Copalon 6%

Copalon 6% Uses, Dosage, Side Effects, Food Interaction and all others data.

Copalon 6% is an ester local anaesthetic currently available in combination with lidocaine as a cream and patch.

Trade Name Copalon 6%
Availability Prescription only
Generic Tetracaine
Tetracaine Other Names Amethocaine, Amethocaine HCl, Diäthylaminoäthanol ester der p-butylaminobenzösäure, Dicaine, Medihaler-Tetracaine, Metraspray, Tetracaína, Tétracaïne, Tetracaine, Tetracaine HCl
Type
Formula C15H24N2O2
Weight Average: 264.369
Monoisotopic: 264.183778021
Protein binding

Tetracaine is rapidly hydrolyzed in the plasma; therefore, protein binding could not be determined.

Groups Approved, Vet approved
Therapeutic Class
Manufacturer
Available Country Japan
Last Updated: September 19, 2023 at 7:00 am
Copalon 6%
Copalon 6%

Uses

Copalon 6% is a local anaesthetic agent used to induce local analgesia in the eyes and skin during medical procedures.

Ophthalmic tetracaine is indicated for the for procedures requiring a rapid and short- acting topical ophthalmic anesthetic.

The combination lidocaine and tetracaine patch is indicated for local dermal analgesia for superficial dermatological procedures and superficial venous access. The combination lidocaine and tetracaine cream is intended to provide topical local analgesia for superficial dermatological procedures.

Copalon 6% is also used to associated treatment for these conditions: Dermabrasion, Hemorrhoids, Insect Bites, Rash caused by poison ivy, Sunburn, Minor burns, Anesthetics, Local, Local Anesthesia of the Skin, Local anesthesia therapy

How Copalon 6% works

Copalon 6% is an ester-type anesthetic and produces local anesthesia by blocking the sodium ion channels involved in initiation and conduction of neuronal impulses.

Toxicity

The most common adverse effects with the combination cream are localized reactions such as: erythema (47%), skin discoloration (16%), and edema (14%). Systemic adverse events were less common, occurring at a rate of <1% and included vomiting, headache, dizziness, and fever. Similar to other amide and ester anesthetics, CNS excitation and/or depression may occur. It is not well known at which plasma concentration systemic toxicity occurs with tetracaine; however, the threshold is thought to be much lower than that of lidocaine which is 1000 ng/mL.

Food Interaction

No interactions found.

Volume of Distribution

Copalon 6% is rapidly hydrolyzed in the plasma; therefore, volume of distribution could not be determined.

Elimination Route

Systemic absorption of anaesthetic from the combination cream is directly related to the duration and surface area of application. Although peak plasma concentrations for lidocaine were measured, plasma levels for tetracaine could not be determined due to low levels (<0.9 ng/mL)

Half Life

Copalon 6% is hydrolyzed rapidly in the plasma; therefore, half-life has not been determined.

Clearance

Copalon 6% is hydrolyzed rapidly in the plasma; therefore, clearance has not been determined.

Innovators Monograph

You find simplified version here Copalon 6%

*** Taking medicines without doctor's advice can cause long-term problems.
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