Cyclomicin plyus

Cyclomicin plyus Uses, Dosage, Side Effects, Food Interaction and all others data.

Antibiotic substance produced by Streptomyces garyphalus.

Cycloserine, a broad-spectrum antibiotic, may be bactericidal or bacteriostatic, depending on its concentration at the site of infection and the susceptibility of the organism. Cycloserine works by blocking the formation of these peptidoglycans. By doing this the walls of the bacteria become weak and it results in the death of the bacteria

Table Of contents

• Cyclomicin plyus
• Uses
• Dosage
• Side Effect
• Precautions
• Interactions
• Uses during Pregnancy
• Uses during Breastfeeding
• Accute Overdose
• Food Interaction
• Half Life
• Volume of Distribution
• Clearance
• Interaction With other Medicine
• Contradiction
• Storage

Trade Name	Cyclomicin plyus
Generic	Cycloserine + Pyridoxine Hydrochloride
Type
Therapeutic Class
Manufacturer
Available Country	Russia
Last Updated:	September 19, 2023 at 7:00 am

Uses

Cycloserine is a broad-spectrum antibiotic used in the treatment of tuberculosis and certain urinary tract infections (UTI).

Used in combination with up to 5 other drugs as a treatment for Mycobacterium avium complex (MAC) and is also used to treat tuberculosis (TB).

Cyclomicin plyus is also used to associated treatment for these conditions: Refractory Tuberculosis, Refractory Urinary Tract Infection

How Cyclomicin plyus works

Cycloserine is an analog of the amino acid D-alanine. It interferes with an early step in bacterial cell wall synthesis in the cytoplasm by competitive inhibition of two enzymes, L-alanine racemase, which forms D-alanine from L-alanine, and D-alanylalanine synthetase, which incorporates D-alanine into the pentapeptide necessary for peptidoglycan formation and bacterial cell wall synthesis.

Toxicity

Oral LD₅₀ in mouse is 5290 mg/kg, and in rat is over 5000 mg/kg. Symptoms of a cycloserine overdose include drowsiness, confusion, headache, dizziness, irritability, numbness and tingling, difficulty speaking, paralysis, abnormal behavior, seizures, and unconsciousness.

Elimination Route

Rapidly and almost completely absorbed (70 to 90%) from the gastrointestinal tract following oral administration.

Half Life

Half-life in patients with normal renal function is 10 hours, and is prolonged in patients with impaired renal function.

Innovators Monograph

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