D-camptothecin

D-camptothecin Uses, Dosage, Side Effects, Food Interaction and all others data.

D-camptothecin is an alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA topoisomerase, type I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity.

D-camptothecin demonstrated strong anticancer activity in preliminary clinical trials but also low solubility and adverse drug reaction. D-camptothecin is believed to be a potent topoisomerase inhibitor that interferes with the essential function of topoisomerase in DNA replication.

Table Of contents

• D-camptothecin
• Uses
• Dosage
• Side Effect
• Precautions
• Interactions
• Uses during Pregnancy
• Uses during Breastfeeding
• Accute Overdose
• Food Interaction
• Half Life
• Volume of Distribution
• Clearance
• Interaction With other Medicine
• Contradiction
• Storage

Trade Name	D-camptothecin
Generic	Camptothecin
Camptothecin Other Names	D-camptothecin
Type
Formula	C20H16N2O4
Weight	Average: 348.352 Monoisotopic: 348.11100701
Groups	Experimental
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Investigated for the treatment of cancer.

How D-camptothecin works

D-camptothecin binds to the topoisomerase I and DNA complex resulting in a ternary complex, stabilizing it and preventing DNA re-ligation and therefore causes DNA damage which results in apoptosis.

Toxicity

Acute oral toxicity (LD₅₀) in mouse: 50.1 mg/kg

Innovators Monograph

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