Crestomycin

Crestomycin Uses, Dosage, Side Effects, Food Interaction and all others data.

An oligosaccharide antibiotic produced by various streptomyces. [PubChem]

Crestomycin is a broad spectrum aminoglycoside antibiotic produced by Streptomyces rimosus var. paromomycinus. The in vitro and in vivo antibacterial action of paromomycin closely parallels that of neomycin.

Crestomycin
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
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Trade Name	Crestomycin
Availability	Prescription only
Generic	Paromomycin
Paromomycin Other Names	Aminosidin, Aminosidine, Catenulin, Crestomycin, Estomycin, Hydroxymycin, Monomycin A, Neomycin E, Paromomicina, Paromomycin, Paromomycin I, Paromomycine, Paromomycinum, Paucimycin, Paucimycinum, Zygomycin A1
Related Drugs	doxycycline, metronidazole, Flagyl, albendazole, neomycin, Vibramycin, tinidazole, nitazoxanide, praziquantel, niclosamide
Type
Formula	C₂₃H₄₅N₅O₁₄
Weight	Average: 615.6285 Monoisotopic: 615.296301173
Groups	Approved, Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Crestomycin is an aminoglycoside antibiotic used in the treatment of acute and chronic intestinal amebiasis, and as an adjunct for the management of hepatic coma.

For the treatment of acute and chronic intestinal amebiasis (it is not effective in extraintestinal amebiasis). Also for the management of hepatic coma as adjunctive therapy.

Crestomycin is also used to associated treatment for these conditions: Dientamoeba fragilis infection, Hepatic coma, Acute Intestinal amebiasis, Chronic Intestinal amebiasis

How Crestomycin works

Crestomycin inhibits protein synthesis by binding to 16S ribosomal RNA. Bacterial proteins are synthesized by ribosomal RNA complexes which are composed of 2 subunits, a large subunit (50s) and small (30s) subunit, which forms a 70s ribosomal subunit. tRNA binds to the top of this ribosomal structure. Paramomycin binds to the A site, which causes defective polypeptide chains to be produced. Continuous production of defective proteins eventually leads to bacterial death.