Cyclobenzaprine
Cyclobenzaprine Uses, Dosage, Side Effects, Food Interaction and all others data.
Nitrogen is a chemical element with symbol N and atomic number 7. At room temperature, it is a transparent, odorless diatomic gas.Liquid nitrogen is used principally in cryotherapy for removal of diseased skin. Liquid nitrogen helps in removal of skin lesions through necrosis, which results from the freezing and thawing of cells. Cryotherapy usually done in doctors' office. Also, nitrogen is very famous component in fertilizers and energy-stores.
Xylitol is a naturally occurring five-carbon sugar alcohol found in most plant material, including many fruits and vegetables. Xylitol-rich plant materials include birch and beechwood . It is widely used as a sugar substitute and in "sugar-free" food products. The effects of xylitol on dental caries have been widely studied, and xylitol is added to some chewing gums and other oral care products to prevent tooth decay and dry mouth. Xylitol is a non-fermentable sugar alcohol by most plaque bacteria, indicating that it cannot be fermented into cariogenic acid end-products . It works by inhibiting the growth of the microorganisms present in plaque and saliva after it accummulates intracellularly into the microorganism . The recommended dose of xylitol for dental caries prevention is 6–10 g/day, and most adults can tolerate 40 g/day without adverse events .
There has been evidence of xylitol in dental hygiene in reducing dental caries disease and also reversing the process of early caries . Xylitol increases salivary flow and pH, reduces the levels of Streptococcus mutans in plaque and saliva and reduces the adhesion on the microorganism to the teeth surface . Streptococcus mutans is the main target plaque microorganism , but xylitol may potentially have inhibitory actions against several other bacterial species .It prevents a shift of the bacterial community towards a more cariogenic microflora in oral environment . Oral ingestion of xylitol causes a smaller rise in plasma glucose and insulin concentrations than does the ingestion of glucose in healthy men and diabetics .
| Trade Name | Cyclobenzaprine |
| Generic | Kandungan:Larutan asam amino dengan asam amino total + nitrogen + xylitol + setiap + L-Isoleucine + L-Leucine + L-Lysine monoacetate + L-Methionine + L-Phenylalanine + L-Threonine + L-Tryptophan + L-Valine + Xylitol + Glycerine + Osmolaritas |
| Type | Capsule, extended release |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | United States |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Nitrogen is a cryogenic agent used to treat various benign and malignant skin lesions.
Liquid nitrogen is used mainly as a cryogenic agent for the treatment of various benign and malignant skin lesions.
Xylitol is an ingredient added to dental products to remove bacteria.
Indicated for use as a sugar substitute, and oral hygiene active ingredient.
Cyclobenzaprine is also used to associated treatment for these conditions: Actinic Keratosis (AK), Benign skin lesions, Hypoxemia, Warts
How Cyclobenzaprine works
In cryotherapy, mechanism of action could be classified into three stages: 1. heat transfer, 2. cell injury and 3. inflammation. Boiling point of liquid nitrogen is -196°C, which is the responsible for creating the initial stage which is heat transfer. The second stage is cell injury which is induced during thawing conditions of the cells. The last step in the cryotherapy is the inflammation stage which is characterized by edema and erythema. Inflammation occurs as a result of cellular death and it helps in local cell destruction.
Xylitol is initially taken up by the microorganism and accumulates intracellularly. Accumulated xylitol is transported into an energy-consuming cycle, or the inducible fructose transport system. It is converted to non-metabolizable, toxic xylitol-5-phosphate via phosphoenolpyruvate: a constitutive fructose phosphotransferase system by S. mutans . This metabolic process of xylitol, without the gain of any energy molecules, results in the development of intracellular vacuoles and cell membrane degradation. S. mutans dephosphorylates xylitol-5-phosphate and expels it from the cell, in which requires energy consumption. This ultimately leading to starving of microorganism and growth inhibition . Long-term exposure to xylitol can cause microorganisms to develop resistance to xylitol. This clinically beneficial selection process creates xylitol-resistant mutans strains that are less virulent and less cariogenic than their parent strains . Xylitol also increases the concentrations of ammonia and amino acids in plaque, thereby neutralizing plaque acids . A study suggests that xylitol may also promote remineralization of deeper layers of demineralized enamel by facilitating Ca2+ and phosphate movement and accessibility .
Toxicity
Liquid nitrogen: Serious adverse effects include hemorrhage, infection, and excessive granulation tissue formation. Alopecia, atrophy, keloids, scarring, hypopigmentation, and ectropion formation are among permanent complications of cryotherapy.
Oral LD50 is 16500 mg/kg in rat . At high dosages, xylitol can cause diarrhea in children at 45 g/d and 100 g/d in adults .
Volume of Distribution
For local use only.
No pharmacokinetic data available.
Elimination Route
For local use only, no systemic absorption.
Xylitol is absorbed in the small intestine via passive diffusion with a slow absorption rate .
Half Life
For local use only.
No pharmacokinetic data available.
Clearance
For local use only.
No pharmacokinetic data available.
Elimination Route
For local use only.
No pharmacokinetic data available.
Innovators Monograph
You find simplified version here Cyclobenzaprine
FAQ
What is Cyclobenzaprine?
Cyclobenzaprine is a muscle relaxant. It works by blocking nerve impulses (or pain sensations) that are sent to your brain. Cyclobenzaprine is used together with rest and physical therapy to relieve muscle spasms caused by painful conditions such as an injury.
What is Cyclobenzaprine used for?
Cyclobenzaprine oral tablet is used to help relax muscles. It helps relieve pain, stiffness, or discomfort caused by strains or injuries to your muscles. It’s used along with rest and physical therapy. It should only be used for two to three weeks at a time. Cyclobenzaprine may be used as part of a combination therapy. This means you may need to take it with other medications.
How does Cyclobenzaprine works?
It isn’t known exactly how Cyclobenzaprine works to relax your muscles. It may decrease the signals from your brain that tell your muscles to spasm.
What are the side effects of Cyclobenzaprine?
The more common side effects of Cyclobenzaprine:
- dry mouth
- dizziness
- fatigue
- constipation
- drowsiness
- nausea
- heartburn
Does Cyclobenzaprine make me sleepy?
After taking Cyclobenzaprine drowsiness, dizziness, dry mouth, constipation, or tiredness may occur.
How long does it take Cyclobenzaprine to work?
Cyclobenzaprine usually begins working about one hour after it is ingested, relaxing muscles and relieving muscle spasms. Formulations include immediate-release and extended-release.
Is Cyclobenzaprine safe to take?
You shouldn't use this drug for more than 3 weeks. Cyclobenzaprine comes with risks if you don't take it as prescribed. If you stop taking the drug suddenly or don't take it at all: Your symptoms may get worse. You may have more muscle spasms or pain.
Does Cyclobenzaprine increase blood pressure?
Cyclobenzaprine can block the blood pressure–lowering effect of guanethidine. This means your blood pressure may increase.
What class of drugs is Cyclobenzaprine?
Cyclobenzaprine is used with rest, physical therapy, and other measures to relax muscles and relieve pain and discomfort caused by strains, sprains, and other muscle injuries. Cyclobenzaprine is in a class of medications called skeletal muscle relaxants.
Does Cyclobenzaprine help with anxiety?
Cyclobenzaprine should not be used for anxiety. It can cause some of the same side effects that many anti-anxiety medications do, such as drowsiness and sleepiness. But, it is not meant to be used for this purpose.
How strong is Cyclobenzaprine?
At the standard dose of 10 mg to 30 mg a day, Cyclobenzaprine will make you sleepy. If you use it during the day, you'll want to break your 10 mg tab in half and take 5 mg to lessen the drowsiness. Interestingly, 5 mg three times a day has been shown in studies to work as well as 10 mg taken 3 times a day.
How do Cyclobenzaprine make you feel?
In general, Cyclobenzaprine act as central nervous system depressants and cause a sedative effect or prevent your nerves from sending pain signals to your brain. The onset of action is rapid and effects typically last from 4-6 hours.
Is Cyclobenzaprine tablet addictive?
Cyclobenzaprine is a commonly prescribed muscle relaxant used to treat pain and discomfort associated with muscle injuries. Although generally considered non-addictive, there is evidence that Cyclobenzaprine addiction is possible.
Is Cyclobenzaprine bad for liver?
Cyclobenzaprine is a centrally acting muscle relaxant closely related to the tricyclic antidepressants. Despite its similarity to tricyclic antidepressants, there is little evidence that Cyclobenzaprine causes liver injury.
Is Cyclobenzaprine a controlled drug?
Cyclobenzaprine is not currently controlled under the Controlled Substances Act.
Is Cyclobenzaprine safe long-term?
The manufacturer doesn't recommend use of Cyclobenzaprine beyond 2 to 3 weeks due to lack of data on efficacy with prolonged use.
What are the long-term effects of Cyclobenzaprine?
Common adverse effects that may limit or challenge long-term use of Cyclobenzaprine include somnolence, dry mouth, and dizziness.
What should not take with Cyclobenzaprine?
Avoid taking MAO inhibitors (isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine) during treatment with this medication. Most MAO inhibitors should also not be taken for two weeks before treatment with this medication.
Is Cyclobenzaprine safe to use during pregnancy?
There are no adequate studies of Cyclobenzaprine in pregnant women. However, studies in animals suggest no important effects on the fetus. Cyclobenzaprine therefore can be used in pregnancy if the physician feels that it is necessary.
Is Cyclobenzaprine safe to take while breastfeeding?
Amounts of Cyclobenzaprine in milk appear to be very small and two infants apparently tolerated the drug in milk well. If Cyclobenzaprine is required by the mother, it is not a reason to discontinue breastfeeding.
