CSL324 Uses, Dosage, Side Effects and more

CSL324 is a fully human anti-G-CSFR antibody shown to have the ability to control G-CSF-mediated neutrophilia in cynomolgus macaques. It has potential applications in various inflammatory conditions such as cystic fibrosis, inflammatory bowel disease, rheumatoid arthritis, and vasculitis.

Trade Name CSL324
Generic CSL324
Type
Groups Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated: January 7, 2025 at 1:49 am

How CSL324 works

CSL324 binds to G-CSFR, which has been shown to neutralize the activity of G-CSF. Thus, this antibody is hypothesized to reduce G-CSF-driven mobilization and recruitment, which then, in turn, will aid in inflammation reduction. CSL324 also inhibits the G-CSF-mediated expression of CXCR1 and CXCR2 on neutrophils. Currently, it is being investigated against inflammation and COVID-19.

Innovators Monograph


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