Cosfen Tube

Cosfen Tube Uses, Dosage, Side Effects, Food Interaction and all others data.

Cosfen Tube is a potent broad-spectrum antimycotic agent. It exerts fungistatic and fungicidal actions on dermatophytes, pathogenic yeasts, dimorphous fungi and molds. In addition, Cosfen Tube is active against gram-positive bacteria and is therefore indicated in mycoses associated with bacterial super infections.

Cosfen Tube is also active, both in vitro and in vivo, against Trichomonas vaginalis.

Cosfen Tube exerts its unique antimycotic action through following three ways:

Inhibiting the biosynthesis of ergosterol leading to the damage of fungal cell membrane.Causing certain changes in oxidative and peroxidative enzyme activities inside fungal cell. This leads to an intracellular build-up of toxic concentrations of hydrogen peroxide resulting in cell necrosis.Inhibiting the secretion of aspartic proteases (responsible for pathogenicity) by Candidaalbicans.The amount of Cosfen Tube absorbed by the transcutaneous route is negligible.

Inhibitingthebiosynthesisofergosterolleadingtothedamageoffungalcellmembrane.Causingcertainchangesinoxidativeandperoxidativeenzymeactivitiesinsidefungalcell.Thisleadstoanintracellularbuild-upoftoxicconcentrationsofhydrogenperoxideresultingincellnecrosis.Inhibitingthesecretionofasparticproteases(responsibleforpathogenicity)byCandidaalbicans.TheamountofCosfen Tubeabsorbedbythetranscutaneousrouteisnegligible.

Cosfen Tube
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Cosfen Tube
Generic	Fenticonazole
Fenticonazole Other Names	Fenticonazole
Type	Cream
Formula	C₂₄H₂₀Cl₂N₂OS
Weight	Average: 455.4 Monoisotopic: 454.0673398
Groups	Experimental
Therapeutic Class	Topical Antifungal preparations
Manufacturer	Oaknet Healthcare Pvt Ltd
Available Country	India
Last Updated:	September 19, 2023 at 7:00 am

Uses

Cosfen Tube Nitrate is used for:

Genital candidiasis (vulvovaginitis, colpitis, infectious fuor)
Trichomonasis
Vaginal infections sustained by mixed forms of Trichomonas vaginalis and Candida albicans.

Cosfen Tube is also used to associated treatment for these conditions: Balanitis, Balanoposthitis, Candidiasis of skin NOS, Dermatomycoses, Erythrasma, Genital candidiasis, Infection caused by Malassezia infection of the scalp, Mycoses, Nail infection, Onycholysis, Otomycosis, Pityriasis versicolor, Tinea Capitis, Tinea Corporis, Tinea Cruris, Tinea Pedis, Tinea Unguium, Tinea barbae, Tinea faciei, Tinea manuum, Trichophytosis, Vaginal Candidiasis

Dosage

Cosfen Tube dosage

ginal tablet-

Vaginal infections: Cosfen Tube 600 mg vaginal tablet(followed by a second administration 24 hours later, if necessary).
Candida albicans infections: Cosfen Tube 600 mg vaginal tablet administration in the evening. Should the symptoms persist, a second administration may be repeated after three days. The vaginal tablet must be introduced deep into the vagina and pushed well up to the fornix. To avoid re-infection, it is recommended that the partner undergoes concurrent treatment with Cosfen Tube Cream or similar Azole Cream.

Cream

: Apply 2% cream once daily

Side Effects

After intravaginal administration slight transient burning (which usually disappears rapidly) may occasionally happen. Prolonged topical application may cause sensitisation reactions. Cosfen Tube is generally well tolerated by the mucous membranes; only exceptionally mild and transient erythematous reactions have been reported. After topical application or intravaginal administration, a slight burning sensation may occur, usually subsiding soon. Should more persistent irritation occur or resistant micro-organism develop, suspend the treatment and seek the doctor's advice. Due to poor absorption of Cosfen Tube, no systemic efects should occur, provided the above instructions are carefully observed.

Precaution

Discontinue if sensitization or irritation occur. Pregnancy and lactation

Pregnancy & Breastfeeding use

It is not recommended in pregnancy. Safety in breastfeeding has not been established.

Contraindication

Contraindicated in case of hypersensitivity to Cosfen Tube and other Imidazoles.

Special Warning

Cosfen Tube Nitrate is not recommended for children.

Acute Overdose

As systemic absorption is very low, the possibility of overdose is rare. In case of accidental swallowing, emesis or gastric lavage should be done. After vomiting, active charcoal along with water/lemon juice and laxative should be given to the patient.