Corphyllin

Corphyllin Uses, Dosage, Side Effects, Food Interaction and all others data.

Corphyllin is a theophylline derivative with broncho- and vasodilator properties. It is typically used in the management of asthma, cardiac dyspnea, and bronchitis.

Corphyllin, a xanthine derivative, is a bronchodilator used for relief of acute bronchial asthma and for reversible bronchospasm associated with chronic bronchitis and emphysema. Corphyllin is a xanthine derivative with pharmacologic actions similar to theophylline and other members of this class of drugs. Its primary action is that of bronchodilation, but it also exhibits peripheral vasodilatory and other smooth muscle relaxant activity to a lesser degree.

Corphyllin
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Corphyllin
Availability	Discontinued
Generic	Dyphylline
Dyphylline Other Names	Dihydroxypropyl theopylin, Diprofilina, Diprophylline, Diprophyllinum, Dyphylline
Related Drugs	Trelegy Ellipta, amoxicillin, prednisone, doxycycline, ciprofloxacin, azithromycin, ceftriaxone, levofloxacin, Symbicort, Breo Ellipta
Type
Formula	C₁₀H₁₄N₄O₄
Weight	Average: 254.2426 Monoisotopic: 254.101504956
Protein binding	84%
Groups	Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Corphyllin is a theophylline derivative used to treat asthma, bronchospasm, and COPD.

For relief of acute bronchial asthma and for reversible bronchospasm associated with chronic bronchitis and emphysema.

Corphyllin is also used to associated treatment for these conditions: Bronchial Asthma, Bronchospasm, Cheyne-Stokes Respiration

How Corphyllin works

The bronchodilatory action of dyphylline, as with other xanthines, is thought to be mediated through competitive inhibition of phosphodiesterase with a resulting increase in cyclic AMP producing relaxation of bronchial smooth muscle as well as antagonism of adenosine receptors.

Toxicity

LD₅₀=1954 mg/kg (orally in mice)

Corphyllin Hypertension interaction

[Moderate] Like other methylxanthines, dyphylline at high dosages may be associated with positive inotropic and chronotropic effects on the heart.

Therapy with dyphylline and products containing dyphylline should be administered cautiously in patients with severe cardiac disease, hypertension, hyperthyroidism, or recent myocardial infarction.

The relationship between plasma dyphylline levels and therapeutic as well as toxic effects has not been determined.

Corphyllin Drug Interaction

Minor: clonazepam, clonazepamUnknown: azelastine nasal, azelastine nasal, acetaminophen / butalbital / caffeine, acetaminophen / butalbital / caffeine, cyclobenzaprine, cyclobenzaprine, fluticasone, fluticasone, ferrous sulfate, ferrous sulfate, escitalopram, escitalopram, atropine / diphenoxylate, atropine / diphenoxylate, gabapentin, gabapentin, acetaminophen, acetaminophen

Corphyllin Disease Interaction

Major: renal dysfunction, PUDModerate: cardiotoxicity, GERD

Half Life

2 hours (range 1.8 - 2.1 hours)

Elimination Route

Corphyllin exerts its bronchodilatory effects directly and, unlike theophylline, is excreted unchanged by the kidneys without being metabolized by the liver. Approximately 88% of a single oral dose can be recovered from the urine unchanged.