Cositecan Uses, Dosage, Side Effects and more
Cositecan is the novel camptothecin derivative which is also known as Karenitecin. It has been developed for superior oral bioavailability and increased lactone stability. It is used to treat cancer.
| Attribute | Details |
|---|---|
| Trade Name | Cositecan |
| Generic | Cositecan |
| Cositecan Other Names | Cositecan, Karenitecin |
| Type | |
| Formula | C25H28N2O4Si |
| Weight | Average: 448.5863 Monoisotopic: 448.181833927 |
| Groups | Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | January 7, 2025 at 1:49 am |
Uses
Investigated for use/treatment in brain cancer, lung cancer, and melanoma.
How Cositecan works
BNP1350, 7-[(2-trimethylsilyl)ethyl]-20(S)-camptothecin, is a novel semi-synthetic, highly lipophilic, silicon-containing camptothecin and an inhibitor of topoisomerase I. It has been supercomputer engineered for superior oral bioavailability, superior lactone stability, broad anti-tumor activity, increased potency and insensitivity to Pgp/MRP/LRP drug resistance.
