Дапоксетина гидрохлорид
Дапоксетина гидрохлорид Uses, Dosage, Side Effects, Food Interaction and all others data.
The mechanism of action is thought to be related to inhibition of neuronal reuptake of serotonin and subsequent potentiation of serotonin activity. The central ejaculatory neural circuit comprises spinal and cerebral areas that form a highly interconnected network. The sympathetic, parasympathetic, and somatic spinal centers, under the influence of sensory genital and cerebral stimuli integrated and processed at the spinal cord level, act in synergy to command physiologic events occurring during ejaculation. Experimental evidence indicates that serotonin (5-HT), throughout brain descending pathways, exerts an inhibitory role on ejaculation. To date, three 5-HT receptor subtypes 5-HT(1A), 5-HT(1B), and 5-HT(2C) have been postulated to mediate 5-HT's modulating activity on ejaculation.
Дапоксетина гидрохлорид is a selective serotonin reuptake inhibitor currently undergoing trials through Alza (under license from GenuPro, a collaboration between Eli Lilly and PPD). Дапоксетина гидрохлорид is a short-acting SSRI drug currently being considered for approval by the Food and Drug Administration (FDA) for the treatment of premature ejaculation in men, which would make it the first drug approved for such treatment. Despite two clinical trials finished in 2006, experts doubt it will be approved by the FDA soon because SSRIs come with undesirable side-effects after long-term use, such as psychiatric problems, dermatological reactions, increase in body weight, lower sex-drive, nausea, headache, upset stomach and weakness, thus not significantly outweighing the benefit of premature ejaculation medication versus the risks. By contrast with SSRIs approved for depression, which take 2 weeks or longer to reach steady-state concentration, dapoxetine has a unique pharmacokinetic profile, with a short time to maximum serum concentration (about 1 h) and rapid elimination (initial half-life of 1-2 h).
Trade Name | Дапоксетина гидрохлорид |
Generic | Dapoxetine |
Dapoxetine Other Names | Dapoxetina, Dapoxetine, Dapoxetinum |
Type | |
Formula | C21H23NO |
Weight | Average: 305.4134 Monoisotopic: 305.177964363 |
Groups | Investigational |
Therapeutic Class | Drugs for Erectile Dysfunction |
Manufacturer | |
Available Country | Russia |
Last Updated: | September 19, 2023 at 7:00 am |
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Uses
Indicated for the treatment of premature ejaculation (PE) in men 18 to 64 years of age, who have all of the following:
- Persistent or recurrent ejaculation with minimal sexual stimulation before, on or shortly after penetration and before the patient wishes.
- Marked personal distress or interpersonal difficulty as a consequence of PE and poor control over ejaculation.
Дапоксетина гидрохлорид is also used to associated treatment for these conditions: Premature Ejaculation
How Дапоксетина гидрохлорид works
The drug's mechanism of action is thought to be related to inhibition of neuronal reuptake of serotonin and subsequent potentiation of serotonin activity. The central ejaculatory neural circuit comprises spinal and cerebral areas that form a highly interconnected network. The sympathetic, parasympathetic, and somatic spinal centers, under the influence of sensory genital and cerebral stimuli integrated and processed at the spinal cord level, act in synergy to command physiologic events occurring during ejaculation. Experimental evidence indicates that serotonin (5-HT), throughout brain descending pathways, exerts an inhibitory role on ejaculation. To date, three 5-HT receptor subtypes (5-HT(1A), 5-HT(1B), and 5-HT(2C)) have been postulated to mediate 5-HT's modulating activity on ejaculation.
Dosage
Дапоксетина гидрохлорид dosage
Adult (18 to 64 years of age): The recommended starting dose for all patients is 30 mg, taken as needed approximately 1 to 3 hours prior to sexual activity. If the effect of 30 mg is insufficient and the side effects are acceptable, the dose may be increased to the maximum recommended dose of 60 mg. The maximum recommended dosing frequency is one dose every 24 hours.
Side Effects
Dizziness, Headache, Somnolence, Tremor, Blurred vision, Tinnitus, Sinus congestion, Nausea, Diarrhea, Abdominal pain, Dry mouth, Fatigue, Insomnia, Hypertension.
Precaution
Patient with bleeding disorders, epilepsy, susceptibility to angle-closure glaucoma or raised intraocular pressure. Not intended for use in women. Known CYP2D6 poor metabolisers.
Interaction
CNS active medicinal products: The use of Дапоксетина гидрохлорид in combination with CNS active medicinal products has not been systematically evaluated in patients with premature ejaculation. Consequently, caution is advised if the concomitant administration of Дапоксетина гидрохлорид and such medicinal products is required.
PDE5 inhibitors: Tadalafil did not affect the pharmacokinetics of Дапоксетина гидрохлорид. Sildenafil caused slight changes in Дапоксетина гидрохлорид pharmacokinetics, which are not expected to be clinically significant. However, Дапоксетина гидрохлорид should be prescribed with caution in patients who use PDE5 inhibitors due to possible reduced orthostatic tolerance.
Tamsulosin: Concomitant administration of single or multiple doses of 30 mg or 60 mg Дапоксетина гидрохлорид to patients receiving daily doses of Tamsulosin did not result in changes in the pharmacokinetics of Tamsulosin. However, Дапоксетина гидрохлорид should be prescribed with caution in patients who use alpha adrenergic receptor antagonists due to possible reduced orthostatic tolerance.
Warfarin: There are no data evaluating the effect of chronic use of Warfarin with Дапоксетина гидрохлорид; therefore, caution is advised when Дапоксетина гидрохлорид is used in patients taking Warfarin chronically.
Ethanol: Concomitant use of alcohol and Дапоксетина гидрохлорид could increase the chance or severity of adverse reactions such as dizziness, drowsiness, slow reflexes, or altered judgment. Combining alcohol with Дапоксетина гидрохлорид may increase these alcohol-related effects and may also enhance neurocardiogenic adverse events such as syncope, thereby increasing the risk of accidental injury; therefore, patients should be advised to avoid alcohol while taking Дапоксетина гидрохлорид.
Elimination Route
Rapidly absorbed.
Half Life
Initial half-life of 1-2 hours.
Pregnancy & Breastfeeding use
Дапоксетина гидрохлорид is not indicated for use by women. It is not known either dapoxetine or its metabolites are excreted through human breast milk.
Contraindication
- Patients with known hypersensitivity to Дапоксетина гидрохлорид Hydrochloride.
- Patients with significant pathological cardiac conditions such as heart failure (NYHA class II-IV), conduction abnormalities (second or third degree AV block or sick sinus syndrome) not treated with a permanent pacemaker, significant ischemic heart disease of significant valvular disease.
- Concomitant treatment with monoamine oxidase inhibitors (MAOIs), thioridazine. Similarly, MAOIs or thioridazine should not be administered within 7 days after Дапоксетина гидрохлорид has been discontinued.
- Concomitant treatment with serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs) or other medicinal/herbal products with serotonergic effects or within 14 days of discontinuing treatment with these medicinal/herbal products.
Acute Overdose
There were no unexpected adverse events in a clinical pharmacology study of Дапоксетина гидрохлорид with daily doses up to 240 mg. In general, symptoms of overdose with SSRIs include serotonin-mediated adverse reactions such as somnolence, gastrointestinal disturbances such as nausea and vomiting, tachycardia, tremor, agitation and dizziness. In cases of overdose, standard supportive measures should be adopted as required.
Storage Condition
Store below 30°C. Protect from light and moisture. Keep out of reach of children
Innovators Monograph
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Дапоксетина гидрохлорид contains Dapoxetine see full prescribing information from innovator Дапоксетина гидрохлорид Monograph, Дапоксетина гидрохлорид MSDS, Дапоксетина гидрохлорид FDA label