Damsy

Damsy Uses, Dosage, Side Effects, Food Interaction and all others data.

Mepyramine is an ethylenediamine derived antihistamine with antimuscarinic and sedating properties.

Trade Name Damsy
Generic Mepyramine + Pheniramine (Maleate) + Phenylpropanolamine (HCl)
Weight 6.25mg/5ml, 12.5mg/5ml
Type Syrup
Therapeutic Class
Manufacturer Remington Pharmaceutical Industries (pvt) Ltd,
Available Country Pakistan
Last Updated: September 19, 2023 at 7:00 am
Damsy
Damsy

Uses

Pruritic skin conditions

Damsy is also used to associated treatment for these conditions: Allergic Rhinitis (AR), Allergies, Atopic Dermatitis (AD), Common Cold, Insect Bites, Pollen Allergy, Rhinorrhoea, Urticaria, Itching skin

How Damsy works

Mepyramine is a histamine H1 receptor inverse agonist. It binds to a G protein-coupled form of the receptor and promotes a G protein-coupled inactive state of the H1 receptor that interferes with the Gq/11-mediated signaling. Mepyramine competes with histamine for binding at H1-receptor sites on the effector cell surface, resulting in suppression of histaminic edema, flare, and pruritus. The sedative properties of Mepyramine occur at the subcortical level of the CNS.

Dosage

Damsy dosage

Apply 2% cream on affected areas.

Side Effects

Sedation; antimuscarinic effects, CNS depression and disturbances; occasionally, paradoxical CNS stimulation; psychomotor impairment; headache; palpitations and arrhythmias; convulsions, sweating, myalgia, paraesthesias, extrapyramidal symptoms, tremor, sleep and Gl disturbances, hypersensitivity reactions and blood dyscrasias; hypotension; hair loss; tinnitus.

Toxicity

The signs and symptoms that are produced after the acute overdosage of Mepyramine include Convulsions, Coma, Ataxia, Hyperpyrexia, Tremor, Extrapyramidal effects, Excitement.

Precaution

Pregnancy; lactation; severe CV disorders; asthma; drowsiness; angle-closure glaucoma, urinary retention, prostatic hyperplasia, pyloroduodenal obstruction; renal and hepatic impairment; elderly; epilepsy. May affect ability to drive and operate machinery. Broken skin (topical).

Interaction

Increased effects with CNS depressants (e.g. alcohol, barbiturates, hypnotics, opioid analgesics, anxiolytic sedatives and neuroleptics). Additive effects with other antimuscarinics (e.g. TCAs, atropine).

Pregnancy & Breastfeeding use

Pregnancy Category- Not Classified. FDA has not yet classified the drug into a specified pregnancy category.

Contraindication

Severe liver disease; premature infants or full-term neonates; eczema (topical).

Innovators Monograph

You find simplified version here Damsy


*** Taking medicines without doctor's advice can cause long-term problems.
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