Cyclopentylrifampicin

Cyclopentylrifampicin Uses, Dosage, Side Effects, Food Interaction and all others data.

Cyclopentylrifampicin is an antibiotic drug used in the treatment of tuberculosis. It inhibits DNA-dependent RNA polymerase activity in susceptible cells. Specifically, it interacts with bacterial RNA polymerase but does not inhibit the mammalian enzyme.

Cyclopentylrifampicin is an antibiotic that inhibits DNA-dependent RNA polymerase activity in susceptible cells. Specifically, it interacts with bacterial RNA polymerase but does not inhibit the mammalian enzyme. It is bactericidal and has a very broad spectrum of activity against most gram-positive and gram-negative organisms (including Pseudomonas aeruginosa) and specifically Mycobacterium tuberculosis. Because of rapid emergence of resistant bacteria, use is restricted to treatment of mycobacterial infections and a few other indications. Rifampin is well absorbed when taken orally and is distributed widely in body tissues and fluids, including the CSF. It is metabolized in the liver and eliminated in bile and, to a much lesser extent, in urine, but dose adjustments are unnecessary with renal insufficiency.

Cyclopentylrifampicin
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Cyclopentylrifampicin
Availability	Prescription only
Generic	Rifapentine
Rifapentine Other Names	Cyclopentylrifampicin, Rifapentin, Rifapentine
Related Drugs	ciprofloxacin, levofloxacin, Levaquin, rifampin, isoniazid, pyrazinamide, Rifadin, Priftin, Nydrazid
Type
Formula	C₄₇H₆₄N₄O₁₂
Weight	Average: 877.0307 Monoisotopic: 876.452073532
Protein binding	97.7% (bound to plasma proteins)
Groups	Approved, Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Cyclopentylrifampicin is an antibiotic agent used in the treatment of pulmonary tuberculosis.

For the treatment of pulmonary tuberculosis.

Cyclopentylrifampicin is also used to associated treatment for these conditions: Active Tuberculosis, Late phase Tuberculosis

How Cyclopentylrifampicin works

Cyclopentylrifampicin has shown higher bacteriostatic and bactericidal activities especially against intracellular bacteria growing in human monocyte-derived macrophages. Cyclopentylrifampicin inhibits DNA-dependent RNA polymerase in susceptible strains of M. tuberculosis. Cyclopentylrifampicin acts via the inhibition of DNA-dependent RNA polymerase, leading to a suppression of RNA synthesis and cell death.

Food Interaction

Take with food. Taking rifapentine with food increases its bioavailability and reduces gastrointestinal upset. Cyclopentylrifampicin tablets can be crushed and mixed with semisolid food if necessary.

Cyclopentylrifampicin Drug Interaction

Moderate: calcium / vitamin d, codeine / guaifenesin, loratadine, medroxyprogesterone, phenytoin, atorvastatin, ergocalciferolUnknown: diphenhydramine, sucralfate, docusate, ubiquinone, carvedilol, dextromethorphan, omega-3 polyunsaturated fatty acids, alendronate, isosorbide mononitrate, propranolol, ferrous sulfate, clopidogrel, pyridoxine

Cyclopentylrifampicin Disease Interaction

Major: colitis, liver disease

Volume of Distribution

70.2 ± 9.1 L

Elimination Route

Rapidly and well absorbed from the gastrointestinal tract.

Clearance

Apparent Oral cl=2.51 +/- 0.14 L/h [Male tuberculosis patients who received 600 mg rifapentine in combination with isoniazid, pyrazinamide and ethambutol]
Apparent Oral cl=1.69 +/- 0.41 L/h [Female tuberculosis patients who received 600 mg rifapentine in combination with isoniazid, pyrazinamide and ethambutol]

Elimination Route

Following a single 600 mg oral dose of radiolabeled rifapentine to healthy volunteers (n=4), 87% of the total 14C rifapentine was recovered in the urine (17%) and feces (70%).