Curomet S

Curomet S Uses, Dosage, Side Effects, Food Interaction and all others data.

Mometasone is a corticosteroid demonstrating anti-inflammatory properties. The precise mechanism of corticosteroids action on allergic rhinitis is not known. Corticosteroids have been shown to have a wide range of effects on multiple cell types (e.g., mast cells, eosinophils, neutrophils, macrophages, and lymphocytes) and mediators (e.g., histamine, eicosanoids, leukotrienes, and cytokines) involved in inflammation.

Mometasone is a medium-potency synthetic corticosteroid with antiinflammatory, antipruritic, and vasoconstrictive properties. Studies in asthmatic patients have demonstrated that mometasone provides a favorable ratio of topical to systemic activity due to its primary local effect along with the extensive hepatic metabolism and the lack of active metabolites. Though effective for the treatment of asthma, glucocorticoids do not affect asthma symptoms immediately. Maximum improvement in symptoms following inhaled administration of mometasone furoate may not be achieved for 1 to 2 weeks or longer after starting treatment. When glucocorticoids are discontinued, asthma stability may persist for several days or longer. Mometasone has been shown in vitro to exhibit a binding affinity for the human glucocorticoid receptor which is approximately 12 times that of dexamethasone, 7 times that of triamcinolone acetonide, 5 times that of budesonide, and 1.5 times that of fluticasone. The clinical significance of these findings is unknown.

Trade Name Curomet S
Generic Mometasone + Salisylic Acid
Weight 0.1%w/w
Type Ointment
Therapeutic Class
Manufacturer Gripil Pharmaceutical Pvt Ltd
Available Country India
Last Updated: September 19, 2023 at 7:00 am
Curomet S
Curomet S

Uses

Mometasone cream is used for the relief of inflammatory and pruritic manifestations of corticosteroid- responsive dermatoses, such as psoriasis and atopic dermatitis.

Curomet S is also used to associated treatment for these conditions: Allergic Rhinitis (AR), Asthma, Bacterial Sinusitis, Dermatitis, Pruritus, Sinusitis

How Curomet S works

Unbound corticosteroids cross cell membranes and bind with high affinity to specific cytoplasmic receptors. Inflammation is decreased by diminishing the release of leukocytic acid hydrolases, prevention of macrophage accumulation at inflamed sites, interference with leukocyte adhesion to the capillary wall, reduction of capillary membrane permeability, reduction of complement components, inhibition of histamine and kinin release, and interference with the formation of scar tissue. The antiinflammatory actions of corticosteroids are thought to involve phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes. Mometasone furoate has been shown in vitro to exhibit a binding affinity for the human glucocorticoid receptor which is approximately 12 times that of dexamethasone, 7 times that of triamcinolone acetonide, 5 times that of budesonide, and 1.5 times that of fluticasone.

Dosage

Curomet S dosage

A thin film of Mometasone Furoate cream should be applied to the affected skin areas once daily.Safety and effectiveness in paediatric patients below 2 years of age have not been established.

Side Effects

Mometasone Furoate cream is generally well tolerated. Burning, Pruritus and skin atrophy may occur.

Toxicity

The potential for acute toxic effects following overdose with the mometasone inhaler is low. However, habitual overuse of the product can cause symptoms of steroid overload, including menstrual irregularities, acne, obesity, and muscle weakness. Single oral doses up to 8000 µg have been studied on human volunteers with no adverse events reported.

Precaution

If irritation develops with the use of Mometasone Furoate cream, treatment should be discontinued.

Elimination Route

Nasal spray is virtually undetectable in plasma

Half Life

5.8 hours

Pregnancy & Breastfeeding use

Pregnancy: There is no adequate and well-controlled studies in pregnant women.

Lactation: It is not known whether this drug passes into breast milk.

Contraindication

The drug is contraindicated in individuals with a history of sensitivity reactions to Mometasone or any of the components of the preparation.

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