Coribrom
Coribrom Uses, Dosage, Side Effects, Food Interaction and all others data.
Coribrom 0.09% is a sterile, topical, nonsteroidal anti-inflammatory drug (NSAID) for ophthalmic use. It works by blocking the effects of certain natural substances (prostaglandins) that cause pain and inflammation.
Coribrom ophthalmic solution is a sterile, topical, nonsteroidal anti-inflammatory drug (NSAID) for ophthalmic use.
| Trade Name | Coribrom |
| Availability | Discontinued |
| Generic | Bromfenac |
| Bromfenac Other Names | Bromfenac, Bromfenaco, Bromfenacum |
| Type | Eye Drops |
| Formula | C15H12BrNO3 |
| Weight | Average: 334.165 Monoisotopic: 333.000055902 |
| Groups | Approved |
| Therapeutic Class | Ophthalmic Non-Steroid drugs |
| Manufacturer | Hauz Pharma Pvt Ltd |
| Available Country | India |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
This medication is used to treat swelling (inflammation) and pain in the eye after a certain type of eye surgery (cataract surgery).
Coribrom is also used to associated treatment for these conditions: Eye Pain, Ocular Inflammation
How Coribrom works
The mechanism of its action is thought to be due to its ability to block prostaglandin synthesis by inhibiting cyclooxygenase 1 and 2. Prostaglandins have been shown in many animal models to be mediators of certain kinds of intraocular inflammation. In studies performed in animal eyes, prostaglandins have been shown to produce disruption of the blood-aqueous humor barrier, vasodilation, increased vascular permeability, leukocytosis, and increased intraocular pressure.
Dosage
Coribrom dosage
One drop should be applied to the affected eye(s) once daily beginning 1 day prior to surgery,continued on the day of surgery and through 2 weeks after surgery.
Side Effects
Abnormal sensation in eye, conjunctival hyperemia, eye irritation (including burning/stinging), eye pain, eye pruritus, eye redness, headache and iritis.
Precaution
Coribrom ophthalmic solution should be used with caution in patients with known bleeding tendencies or who are receiving other medications which may prolong bleeding time.Patients with evidence of corneal epithelial breakdown should immediately discontinue use of topical NSAIDs and should be closely monitored for corneal health.
Interaction
No information provided.
Food Interaction
No interactions found.[Moderate] ADJUST DOSE: In-vivo studies have demonstrated that the absorption of bromfenac is greatly reduced if the drug is taken within three and one-half hours following a high fat meal.
The concomitant administration of a high fat meal has led to a 75% reduction in peak plasma concentrations and a 60% reduction in total area under the curve. The mechanism has not been described.
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MANAGEMENT: An increased dosage of bromfenac (from 25 to 50 mg) may be needed if a high fat meal is consumed.
The clinician may want to warn the patient about subtherapeutic analgesic effects if high fat meals are regularly consumed.
Coribrom Hypertension interaction
[Moderate] Nonsteroidal anti-inflammatory drugs (NSAIDs), including topicals, can lead to new onset of hypertension or worsening of preexisting hypertension, either of which can contribute to the increased incidence of cardiovascular events.
NSAIDs should be used with caution in patients with hypertension.
Blood pressure should be monitored closely during the initiation of NSAID therapy and throughout the course of therapy.
Coribrom Drug Interaction
Major: lithium, lithiumUnknown: arginine, arginine, levocarnitine, levocarnitine, cysteine, cysteine, valproic acid, valproic acid, cyanocobalamin, cyanocobalamin, pyridoxine, pyridoxine, cholecalciferol, cholecalciferol, phytonadione, phytonadione, menaquinone, menaquinone
Coribrom Disease Interaction
Elimination Route
The plasma concentration of bromfenac following ocular administration in humans is unknown.
Pregnancy & Breastfeeding use
Pregnancy Category C. This drug should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.Caution should be exercised when Coribrom ophthalmic solution is administered to a nursing mother.
Contraindication
Coribrom ophthalmic solution is contraindicated in patients with known hypersensitivity to any ingredients of the formulation.
Acute Overdose
No information provided.
Storage Condition
Keep out of the reach of children.Store in a cool, dry place, away from heat and direct light. Do not use more than 4 weeks after opening.
Innovators Monograph
You find simplified version here Coribrom
Coribrom contains Bromfenac see full prescribing information from innovator Coribrom Monograph, Coribrom MSDS, Coribrom FDA label
FAQ
What is Coribrom cream used for?
Coribrom uses for:
- All dermatomycoses due to dermatophytes (e.g. Trichophyton species).
- All dermatomycoses due to yeasts (Candida species).
- Dermatomycoses due to moulds and other fungi.
- Skin diseases showing superinfections with these fungi.
To the dermatomycoses listed under 1-4 belong for example, interdigital myocoses (e.g. athlete’s foot), paronychias (associated with nail mycoses), myocoses in skin folds, Candida vulvitis, Candida balanitis, Pityriasis versicolor, erythrasma.
Do I need a prescription for Coribrom?
Coribrom topical preparations are used to treat fungus infections on the skin. This medicine is available both over-the-counter (OTC) and with your doctor's prescription. This product is available in the following dosage forms: Cream.
Is Coribrom an antibiotic?
Coribrom is an antifungal medication. It is like an antibiotic but is used to treat yeast (fungal) infections. Oral Coribrom is used to treat and prevent yeast infections of the mouth and throat. Coribrom may also be used for purposes other than those listed in this medication guide.
How to use Coribrom for yeast infection?
If you are using Coribrom cream, apply the cream to the area around the outside of your vagina and back passage two or three times daily. Rub it in gently. Continue to use the cream until the itching and soreness due to the infection are gone.
What happens if fungal infection is left untreated?
Those that penetrate into the body typically increase in severity over time and, if left untreated, may cause permanent damage and in some cases may eventually cause death. A few fungal infections may be easily passed on to other people, while others typically are not contagious.
What does a fungal infection on the skin look like?
A fungal skin infection often looks bright red and can spread across a large area. A fungal skin rash may also have characteristics including: Color more intense at the border.
Does Coribrom stop itching?
Coribrom reduces vaginal burning, itching, and discharge that may occur with this condition. This medication is an azole antifungal. It works by stopping the growth of yeast (fungus) that causes the infection.
What causes fungal infection in vagina?
The fungus candida albicans is responsible for most vaginal yeast infections. Your vagina naturally contains a balanced mix of yeast, including candida, and bacteria. Certain bacteria (lactobacillus) act to prevent an overgrowth of yeast. But that balance can be disrupted.
How effective is Coribrom?
Skin infections caused by Candida or dermatophytes have been effectively treated with topical application of Coribrom. In comparative trials, Coribrom cream has been as effective as Whitfield's ointment and tolnaftate in the treatment of dermatophytoses, and as effective as nystatin in cutaneous candidiasis.
Does Coribrom work for yeast infection?
Vaginal Coribrom is used to treat vaginal yeast infections in adults and children 12 years of age and older. Coribrom is in a class of antifungal medications called imidazoles. It works by stopping the growth of fungi that cause infection.
What are the side effects of Coribrom?
Coribrom side effects are Burning, stinging, swelling, irritation, redness, pimple-like bumps, tenderness, or flaking of the treated skin may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.
Can Coribrom kill bacteria?
It has a broad spectrum of antifungal activity. It is effective with respect to dermatophytes, and it also has an antimicrobial effect against streptococci and staphylococci. It is also effective with respect to trichomonases. It is very widely used, both externally and vaginally for treating superficial infections.
How long does it take for Coribrom cream to work?
If you are using Coribrom to treat jock itch, your symptoms should improve over 2 weeks of treatment. If you are using Coribrom to treat athlete's foot or ringworm, your symptoms should improve over 4 weeks of treatment.
Does Coribrom cream burn?
Check with your doctor as soon as possible if any of the following side effects occur while taking Coribrom topical: Skin rash, hives, blistering, burning, itching, peeling, redness, stinging, swelling, or other sign of skin irritation not present before use of this medicine.
Will Coribrom cure nail fungus?
Over-the-counter fungal creams like Coribrom don't work well for clearing nail fungus. Prescription nail polishes are available, but they take longer to work and aren't effective for severe cases.
Is Coribrom a steroid?
Coribrom is an antifungal medication that fights infections caused by fungus.
Can I use Coribrom cream on my face?
Do not use betamethasone and Coribrom cream on the face or underarms. This medicine may raise the chance of cataracts or glaucoma. Talk with the doctor.
What happens when I use Coribrom?
This medication is used to treat vaginal yeast infections. Coribrom reduces vaginal burning, itching, and discharge that may occur with this condition. This medication is an azole antifungal. It works by stopping the growth of yeast (fungus) that causes the infection.
How to apply Coribrom cream?
If you are using Coribrom cream, apply the cream to the area around the outside of your vagina and back passage two or three times daily. Rub it in gently. Continue to use the cream until the itching and soreness due to the infection are gone.
Does Coribrom stop itching?
Coribrom reduces vaginal burning, itching, and discharge that may occur with this condition. This medication is an azole antifungal. It works by stopping the growth of yeast (fungus) that causes the infection.
Is Coribrom an antibiotic?
Coribrom is an antifungal medication. It is like an antibiotic but is used to treat yeast (fungal) infections. Oral clotrimazole is used to treat and prevent yeast infections of the mouth and throat. Coribrom may also be used for purposes other than those listed in this medication guide.
What infections does Coribrom treat?
Coribrom treats different types of fungal infections including:
- athlete's foot.
- ringworm.
- fungal nail infection.
- infected nappy rash.
- rash in folds of skin (intertrigo)
- thrush.
How long does it take for Coribrom cream to work?
If you are using Coribrom to treat jock itch, your symptoms should improve over 2 weeks of treatment. If you are using Coribrom to treat athlete's foot or ringworm, your symptoms should improve over 4 weeks of treatment.
