CSL324 Uses, Dosage, Side Effects and more
CSL324 is a fully human anti-G-CSFR antibody shown to have the ability to control G-CSF-mediated neutrophilia in cynomolgus macaques. It has potential applications in various inflammatory conditions such as cystic fibrosis, inflammatory bowel disease, rheumatoid arthritis, and vasculitis.
Trade Name | CSL324 |
Generic | CSL324 |
Type | |
Groups | Investigational |
Therapeutic Class | |
Manufacturer | |
Available Country | |
Last Updated: | January 7, 2025 at 1:49 am |
How CSL324 works
CSL324 binds to G-CSFR, which has been shown to neutralize the activity of G-CSF. Thus, this antibody is hypothesized to reduce G-CSF-driven mobilization and recruitment, which then, in turn, will aid in inflammation reduction. CSL324 also inhibits the G-CSF-mediated expression of CXCR1 and CXCR2 on neutrophils. Currently, it is being investigated against inflammation and COVID-19.