycol 3350, Xifaxan, Amitiza, rifaximin, neomycin, Movantik, linaclotide, lubiprostone
Weight 3.35 gm/5 ml
Type Oral Solution
Formula C12H22O11
Weight Average: 342.2965
Monoisotopic: 342.116211546
Protein binding

Negligible amounts of lactulose - metabolized or non-metabolized - are absorbed into the body.. Regardless, data regarding the protein binding of lactulose is not readily available or accessible.

Groups Approved
Therapeutic Class Osmotic purgatives
Manufacturer UniMed UniHealth Pharmaceuticals Ltd.
Available Country Bangladesh
Last Updated: October 19, 2023 at 6:27 am
Conlax Oral Solution 3.35 gm/5 ml
Conlax Oral Solution 3.35 gm/5 ml

Uses

Conlax Oral Solution 3.35 gm/5 ml is used in the treatment of chronic and habitual constipation, treatment of acute and the prevention and treatment of chronic Portal-systemic encephalopathy including the stages of hepatic pre-coma and coma.

Conlax Oral Solution 3.35 gm/5 ml is a hyperosmolar laxative which is used as an effective treatment approach for constipation. It is a non-absorbable disaccharide which draws water into the bowel; causes distention through fluid accumulation, thus promotes soft stool and accelerates bowel motion.

Conlax Oral Solution 3.35 gm/5 ml is also used to associated treatment for these conditions: Constipation, Hepatic Encephalopathy (HE)

How Conlax Oral Solution 3.35 gm/5 ml works

Conlax Oral Solution 3.35 gm/5 ml is a synthetic disaccharide derivative of lactose that consists of one molecule of galactose and one molecule of fructose. Saccharolytic bacteria present in the large intestine subsequently break the substance down into organic acids like lactic acid and small amounts of formic and acetic acids. Such resultant volatile fatty acid metabolites, in combination with hydrogen and methane that is also generated consequently enhance intraluminal gas formation, peristaltic gut motility, and elicit an osmotic effect that facilitates an increase in the water content of stool as well as associated stool softening. All of these actions ultimately assist in facilitating and increasing the frequency of bowel movements in patients experiencing constipation, although it may take 24 to 48 hours after using the medication for this laxative effect to become evident.

At the same time, the formation of such acids via the metabolism of lactulose by colonic bacteria also acidifies the contents of the colon, thereby contributing to the treatment of portal-systemic encephalopathy (PSE). As one of the principal features of PSE involves the accumulation of nitrogenous waste products like ammonia in the systemic circulation, a state in which the colonic contents become more acidic than blood allows ammonia in the circulation to diffuse into the colon.. Furthermore, ammonia that diffuses into the acidic colon is ionized to ammonium ions that are incapable of being absorbed back into the blood. These effects, combined with the laxative action of lactulose facilitates the excretion of excess ammonia. And finally, it is also believed that an acidic colonic environment results in the elimination of urease-producing bacteria that contribute to the formation of ammonia while surviving colonic bacteria use up any trapped ammonia in the colon as a source of nitrogen for protein synthesis.

Dosage

Conlax Oral Solution 3.35 gm/5 ml dosage

Adults (including elderly): 3 tea spoonful or 15 ml twice daily

Children 5 to 10 years: 2 tea spoonful or 10 ml twice daily

Children under 5 years: 1 tea spoonful or 5 ml twice daily

Babies under 1 year: ½ tea spoonful or 2.5 ml twice daily (paediatric dose should be given after breakfast)

Each dose of Conlax Oral Solution 3.35 gm/5 mlmay, if necessary, be taken with water or fruit juices, usually once a day, preferably in the morning. If a dose is forgotten it should be taken as soon as one remembers up to 8 hours before bedtime. If later, wait for next scheduled dose (don’t double this dose). Don’t take at bedtime. Usual time lapse before drug works is 30 minutes to 3 hours.

Side Effects

Life threatening: None expected

Common: Increased thirst, cramps, nausea, diarrhoea, flatulence

Infrequent: Irregular heart beat, muscle cramps

Rare: Dizziness, confusion, fatigue, weakness.

Toxicity

It has been documented that the oral LD50 of lactulose is 48.8 mL/kg in mice and more than 30 mL/ kg in rats.

It is expected that overdosage with lactulose would result in abdominal cramps and diarrhea, both of which should be treated with fluid and electrolyte replacement as required.

Considering the use of lactulose during pregnancy in humans has not been formally investigated, the agent should only be used during pregnancy only when clearly needed. Similarly, it is unknown whether lactulose is distributed into human breastmilk. Use of the medication in nursing women should subsequently be undertaken with caution.

Reproduction studies in rats, mice, and rabbits have not revealed any evidence of impaired fertility as a result of administering lactulose.

Data regarding the safety and efficacy of using lactulose in children for the treatment of chronic constipation or portal-systemic encephalopathy (PSE) is either very limited or yet to be established.

Information regarding the long-term mutagenic potential of lactulose solution in animals or humans and about the long-term carcinogenic potential in humans are not available.

Precaution

It should be avoided if one is allergic to any hyperosmotic laxative, have symptoms of appendicitis, inflammatory bowel diseases or intestinal blockage, have missed a bowel movement for only 1 or 2 days. Adverse reactions over age 60 year may be more frequent and severe than in younger persons.

Interaction

Reduced effect with non-absorbable antacids, neomycin and other oral anti-infectives. Concomitant use with other laxatives may falsely suggest that adequate lactulose dosage has been achieved.

Food Interaction

  • Drink plenty of fluids. This drug may cause fluid loss.
  • Take with or without food.

Volume of Distribution

Negligible amounts of lactulose - metabolized or non-metabolized - are absorbed into the body.. Most lactulose that is administered subsequently remains predominantly around the gastrointestinal tract area.

Elimination Route

After administration by the oral route, less than 3% of the given dose of lactulose solution is absorbed by the small intestine. The remaining unabsorbed lactulose reaches the large intestine where it is metabolized - but even then, negligible quantities of unchanged lactulose or its metabolites are absorbed across the colon.

Half Life

The data regarding the half-life of lactulose is not readily available or accessible.

Clearance

Negligible amounts of lactulose - metabolized or non-metabolized - are absorbed into the body.. Regardless, data regarding the clearance of lactulose is not readily available or accessible.

Elimination Route

The renal excretion of any lactulose that manages to be absorbed into the circulation has been determined to be 3% or less and is generally complete within 24 hours. Any unabsorbed lactulose is largely excreted with stool.

Pregnancy & Breastfeeding use

In pregnancy no proven problems were detected. Avoid the drug if possible. Consultation with physician is required. It has no side effect during breast feeding. Conlax Oral Solution 3.35 gm/5 ml oral solution could be used in infants and children only under medical supervision. It should not be used to ‘flush out’ the system or as a ‘tonic'.

Contraindication

Conlax Oral Solution 3.35 gm/5 ml is contraindicated in patients with galactosaemia and intestinal obstruction.

Acute Overdose

There have been no reports of accidental overdosage. In the event of acute overdosage it is expected that diarrhoea and abdominal cramps would be the major symptoms.

Storage Condition

Store between 15-30° C.

FAQ

What is Conlax Oral Solution 3.35 gm/5 ml used for?

Conlax Oral Solution 3.35 gm/5 ml is a non-absorbable sugar used in the treatment of constipation and hepatic encephalopathy. Conlax Oral Solution 3.35 gm/5 ml is used by mouth for constipation and either by mouth or in the rectum for hepatic encephalopathy.Conlax Oral Solution 3.35 gm/5 ml is a laxative taken to treat constipation. It is also taken to help a severe liver disease called hepatic encephalopathy.

How safe is Conlax Oral Solution 3.35 gm/5 ml?

You should only take Conlax Oral Solution 3.35 gm/5 ml occasionally and for a few days at a time. Using laxatives like Conlax Oral Solution 3.35 gm/5 ml for longer can lead to prolonged diarrhoea. It can also cause an electrolyte imbalance, where levels of substances like sodium, potassium and magnesium in your body get too high or too low.

How does Conlax Oral Solution 3.35 gm/5 ml work?

Conlax Oral Solution 3.35 gm/5 ml is broken down in the bowel into products that pull water out from the body and into the bowel to soften poo and make it easier to pass.

What is the mechanism of action of Conlax Oral Solution 3.35 gm/5 ml?

Conlax Oral Solution 3.35 gm/5 ml is chief mechanism of action is by decreasing the intestinal production and absorption of ammonia.

What are the common side effects of Conlax Oral Solution 3.35 gm/5 ml?

The most common side effects are diarrhoea, bloating and wind. These are usually mild and shortlived.Conlax Oral Solution 3.35 gm/5 ml  takes at least 48 hours to work. If you find the taste of Conlax Oral Solution 3.35 gm/5 ml too sweet, you can dilute it with fruit juice or water.

Is Conlax Oral Solution 3.35 gm/5 ml safe during pregnancy?

Conlax Oral Solution 3.35 gm/5 ml is generally safe to take during pregnancy.

Is Conlax Oral Solution 3.35 gm/5 ml safe during breastfeeding?

Lactulose is generally safe to take during pregnancy and while breastfeeding.If you're breastfeeding, it's always better to try to safely treat constipation without taking a medicine.

Can I drink alcohol with Conlax Oral Solution 3.35 gm/5 ml?

Yes, you can drink alcohol with Conlax Oral Solution 3.35 gm/5 ml.

Is it safe to take Conlax Oral Solution 3.35 gm/5 ml every day?

Typical dosage: 2,3 tablespoons three or four times per day.Your doctor may adjust your dosage every day or every other day until you can produce two or three soft stools per day.

When shouId be taken Conlax Oral Solution 3.35 gm/5 ml ?

Conlax Oral Solution 3.35 gm/5 ml usually is taken once a day for treatment of constipation and three or four times a day for liver disease.

Can I take Conlax Oral Solution 3.35 gm/5 ml on an empty stomach?

Take lactulose once or twice a day. You can take it with or without food.

Can I take Conlax Oral Solution 3.35 gm/5 ml on an empty stomach?

Take Conlax Oral Solution 3.35 gm/5 ml once or twice a day. You can take it with or without food.

How long does Conlax Oral Solution 3.35 gm/5 ml take to work?

Conlax Oral Solution 3.35 gm/5 ml takes at least 48 hours to work.

How long does Conlax Oral Solution 3.35 gm/5 ml stay in my system?

The half-life of Conlax Oral Solution 3.35 gm/5 ml is about 2 hours while the half-life of bisacodyl is 16 hours. Bulk-forming laxatives don't have a half-life, because they're eliminated with your next bowel movement.

Can I take Conlax Oral Solution 3.35 gm/5 ml for a long time?

This will usually be for up to a week.You should only take Conlax Oral Solution 3.35 gm/5 ml occasionally and for a few days at a time.

Who should not take Conlax Oral Solution 3.35 gm/5 ml?

Use only as directed. Tell your doctor if you use other medicines or have other medical conditions or allergies.

What happens if I overdose?

Seek emergency medical attention.Overdose may cause nausea, vomiting, diarrhea, and stomach cramps, or symptoms of low blood potassium or low blood sodium (confusion, weakness, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling).

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

Does Conlax Oral Solution 3.35 gm/5 ml make me gain weight?

Ingestion of Conlax Oral Solution 3.35 gm/5 ml does not cause a weight gain because it is not digestible, with no nutritional value.

What does Conlax Oral Solution 3.35 gm/5 ml do for the liver?

Conlax Oral Solution 3.35 gm/5 ml is also used to reduce the amount of ammonia in the blood of patients with liver disease. It works by drawing ammonia from the blood into the colon where it is removed from the body.

Is Conlax Oral Solution 3.35 gm/5 ml safe for kidney patients?

Conlax Oral Solution 3.35 gm/5 ml is generally a safe medication for patients with chronic kidney disease

*** Taking medicines without doctor's advice can cause long-term problems.
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