Daivonex Scalp Solution
Daivonex Scalp Solution Uses, Dosage, Side Effects, Food Interaction and all others data.
In humans, natural supply of vitamin D depends mainly on exposure to the ultraviolet rays of the sun for conversion of 7-dehydrocholesterol to vitamin D3 (cholecalciferol) in the skin. Daivonex Scalp Solution is a synthetic analog of vitamin D3. Daivonex Scalp Solution regulates skin cell production and development, thereby modifying the abnormal growth and production of keratinocytes, responsible for the plaque psoriasis.
Calcipotriene is a synthetic analog of vitamin D. In humans, the natural supply of vitamin D depends mainly on exposure to the ultraviolet rays of the sun for conversion of 7-dehydrocholesterol to vitamin D3 (cholecalciferol) in the skin.
| Trade Name | Daivonex Scalp Solution |
| Generic | Calcipotriol |
| Calcipotriol Other Names | Calcipotriene, Calcipotriol |
| Type | |
| Formula | C27H40O3 |
| Weight | Average: 412.6047 Monoisotopic: 412.297745146 |
| Groups | Approved |
| Therapeutic Class | Topical Vitamin D & related preparations |
| Manufacturer | |
| Available Country | Switzerland |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Daivonex Scalp Solution ointment is used for the treatment of plaque psoriasis in adults.
Daivonex Scalp Solution is also used to associated treatment for these conditions: Plaque psoriasis of the scalp, Psoriasis Vulgaris (Plaque Psoriasis)
How Daivonex Scalp Solution works
The precise mechanism of calcipotriol in remitting psoriasis is not well-understood, however, it has been shown to have comparable affinity with calcitriol for the Vitamin D receptor while being less than 1% the activity in regulating calcium metabolism. The Vitamin D receptor (VDR) belongs to the steroid/thyroid receptor superfamily, and is found on the cells of many different tissues including the thyroid, bone, kindney, and T cells of the immune system. T cells are known to play a role in psoriasis and are believed to undergo modulation of gene expression with binding of calcipotriol to the VDR. This modulation is thought to affect gene products related to cell differentiation and proliferation.
Dosage
Daivonex Scalp Solution dosage
A thin layer of Daivonex Scalp Solution ointment once or twice daily and rub in gently and completely. The maximum recommanded weekly dose of Daivonex Scalp Solution ointment is 100 gm/week.Pediatric use: Safety and effectiveness of Daivonex Scalp Solution ointment in pediatric patients have not been established.
Side Effects
The most frequent adverse experiences reported for Daivonex Scalp Solution ointment were cases of skin irritation, which occurred in approximately 10-15% of patients. Rash, pruritus, dermatitis and worsening of psoriasis were reported in 1 to 10% of patients. Other experiences reported in less than 1% of patients included skin atrophy, hyperpigmentation, hypercalcemia, and folliculitis.
Toxicity
Topically applied calcipotriene can be absorbed in sufficient amounts to produce systemic effects. Elevated serum calcium has been observed with excessive use of calcipotriene.
Precaution
Use of Daivonex Scalp Solution ointment may cause irritation of lesions and surrounding uninvolved skin. If irritation develops, Daivonex Scalp Solution ointment should be discontinued.Transient, rapidly reversible elevation of serum calcium has occurred with use of Daivonex Scalp Solution ointment. If elevation in serum calcium outside the normal range occurs, discontinue treatment until normal calcium levels are restored.
Food Interaction
No interactions found.Elimination Route
Clinical studies with radiolabeled ointment indicate that approximately 6% (+3%, SD) of the applied dose of calcipotriene is absorbed systemically when the ointment is applied topically to psoriasis plaques or 5% (+2.6%, SO) when applied to normal skin.
Elimination Route
The active form of the vitamin, 1,25-dihydroxy vitamin D3 (calcitriol), is known to be recycled via the liver and excreted in the bile. There is evidence that maternal 1,25-dihydroxy vitamin D3 (calcitriol) may enter the fetal circulation, but it is not known whether it is excreted in human milk.
Pregnancy & Breastfeeding use
Use in pregnancy: There are no adequate and well-controlled studies in pregnant women. Therefore, Daivonex Scalp Solution ointment should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Use in lactation: It is not known whether Daivonex Scalp Solution is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Daivonex Scalp Solution ointment is administered to a nursing woman.
Contraindication
Daivonex Scalp Solution cream & ointment is contraindicated in those patients with a history of hypersensitivity to any of the components of the preparations. It is also contraindicated in patients with known disorders of calcium metabolism.
Acute Overdose
Topically applied Daivonex Scalp Solution can be absorbed in sufficient amounts to produce systemic effects. Elevated serum calcium has been observed with excessive use of topical Daivonex Scalp Solution. If elevation in serum calcium should occur, discontinue treatment until normal calcium levels are restored.
Storage Condition
Store at 15 °C -25 °C (59 °F -77 °F). Do not freeze.
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