Cool Zone D
Cool Zone D Uses, Dosage, Side Effects, Food Interaction and all others data.
Cool Zone D is dopamine receptor (D2) antagonist which selectively inhibits dopamine at the D2 receptor. It acts principally at receptors in the chemoreceptor trigger zone (CTZ) and also at receptors in the stomach.
Cool Zone D is a specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.
| Trade Name | Cool Zone D |
| Generic | Domperidone |
| Domperidone Other Names | Domperidona, Domperidone, Domperidonum |
| Type | Capsule |
| Formula | C22H24ClN5O2 |
| Weight | Average: 425.911 Monoisotopic: 425.161852744 |
| Protein binding | 91%-93% |
| Groups | Approved, Investigational, Vet approved |
| Therapeutic Class | Motility Stimulants, Motility stimulants/Dopamine antagonist, Prokinetic drugs |
| Manufacturer | Minova Life Sciences Pvt Ltd |
| Available Country | India |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Stimulation of gut motility in-
- Non-ulcer dyspepsia
- Oesophageal reflux, reflux oesophagitis and gastritis
- Diabetic gastroparesis
- Functional dyspepsia
- Speeding barium transit in follow through radiological studies
Prevention and symptomatic relief of acute nausea and vomiting from any cause including cytotoxic therapy, radiotherapy and antiparkinsonism therapy.
In the prophylactic treatment of migraine.
Cool Zone D is also used to associated treatment for these conditions: Diabetic Gastroparesis, Dyspepsia, Erosive Esophagitis, Gastrointestinal Symptoms, Non-erosive Reflux Esophagitis Disease (NERD), Upper gastrointestinal motility disorders
How Cool Zone D works
Cool Zone D acts as a gastrointestinal emptying (delayed) adjunct and peristaltic stimulant. The gastroprokinetic properties of domperidone are related to its peripheral dopamine receptor blocking properties. Cool Zone D facilitates gastric emptying and decreases small bowel transit time by increasing esophageal and gastric peristalsis and by lowering esophageal sphincter pressure. Antiemetic: The antiemetic properties of domperidone are related to its dopamine receptor blocking activity at both the chemoreceptor trigger zone and at the gastric level. It has strong affinities for the D2 and D3 dopamine receptors, which are found in the chemoreceptor trigger zone, located just outside the blood brain barrier, which - among others - regulates nausea and vomiting
Dosage
Cool Zone D dosage
Adults: 10 - 20 mg every 4 - 8 hours daily
Children: 0.2 - 0.4 mg/kg every 4 - 8 hours daily.
Cool Zone D tablet and suspension should be taken 15 - 30 minutes before a meal. For acute nausea and vomiting, maximum period of treatment is 12 weeks.
Side Effects
Cool Zone D may produce hyperprolactinemia which may cause galactorrhea & breast enlargement, soreness and reduced libido. It may rarely cause dry mouth, thirst, headache, nervousness, drowsiness, diarrhea, skin rash and itching.
Toxicity
Side effects include galactorrhea, gynecomastia, or menstrual irregularities.
Precaution
Cool Zone D should be used with absolute caution in case of children because there may be an increased risk of extra-pyramidal reactions in young children because of an incompletely developed blood brain barrier.
Interaction
Cool Zone D may reduce the hypoprolactinaemic effect of bromocriptine. Anti-muscarinics and opioid analgesics may antagonize the action of Cool Zone D on gastrointestinal function.
Food Interaction
- Take before a meal. Take 15-30 minutes before meals.
Half Life
7 hours
Pregnancy & Breastfeeding use
Use in pregnancy: The safety of this drug has not been established for pregnant women. So it is not recommended during pregnancy.
Use in lactation: Cool Zone D may precipitate galactorrhea and improve postnatal lactation, which is secreted in breast milk but in very small quantities insufficient to be considered harmful.
Contraindication
Cool Zone D is contraindicated to the patients who have hypersensitivity to this drug and in case of neonates.
Acute Overdose
Overdose has been reported primarily in infants and children. Symptoms of overdosage may include disorientation, somnolence and extrapyramidal reactions. There is no specific antidote to domperidone, but in the event of overdose, the administration of activated charcoal may be useful. Anticholinergics, antiparkinson drugs may be useful in controlling extrapyramidal reactions. The patient should be observed closely and supportive measures employed.
Storage Condition
Store in a cool dry place protected from light. Keep out of reach of children.
Innovators Monograph
You find simplified version here Cool Zone D
Cool Zone D contains Domperidone see full prescribing information from innovator Cool Zone D Monograph, Cool Zone D MSDS, Cool Zone D FDA label
FAQ
What is Cool Zone D used for?
Cool Zone D help to stop feeling or being sick like as nausea or vomiting.It can also be used to treat stomach pain if you're having end of life care. Cool Zone D is sometimes used to increase milk supply.
Is Cool Zone D safe to take?
For most people, taking Cool Zone D is safe.If you have heart problems or are taking other medicines, you should first check with your healthcare professional that this medicine is appropriate.
What are the side effects of Cool Zone D?
Common side effects of Cool Zone D are include:
- swelling of the ankles/feet.
- unusual tiredness.
- mental/mood changes (e.g., nervousness, irritability)
- hot flashes.
- breast swelling/pain.
- unusual leakage of milk from the breast.
- changes in menstrual periods.
- decreased sexual ability.
Is Cool Zone Dsafe during pregnancy?
Cool Zone D is not usually recommended in pregnancy.
Why Cool Zone D is not safe in pregnancy?
Cool Zone D is contraindicated for use in pregnant women and in women suspected of being pregnant, due to teratogenicity observed in reproductive toxicity studies.
Is Cool Zone D safe during breastfeeding?
A very small amount of the Cool Zone D you take can pass into your breast milk, but there is no record of harmful side effects in the baby from the mother taking Cool Zone D.
Can I drink alcohol with Cool Zone D?
It is best to avoid alcohol when taking Cool Zone D. Drinking alcohol can make side effects worse, such as sleepiness or an irregular heartbeat.
How long does Cool Zone D take to work?
Cool Zone D often takes at least three or four days before you notice any effect. It usually takes about two weeks to get a maximum effect, but some find it takes even longer.
Can I take Cool Zone D before bed?
Cool Zone D is best taken 15 to 30 minutes before meals and id necessary at bedtime.
Is Cool Zone D good for acid reflux?
It decreases postprandial reflux time and is therefore used to treat regurgitation and vomiting.
Can I take Cool Zone D after eating?
Cool Zone D is best taken about 15 to 30 minutes before meals, with a glass of water. If you take Cool Zone D after a meal, it will still work, but it may take longer to have an effect.
Is Cool Zone D good for gastritis?
Cool Zone D has a good advantage in the treatment of reflux gastritis and is more effective than conventional treatment.Cool Zone D is a kind of drug to strengthen gastric motility.
What does Cool Zone D do to your body?
Cool Zone D is a medicine that increases the movements or contractions of the stomach and bowel. Cool Zone D is also used to treat nausea and vomiting caused by other drugs used to treat Parkinson's Disease.
Is Cool Zone D safe for kidneys?
Cool Zone D are not significantly renally cleared and can be used in CKD.
Does Cool Zone D help anxiety?
Cool Zone D is used to treat severe anxiety like as emotional state where you may sweat, tremble, feel anxious and have a fast heartbeat or agitation.
Does Cool Zone D raise blood pressure?
Cool Zone D increases blood pressure and heart rate without inducing nocturnal hypertension in apomorphine treated patients with idiopathic Parkinson's disease.
Is Cool Zone D a narcotic?
Cool Zone D is not a controlled substance e.g. sleeping pills, valium, narcotics.
Does Cool Zone D cause depression?
Cool Zone D can cause central nervous system side effects such as fatigue, irritability, or depression.
Can I take Cool Zone D for a long time?
You should usually take Cool Zone D for up to a week.Because Cool Zone D can cause an irregular heartbeat if you take it for longer or at a high dose.
What happens when I stop taking Cool Zone D?
Most women do not experience discomfort when stopping the medication, gradual weaning from the medication will help the mother's milk supply to adjust without frustrating the baby or causing her discomfort. It is very important to stop the Cool Zone D slowly.
