Cramid

Cramid Uses, Dosage, Side Effects, Food Interaction and all others data.

Fluorometholone is a corticosteroid with an excellent anti-inflammatory action with no significant influence on the intraocular pressure. The anti-inflammatory activity of Fluorometholone is at least 40 times stronger than that of Hydrocortisone. Corticosteroids are thought to act by the introduction of phospholipase A2 inhibitory proteins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandin and leukotrienes by inhibiting the release of their common precursor, arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2. In comparison with other corticosteroids Fluorometholone is more rapidly degraded in tissue and therefore has less effect on the intraocular pressure. The immunosuppressive action of Fluorometholone is less pronounced than that of Dexamethasone.

Corticosteroids such as fluorometholone inhibit the inflammatory response to a variety of inciting agents and probably delay or slow healing. They inhibit the edema, fibrin deposition, capillary dilation, leukocyte migration, capillary proliferation, fibroblast proliferation, deposition of collagen, and scar formation associated with inflammation.

Cramid
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Cramid
Generic	Fluorometholone + Tetrahydrozoline (HCl)
Weight	0.1%w/v, 0.25%w/v
Type	Eye Drops
Therapeutic Class
Manufacturer	Zinta Pharmaceuticals Industries
Available Country	Pakistan
Last Updated:	September 19, 2023 at 7:00 am

Uses

Fluorometholone Acetate ophthalmic suspension is used for the treatment of-

Acute and chronic non-infectious conjunctivitis and keratitis of allergic origin.
Non-infectious inflammation of the anterior chamber of the eye (including anterior uveitis, episcleritis and scleritis).
Post-operative irritative conditions after strabismus, cataract and glaucoma surgery.

Cramid is also used to associated treatment for these conditions: Anterior chamber inflammation, Conjunctivitis allergic, Corneal Inflammation, Inflammation, Ocular Inflammation, Ocular bacterial infections

How Cramid works

There is no generally accepted explanation for the mechanism of action of ocular corticosteroids. However, corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor, arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2. Their primary target is the cytosolic glucocorticoid receptor. After binding the receptor the newly formed receptor-ligand complex translocates itself into the cell nucleus, where it binds to many glucocorticoid response elements (GRE) in the promoter region of the target genes. The DNA bound receptor then interacts with basic transcription factors, causing the increase in expression of specific target genes.

Dosage

Cramid dosage

1 drop instilled into the conjunctival sac 2-4 times daily. During the initial 24 to 48 hours the dosage may be safely increased to 1 drop every hour. Care should be taken not to discontinue therapy prematurely. Shake well before use.

Side Effects

Glaucoma with optic nerve damage, visual acuity or field defects, cataract formation, secondary ocular infection following suppression of host immunity, perforation of the globe.

Toxicity

Side effects may include acute anterior uveitis and perforation of the globe. Keratitis, conjunctivitis, corneal ulcers, mydriasis, conjunctival hyperemia, loss of accommodation and ptosis have occasionally been reported following local use of corticosteroids. LD₅₀ = 234 mg/kg (rats)

Precaution

Shake well before using. If this product is used for 10 days or longer, intraocular pressure should be monitored.

Interaction

Specific drug interaction studies have not been conducted with Fluorometholone ophthalmic suspension.

Pregnancy & Breastfeeding use

Safety of the use of topical steroids during pregnancy and lactation has not been established. Fluorometholone ophthalmic suspension should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Contraindication

Hypersensitivity to any ingredient of the formulation.
Infectious conjunctivitis or keratitis.
Injuries and ulcerous processes of cornea, especially infections caused by virus, bacteria and fungi.
Dry eyes, especially keratoconjunctivitis sicca.
Glaucoma.