Cooling 5

Cooling 5 Uses, Dosage, Side Effects, Food Interaction and all others data.

Cooling 5 is an antiseptic and disinfectant. It is active against a wide range of micro-organisms including some fungi and viruses, but is only slowly effective against spores. Cooling 5 has been used to disinfect skin and to relieve itching. Cooling 5 is also used as an oral analgesic or anesthetic in products such as Chloraseptic to treat pharyngitis. Additionally, phenol and its related compounds are used in surgical ingrown toenail treatment, a process termed phenolization. Research indicates that parental exposure to phenol and its related compounds are positively associated with spontaneous abortion. During the second world war, phenol injections were used as a means of execution by the Nazis. Cooling 5 is a toxic compound whose vapours are corrosive to the skin, eyes, and respiratory tract.

Trade Name Cooling 5
Availability Prescription only
Generic Phenol
Phenol Other Names Acide carbolique, Acide phénique, Benzenol, Carbolic acid, Carbolsäure, Fenol, Hydroxybenzene, Karbolsäure, Monohydroxybenzene, Oxybenzene, Phenic Acid, Phenol, Phenyl alcohol, Phenylic acid
Type Spray
Formula C6H6O
Weight Average: 94.1112
Monoisotopic: 94.041864814
Groups Approved, Experimental
Therapeutic Class
Manufacturer Novell Pharmaceutical
Available Country Indonesia
Last Updated: September 19, 2023 at 7:00 am
Cooling 5
Cooling 5

Uses

Cooling 5 is an antiseptic and disinfectant used in a variety of settings.

Cooling 5 is primarily indicated for minor sore throat pain, sore mouth, minor mouth irritation, and pain associated with canker sores. Additionally, phenol is indicated in the treatment of focal spasticity.

Cooling 5 is also used to associated treatment for these conditions: Dermatitis, Dermatitis, Eczematous, Irritation lips, Pruritis of the skin, Psoriasis, Ringworm, Sore Throat, Throat irritation, Moderate, stable Psoriasis

How Cooling 5 works

Cooling 5 is a potent proteolytic agent. Concentrations in the 5% to 7% range dissolve tissue on contact via proteolysis. In high concentrations when injected next to a nerve, phenol produces a chemical neurolysis which is nonselective across nerve fiber size and most prominent on its outer aspect. Local anesthetic effects occur within 5-10 minutes.

Toxicity

Mouse, Subcutaneous, LD50: 0.3-0.35 g/kg. (Duplay and Cazin, 1891; Tollens, 1905). Rat, Subcutaneous, LD50: 0.45. (Deichmann and Witherup, 1944). Rat, Oral, LD50: 0.53. (Deichmann and Witherup, 1944). Rat, Oral, LD50: 0.65. (Flickinger, 1976). Rat, Cutaneous, LD50: 0.67. (Conning and Hayes, 1970).

Food Interaction

No interactions found.

Volume of Distribution

At I5 min after exposure, the liver contained the highest level of phenol, consisting mainly of free phenol. After 82 minutes post administration, phenol is uniformly distributed in the liver, blood, kidneys, lungs, along with the heart, testes, thymus and the spleen. With the passage of time, the proportion of free to conjugated phenol changed. By 360 minutes most phenol appears in conjugated forms.

Elimination Route

Cooling 5 is rapidly absorbed through the skin and into the lungs.

Clearance

In rabbits, 72% is excreted in the urine, 1% in the feces, 4% in the carcass following sacrifice, and trace amounts were exhaled.

Elimination Route

The kidney is the primary route of elimination of phenol.

Innovators Monograph

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*** Taking medicines without doctor's advice can cause long-term problems.
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