D-loraata
D-loraata Uses, Dosage, Side Effects, Food Interaction and all others data.
D-loraata is a long-acting, tricyclic, non-sedating, selective peripheral histamine H1-receptor antagonist which inhibits the release of pro-inflammatory mediators from human mast cells and basophils.
D-loraata is a long-acting second-generation H1-receptor antagonist which has a selective and peripheral H1-antagonist action. Histamine is a chemical that causes many of the signs that are part of allergic reactions, such as the swelling of tissues. Histamine is released from histamine-storing cells (mast cells) and attaches to other cells that have receptors for histamine. The attachment of the histamine to the receptors causes the cell to be "activated," releasing other chemicals which produce the effects that we associate with allergies. D-loraata blocks one type of receptor for histamine (the H1 receptor) and thus prevents activation of cells by histamine. Unlike most other antihistamines, D-loraata does not enter the brain from the blood and, therefore, does not cause drowsiness.
| Trade Name | D-loraata |
| Availability | Prescription only |
| Generic | Desloratadine |
| Desloratadine Other Names | Descarboethoxyloratadine, Desloratadina, Desloratadine |
| Related Drugs | prednisone, cetirizine, loratadine, fluticasone nasal, promethazine, diphenhydramine, Zyrtec, Xolair |
| Weight | 5mg |
| Type | Tablet |
| Formula | C19H19ClN2 |
| Weight | Average: 310.821 Monoisotopic: 310.123676325 |
| Protein binding | Desloratadine is bound approximately 82 to 87% to plasma proteins, while its active metabolite, 3-hydroxydesloratadine, is bound approximately 85 to 89%. |
| Groups | Approved, Investigational |
| Therapeutic Class | Non-sedating antihistamines |
| Manufacturer | Weather Folds Pharmaceuticals |
| Available Country | Pakistan |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Allergic Rhinitis: D-loraata is used for the relief of the nasal and non-nasal symptoms of allergic rhinitis (Both seasonal and perennial) in patients 2 years of age and older.
Chronic Idiopathic Urticaria: D-loraata is also used for the symptomatic relief of pruritus, reduction in the number of hives, and size of hives, in patients with chronic idiopathic urticaria 2 years of age and older.
D-loraata is also used to associated treatment for these conditions: Allergic Rhinitis (AR), Asthma, Chronic Idiopathic Urticaria, Common Cold, Nasal Congestion, Perennial Allergic Rhinitis (PAR), Seasonal Allergic Rhinitis, Nasal symptoms, Non-nasal symptoms, Antihistamine
How D-loraata works
Like other H1-blockers, D-loraata competes with free histamine for binding at H1-receptors in the GI tract, uterus, large blood vessels, and bronchial smooth muscle. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms (eg. nasal congestion, watery eyes) brought on by histamine.
Dosage
D-loraata dosage
Pediatric drops :
- Child 6 -11 months of age: 2 ml drops once daily
- Child 1 -2 years of age: 2.5 ml drops once daily
Syrup:
- Child 6-11 months of age: 2 ml once daily
- Child 1-5 years of age: 2.5 ml once daily
- Child 6-11 years of age: 5 ml once daily
- Adults & > 12 years of age: 10 ml once daily
Tablet:
- Adults and children 12 years of age and over: 5 mg daily
Side Effects
D-loraata is generally well tolerated. However, dry mouth, fatigue, somnolence and myalgia are commonly reported side-effects. Less common side-effects may include dizziness, headache and nausea. Rarely rash, pruritus and urticaria may occur.
Toxicity
Information regarding desloratadine overdose is limited, although somnolence has been reported. In case of overdose, symptomatic and supportive treatment, including removing the unabsorbed drug, is recommended; note, however, that desloratadine and its active metabolite 3-hydroxydesloratadine cannot be eliminated by hemodialysis.
In animal studies, lethality was observed at or above doses of 250 mg/kg in rats and of 353 mg/kg in mice (oral LD50), doses that represent 120 and 290 times the human exposure based on the recommended daily oral dose. In monkey, no deaths occurred at doses up to 250 mg/kg, representing an exposure roughly 810 times that of the recommended dose in humans.
Precaution
Hepatic and renal impairment. Pregnancy and lactation.
Interaction
Concomitant administration of Erythromycin, Ketoconazole, Azithromycin, Fluoxetine, and Cimetidine with D-loraata increased the plasma concentration of D-loraata. But there were no clinically relevant changes in the safety profile of D-loraata.
Food Interaction
- Take with or without food. The absorption is unaffected by food.
D-loraata Disease Interaction
Elimination Route
D-loraata administered orally for ten days to healthy volunteers as a 5 mg tablet once daily resulted in a mean Tmax of approximately 3 hours, a mean steady-state Cmax of 4 ng/ml, and a mean steady-state AUC of 56.9 ng*hr/ml. A similar profile was observed using 10 ml of an oral solution containing 5 mg of desloratadine. Food was found not to affect desloratadine absorption.
Half Life
D-loraata has a mean plasma elimination half-life of approximately 27 hours.
Elimination Route
Approximately 87% of a C-desloratadine dose was equally recovered in urine and feces as metabolic products.
Pregnancy & Breastfeeding use
Pregnancy: There are no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, D-loraata should be used in pregnancy only if clearly needed.
Lactation: D-loraata passes into breast milk. Therefore, a decision should be made whether to discontinue nursing or to discontinue D-loraata, taking into account the importance of the drug to the mother.
Contraindication
D-loraata is contraindicated in patient having hypersensitivity to this medication or to any of its ingredients or Loratadine.
Special Warning
Paediatric Use: The safety and effectiveness of D-loraata in pediatric patients under 2 years of age have not been established.
Geriatric Use: In general, dose selection for an elderly patient should be cautious, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.
In adult patients with liver or renal impairment: A starting dose of one 5 mg tablet every other day is recommended based on pharmacokinetic data.
Acute Overdose
No clinically relevant adverse events have been reported in case of overdosage. However, in the event of overdosage, symptomatic and supportive treatment is recommended.
Storage Condition
Store in a cool and dry place, protected from light.
Innovators Monograph
You find simplified version here D-loraata
D-loraata contains Desloratadine see full prescribing information from innovator D-loraata Monograph, D-loraata MSDS, D-loraata FDA label
FAQ
What is D-loraata used for?
D-loraata is an antihistamine used to relieve allergy symptoms such as watery eyes, runny nose, itching eyes/nose, sneezing, hives, and itching. D-loraata is used to treat allergies. It is an active metabolite of loratadine. It is used to relieve the symptoms of hay fever and hives of the skin.
How safe is D-loraata?
D-loraata is a safe and effective treatment for allergic diseases.
How does D-loraata work?
D-loraata works by blocking histamine, a substance in the body that causes allergic symptoms.
What are the common side effects of D-loraata?
Common side effects of D-loraata are include:
- headache.
- nausea.
- diarrhea.
- dizziness.
- sore throat.
- dry mouth.
- muscle pain.
- extreme tiredness
Is D-loraata safe during pregnancy?
As such these findings provide reassurance by indicating that the fetal safety of D-loraata is similar to the currently recommended antihistamines during pregnancy and thus D-loraata can be considered to be another option for use during pregnancy.
Is D-loraata safe during breastfeeding?
Considering the minimal exposure of a nursing infant to the drugs through breast milk, maternal use of D-loraata dose is unlikely to result in adverse effects in nursing infants and is considered to be compatible with breastfeeding.
Can I drink alcohol with D-loraata?
D-loraata alone or in combination with alcohol was safe and well tolerated.
Can I drive after taking D-loraata?
Do not drive and do not use tools or machines.
When should be taken of D-loraata?
You can take D-loraata before or after meals.
Can I take D-loraata every day?
The recommended dose of D-loraata tablets is one 5 mg tablet once daily.
How long does D-loraata take to work?
D-loraata is also use to relieve the symptoms of allergic skin conditions such as skin itch and hives. D-loraata usually starts to work within 75 minutes and lasts for 24 hours.
What is the half-life of D-loraata ?
The 27-hour half-life of D-loraata permits once daily administration.
How long can I take D-loraata for?
You can limit treatment to 14 days.
Can I take D-loraata for a long time?
D-loraata is unlikely to do you any harm if you take it for a long time. However, it's best to take it only for as long as you need to. It's best not to drink alcohol while you're taking D-loraata, as it can make you feel sleepy.
Who should not take D-loraata?
Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.
What happens if I miss a dose?
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
What happen if I overdose of D-loraata?
tiredness. sleepiness. menstrual pain. Increased sleepiness or tiredness can happen if you take more D-loraata than your doctor prescribed to you.
Can D-loraata cause infertility?
D-loraata is not expected to cause other pregnancy problems.
Does D-loraata increase blood pressure?
The decongestant in D-loraata and pseudoephedrine may cause blood pressure to increase and may also speed up the heart rate.
Can D-loraata affects my kidney?
Older patients are more likely to have kidney or liver problems which may make them more sensitive to the effects of D-loraata. Your doctor may give you a different D-loraata dose if you have kidney or liver problems.
