Coughex
Coughex Uses, Dosage, Side Effects, Food Interaction and all others data.
Ammonium chloride is an inorganic compound with the formula NH4Cl. It is highly soluble in water producing mildly acidic solutions.
Systemic acidifier. In liver ammonium chloride is converted into urea with the liberation of hydrogen ions ( which lowers the pH) and chloride.
Sodium citrate is the sodium salt of citric acid. It is white, crystalline powder or white, granular crystals, slightly deliquescent in moist air, freely soluble in water,practically insoluble in alcohol. Like citric acid, it has a sour taste.From the medical point of view, it is used as alkalinizing agent. It works by neutralizing excess acid in the blood and urine. It has been indicated for the treatment of metabolic acidosis.
Citrate prevents activation of the clotting cascade by chelating calcium ions. Citrate neutralizes acid in the stomach and urine, raising the pH .
Trade Name | Coughex |
Generic | Ammonium Chloride + Chlorpheniramine / Chlorphenamine + Menthol + Sodium Citrate |
Weight | 100mg |
Type | Syrup |
Therapeutic Class | |
Manufacturer | Acme Pharmaceuticals |
Available Country | India |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
- Expectorant in cough syrups.
- The ammonium ion (NH4+) in the body plays an important role in the maintenance of acid-base balance. The kidney uses ammonium (NH4+) in place of sodium (Na+) to combine with fixed anions in maintaining acid-base balance, especially as a homeostatic compensatory mechanism in metabolic acidosis. The therapeutic effects of Ammonium Chloride depend upon the ability of the kidney to utilize ammonia in the excretion of an excess of fixed anions and the conversion of ammonia to urea by the liver, thereby liberating hydrogen (H+) and chloride (Cl–) ions into the extracellular fluid. Ammonium Chloride Injection, USP, after dilution in isotonic sodium chloride injection, may be indicated in the treatment of patients with: (1) hypochloremic states and (2) metabolic alkalosis.
Sodium citrate is an ingredient used for the anticoagulation of whole blood as part of automated apheresis procedures.
Used as an anticoagulant during plasmophoresis as well as a neutralizing agent in the treatment of upset stomach and acidic urine .
Coughex is also used to associated treatment for these conditions: Allergic Reaction, Allergic cough, Common Cold, Cough, Cough caused by Common Cold, Diabetes, High Blood Pressure (Hypertension), Metabolic Alkalosis, Nasal Congestion, Nasal Congestion Due to Allergic Rhinitis, Productive cough, Rhinorrhoea, Sneezing, Bronchial congestion, Dry cough, Excess mucus or phlegm, Hypochloremic state, Airway secretion clearance therapy, Bronchodilation, Parenteral rehydration therapy, Weight Loss, PotassiumAcidosis, Allergic cough, Allergies, Asthma, Asthma Chronic, Cough, Common Cold, Cough, Coughing caused by Bronchitis, Dehydration, Gouty Arthritis, Heartburn, Metabolic Acidosis, Phlegm, Airway secretion clearance therapy, Oral rehydration therapy, Plasmapheresis, Urine alkalinization therapy, Fluid and electrolyte maintenance therapy, Irrigation during surgical procedures, Irrigation of the ocular surface therapy
How Coughex works
Ammonium chloride increases acidity by increasing the amount of hydrogen ion concentrations.
Ammonium chloride can be used as an expectorant due to its irritative action on the bronchial mucosa. This effect causes the production of respiratory tract fluid which in order facilitates the effective cough.
Citrate chelates free calcium ions preventing them from forming a complex with tissue factor and coagulation factor VIIa to promote the activation of coagulation factor X . This inhibits the extrinsic initiation of the coagulation cascade. Citrate may also exert an anticoagulant effect via a so far unknown mechanism as restoration of calcium concentration does not fully reverse the effect of citrate . Citrate is a weak base and so reacts with hydrochloric acid in the stomach to raise the pH. It it further metabolized to bicarbonate which then acts as a systemic alkalizing agent, raising the pH of the blood and urine . It also acts as a diuretic and increases the urinary excretion of calcium.
Toxicity
LD50 "Rat" after oral administration is: 1650 mg/kg. Overdosage of Ammonium Chloride has resulted in a serious degree of metabolic acidosis, disorientation, confusion and coma. If metabolic acidosis occur following overdosage, the administration of an alkalinizing solution such as sodium bicarbonate or sodium lactate will serve to correct the acidosis.
Patients administering Ammonium chloride should be watched to the signs of ammonia toxicity including (pallor, sweating, irregular breathing, bradycardia, cardiac arrhythmias, local and general twitching, tonic convulsions and coma). It should be used with caution in patients with high total CO2 and buffer base secondary to primary respiratory acidosis. Intravenous administration should be slow to avoid local irritation and toxic effects.
Overdose toxicity is mainly due to alkalosis as well as tetany or depressed heart function due to lack of free calcium .
Volume of Distribution
Data not found.
19-39L .
Elimination Route
Completely absorbed within 3–6 h. In healthy persons, absorption of ammonium chloride given by mouth was practically complete. Only 1 to 3% of the dose was recovered in the feces.
Tmax of 98-130min .
Half Life
Unknown
18-54 min
Clearance
Data not found.
Total clearance of 313-1107mL/min .
Elimination Route
Excretion: Urine
Largely eliminated through hepatic metabolism with very little cleared by the kidneys .
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FAQ
How long Coughex tablets be used?
The dose and duration for taking Coughex will be decided by your doctor, after your diagnosis and medical tests. Do not stop taking Coughex on your own without informing your doctor.
How many Coughex should I take daily?
Coughex Dosage: One tablet or capsule daily or as advised by the physician.
How to take Coughex?
You should swallow it with a glass of water, do not break, cut, or chew the tablet. Do not consume it more than the quantity prescribed by your doctor. Take Coughex as per your doctor's advice.
What are the side effects of Coughex?
Nausea, vomiting, diarrhoea, and upset stomach may be seen as side effects. These are temporary and may disappear as your body adjusts to this supplement. If side effects persist, get in touch with your doctor.
What is the use of Coughex?
Coughex is a multi-vitamin and multi-mineral supplement. It has a combination of essential vitamins and minerals along with Zinc. It used for the treatment of vitamin and mineral deficiency and acts as an immunity booster for nursing mother.
How to take Coughex?
Coughex should be taken with food to reduce the side effects such as an upset stomach.
What is Coughex?
Coughex is a multivitamin and iron product used to treat or prevent vitamin deficiency due to poor diet, certain illnesses, or during pregnancy. Vitamins and iron are important building blocks of the body and help keep you in good health.
What are the benefits of Coughex?
Benefits of taking Coughex
- Increased energy levels
- Improved mood
- Reduces stress and anxiety
- Improved short-term memory
- Maintained muscle strength
Does Coughex increase weight?
No, but if you are having troubles with weight gain and are taking dietary supplements, then read on.
Do Coughex have side effects?
Minerals (especially taken in large doses) can cause side effects such as tooth staining, increased urination, stomach bleeding, uneven heart rate, confusion, and muscle weakness or limp feeling. When taken as directed, multivitamins and minerals are not expected to cause serious side effects.
Is Coughex good for health?
If you take a Coughex, it's probably because you want to do everything you can to protect your health. But there is still limited evidence that a daily cocktail of essential vitamins and minerals actually delivers what you expect. Most studies find no benefit from multivitamins in protecting the brain or heart.
Is Coughex good for skin?
Coughex help to keep your skin healthy and shiny by providing essential vitamins such as vitamin E and vitamin C. They help to retain your natural oil inside your skin to prevent dryness of the skin.
Do I need Coughex?
Most people do not need to take vitamin supplements and can get all the vitamins and minerals they need by eating a healthy, balanced diet. Vitamins and minerals, such as iron, calcium and vitamin C, are essential nutrients that your body needs in small amounts to work properly.
Does Coughex increase breast size?
Folic acid, an ingredient in many multivitamins, may increase breast density, which could potentially stimulate the development of cancer.
Do Coughex make my skin glow?
Vitamin C is one of the most essential vitamins you can add to your diet for glowing skin. It helps stimulate the production of collagen, which is the connective tissue that keeps your skin looking firm.