Cyproterone

Cyproterone Uses, Dosage, Side Effects, Food Interaction and all others data.

An anti-androgen that, in the form of its acetate (cyproterone acetate), also has progestational properties. It is used in the treatment of hypersexuality in males, as a palliative in prostatic carcinoma, and, in combination with estrogen, for the therapy of severe acne and hirsutism in females.

Cyproterone is an antiandrogen. It suppresses the actions of testosterone (and its metabolite dihydrotestosterone) on tissues. It acts by blocking androgen receptors which prevents androgens from binding to them and suppresses luteinizing hormone (which in turn reduces testosterone levels).

Table Of contents

• Cyproterone
• Uses
• Dosage
• Side Effect
• Precautions
• Interactions
• Uses during Pregnancy
• Uses during Breastfeeding
• Accute Overdose
• Food Interaction
• Half Life
• Volume of Distribution
• Clearance
• Interaction With other Medicine
• Contradiction
• Storage

Trade Name	Cyproterone
Generic	Cyproterone acetate
Cyproterone acetate Other Names	Cyproterone 17-O-acetate, Cyproterone acetate
Type
Formula	C24H29ClO4
Weight	Average: 416.938 Monoisotopic: 416.175437123
Groups	Approved, Investigational
Therapeutic Class
Manufacturer
Available Country	Canada, United States
Last Updated:	September 19, 2023 at 7:00 am

Uses

Cyproterone is a steroid used in combination with ethinyl estradiol to treat women with severe acne and symptoms of androgenization. Also used alone at much higher doses for palliative treatment of patients with prostate cancer

For the palliative treatment of patients with advanced prostatic carcinoma.

Cyproterone is also used to associated treatment for these conditions: Advanced Prostate Carcinoma, Menstrual Irregularities, Metastatic Hormone Refractory Prostate Cancer, Osteoporosis, Paraphilia, Postmenopausal Osteoporosis, Primary Amenorrhoea, Secondary Amenorrhea, Severe Acne, Hormone Replacement Therapy

How Cyproterone works

The direct antiandrogenic effect of cyproterone is blockage of the binding of dihydrotestosterone to the specific receptors in the prostatic carcinoma cell. In addition, cyproterone exerts a negative feed-back on the hypothalamo-pituitary axis, by inhibiting the secretion of luteinizing hormone resulting in diminished production of testicular testosterone.

Food Interaction

• Avoid alcohol.
• Take after a meal.

Elimination Route

Completely absorbed following oral administration.

Half Life

Elimination Following oral or intramuscular administration, the plasma half-life is 38 and 96 hours, respectively.

Elimination Route

It is excreted approximately 60% in the bile and 33% through the kidneys.

Innovators Monograph

You find simplified version here Cyproterone