Daisy 1000

Daisy 1000 Uses, Dosage, Side Effects, Food Interaction and all others data.

Like all beta-lactam antibiotics, cefoperazone binds to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, causing the inhibition of the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins.

Daisy 1000 is a third generation cephalosporin antibiotic. Daisy 1000 exerts its bactericidal effect by inhibiting the bacterial cell wall synthesis

Trade Name Daisy 1000
Availability Discontinued
Generic Cefoperazone
Cefoperazone Other Names Cefoperazone, Cefoperazono, Cefoperazonum
Related Drugs amoxicillin, doxycycline, ciprofloxacin, cephalexin, metronidazole, azithromycin, clindamycin, ceftriaxone, levofloxacin, Augmentin
Weight 1g
Type Injection
Formula C25H27N9O8S2
Weight Average: 645.67
Monoisotopic: 645.142401213
Protein binding

The degree of reversible protein binding varies with the serum concentration from 93% at 25 mcg/mL to 90% at 250 mcg/mL and 82% at 500 mcg/mL. Cefotetan is 88% plasma protein bound.

Groups Approved, Investigational
Therapeutic Class Third generation Cephalosporins
Manufacturer Shaigan Pharmaceuticals (pvt) Ltd
Available Country Pakistan
Last Updated: September 19, 2023 at 7:00 am
Daisy 1000
Daisy 1000

Uses

Daisy 1000 is used for the treatment of the following infections when caused by susceptible organisms: Respiratory Tract Infections, Peritonitis & Other Intra-abdominal Infections, Bacterial Septicemia, Skin and Skin Structures Infections, Pelvic Inflammatory Disease, Endometritis & Other Infections of the Female Genital Tract, Urinary Tract Infections, Enterococcal Infections etc.

Daisy 1000 is also used to associated treatment for these conditions: Bacterial Infections, Bloodstream Infections, Bone and Joint Infections, Intra-Abdominal Infections, Lower Respiratory Tract Infection (LRTI), Meningitis, Peritonitis, Postoperative Infections, Skin and Soft Tissue Infections, Upper Respiratory Tract Infection, Urinary Tract Infection, Genital tract infection

How Daisy 1000 works

Like all beta-lactam antibiotics, cefoperazone binds to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, causing the inhibition of the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins.

Dosage

Daisy 1000 dosage

Sterile Daisy 1000 Sodium can be administered by IM or IV injection (following dilution).

Adult: 2 to 4 grams per day administered in equally divided doses every 12 hours. In severe infections or infections caused by less sensitive organisms, the total daily dose and/or frequency may be increased. Patients have been successfully treated with a total daily dosage of 6-12 grams divided into 2,3, or 4 administrations ranging from 1.5 to 4 grams per dose. When treating infections caused by Streptococcus pyogenes, therapy should be continued for at least 10 days

Daisy 1000 for intravenous or intramuscular use may be initially reconstituted with compatible solution. Solutions should be allowed to stand after reconstitution to allow any foaming to dissipate to permit visual inspection for complete solubilization. Vigorous and prolonged agitation may be necessary to solubilize Daisy 1000 in higher concentrations (above 333 mg Daisy 1000/ml). The maximum solubility of Daisy 1000 is approximately 475 mg Daisy 1000/ml of compatible diluent.

Side Effects

As with all Cephalosporins, hypersensitivity manifested by skin reactions (1 patient in 45), drug fever (1 in 260), or a change in Coombs' test (1 in 60) has been reported. These reactions are more likely to occur in patients with a history of allergies, particularly to Penicillin.

Toxicity

Symptoms of overdose include blood in the urine, diarrhea, nausea, upper abdominal pain, and vomiting.

Precaution

Daisy 1000 is extensively excreted in bile. The serum half-life of Daisy 1000 is increased 2-4 fold in patients with hepatic disease and/or biliary obstruction. In general, total daily dosage above 4 gm should not be necessary in such patients. If higher dosages are used, serum concentrations should be monitored.

Food Interaction

  • Avoid alcohol. Ingesting alcohol with cefoperazone may precipitate a disulfuram like reaction including symptoms such as flushing, tachycardia, sweating, and headache.

Daisy 1000 Alcohol interaction

[Moderate] GENERALLY AVOID:

Some cephalosporins may occasionally induce a disulfiram-like reaction when coadministered with alcohol.

The interaction has been reported for cefamandole, cefoperazone, cefotetan, and moxalactam.

These agents contain an N-methylthiotetrazole (NMTT) side chain that may inhibit aldehyde dehydrogenase (ALDH) similar to disulfiram.

Following ingestion of alcohol, inhibition of ALDH results in increased concentration of acetaldehyde, the accumulation of which produces an unpleasant physiologic response referred to as the 'disulfiram reaction'.

Symptoms include flushing, throbbing in head and neck, throbbing headache, respiratory difficulty, nausea, vomiting, sweating, thirst, chest pain, palpitation, dyspnea, hyperventilation, tachycardia, hypotension, syncope, weakness, vertigo, blurred vision, and confusion.

Severe reactions may result in respiratory depression, cardiovascular collapse, arrhythmias, myocardial infarction, acute congestive heart failure, unconsciousness, convulsions, and death.

Cefonicid contains a structurally similar side chain but did not produce elevations in blood acetaldehyde or a disulfiram reaction to ethanol in 15 healthy volunteers given single and multiple one gram doses of the drug.

Patients receiving cephalosporins with the NMTT side chain should avoid the concomitant use of alcohol and alcohol-containing products.

Daisy 1000 Hypertension interaction

[Moderate] Parenteral cefoperazone sodium contains approximately 34 mg (1.5 mEq) of sodium per each gram of cefoperazone activity.

The sodium content should be considered in patients with conditions that may require sodium restriction, such as congestive heart failure, hypertension, and fluid retention.

Half Life

The mean serum half-life is approximately 2.0 hours, independent of the route of administration.

Elimination Route

Daisy 1000 is excreted mainly in the bile.

Pregnancy & Breastfeeding use

Pregnancy Category B.This drug should be used during pregnancy only if clearly needed. Only low concentrations of Daisy 1000 is excreted in human milk. Although Daisy 1000 passes poorly into breast milk of nursing mothers, caution should be exercised when Daisy 1000 is administered to a nursing woman.

Contraindication

Daisy 1000 is contraindicated in patients with known allergy to the Cephalosporin-class of antibiotics.

Special Warning

Children use: Safety and effectiveness in children have not been established.

Geriatric use: Reported clinical experience has not identified differences in responses between the elderly and younger patients. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.

Storage Condition

Daisy 1000 is to be stored in a dry place, below 25°C and protected from light prior to reconstitution. The reconstituted solution may be stored for 24 hours if kept in room temperature (below 25°C).

Innovators Monograph

You find simplified version here Daisy 1000

Daisy 1000 contains Cefoperazone see full prescribing information from innovator Daisy 1000 Monograph, Daisy 1000 MSDS, Daisy 1000 FDA label

FAQ

What is Daisy 1000 used for?

Daisy 1000 is a cephalosporin antibiotic used to treat infections caused by bacteria.

How safe is Daisy 1000?

The clinical efficacy and safety of Daisy 1000-sulbactam were similar to those of alternative antibiotics in the treatment of intra-abdominal infections. Therefore, Daisy 1000 -sulbactam could be recommended as an effective and safe antibiotic for treating intra-abdominal infections.

How does Daisy 1000 work?

Daisy 1000 works by killing bacteria or preventing their growth. Daisy 1000 exerts its bactericidal effect by inhibiting the bacterial cell wall synthesis, and sulbactam acts as a beta-lactamase inhibitor, to increase the antibacterial activity of Daisy 1000 bagainst beta-lactamase-producing organisms.

What are the common side effects of Daisy 1000?

Common side effects of Daisy 1000 include:

  • diarrhea,
  • nausea,
  • vomiting,
  • hypersensitivity skin reactions including rash, injection site reactions (pain, swelling, or redness), or.
  • reversible low white blood cell count (neutropenia).

Is Daisy 1000 safe during pregnancy?

Daisy 1000 has been assigned to pregnancy category B by the FDA. Animal studies failed to reveal evidence of fetal harm. There are no controlled data in human pregnancy. Daisy 1000 should only be given during pregnancy when need has been clearly established.

Is Daisy 1000 safe during breastfeeding?

Daisy 1000 is acceptable in nursing mothers.

Can I drink alcohol with Daisy 1000?

Do not drink alcohol while you are taking Daisy 1000. You may have unpleasant side effects such as fast heartbeats, warmth or redness under your skin, tingly feeling, nausea, and vomiting. Check your food and medicine labels to be sure these products do not contain alcohol.

Can I drink alcohol with Daisy 1000?

Do not drink alcohol while you are taking Daisy 1000. You may have unpleasant side effects such as fast heartbeats, warmth or redness under your skin, tingly feeling, nausea, and vomiting. Check your food and medicine labels to be sure these products do not contain alcohol.

How much Daisy 1000 can I take daily?

The usual adult daily dose of Daisy 1000 is 2 to 4 grams per day.

How often can I take Daisy 1000?

Daisy 1000 administered in equally divided doses every 12 hours.

Can I take Daisy 1000 on an empty stomach?

Daisy 1000 is preferably taken with food to avoid an upset stomach.

What is the half life of Daisy 1000 sodium?

Daisy 1000 was 90% bound to serum proteins. The apparent volume of distribution was 10 to 13L. The half-life of the drug varied from 1.6 to 2.4 hours; serum clearance was between 75 and 96 ml/min.

What happen if I overdose on Daisy 1000?

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Who should not take Daisy 1000?

If you are allergic to barnd; any part of Daisy 1000; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.

What happen If I missed Daisy 1000?

Missing one or two-dose of Daisy 1000 won't show any effect on your body. The skipped dose causes no problem.

Can I just stop taking Daisy 1000?

Do not start, stop, or change the dose of any drug without checking with your doctor.

Can Daisy 1000 affect my kidneys?

Daisy 1000 promises to be an effective and safe broad-spectrum antibiotic for patients with all degrees of renal function impairment. A dosage schedule of 2 to 4 g daily will not lead to significant drug accumulation in the presence of severe renal failure.

Can Daisy 1000 affects my liver?

At usual dosages, adjustments are generally not necessary in either renal or hepatobiliary impairment.

*** Taking medicines without doctor's advice can cause long-term problems.
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