Daratumumab

Daratumumab Uses, Dosage, Side Effects, Food Interaction and all others data.

Daratumumab is an immunoglobulin G1 kappa monoclonal antibody developed by Janssen and Genmab. It was first described in the literature in 2010 as a monoclonal antibody that targets CD38+ multiple myeloma cells; the first of its kind.

Daratumumab was granted FDA approval on 16 November 2015.

Daratumumab is a monoclonal antibody that targets and induces apoptosis in cells that highly express CD38, including multiple myeloma cells. It has a long duration of action as it is given every 1-4 weeks. Patients should be counselled regarding the risk of hypersensitivity, neutropenia, thrombocytopenia, embryo-fetal toxicity, and interferences with cross-matching and red blood cell antibody screening.

Daratumumab
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Daratumumab
Availability	Prescription only
Generic	Daratumumab
Daratumumab Other Names	Daratumumab
Related Drugs	Darzalex, Revlimid, Velcade, Pomalyst, Ninlaro, Kyprolis
Weight	20mg/ml,
Type	Intravenous Solution, Intravenous
Formula	C₆₄₆₆H₉₉₉₆N₁₇₂₄O₂₀₁₀S₄₂
Weight	145391.67 Da
Protein binding	Data regarding protein binding of daratumumab in serum is not readily available.
Groups	Approved
Therapeutic Class
Manufacturer
Available Country	United States
Last Updated:	September 19, 2023 at 7:00 am

Uses

Daratumumab is a CD38-directed cytolytic antibody used alone or as an adjunct drug in the treatment of multiple myeloma.

Daratumumab is indicated as an intravenous injection alone or in combination with other medications for the treatment of multiple myeloma. Subcutaneous daratumumab with hyaluronidase is also indicated alone or in combination for the treatment of multiple myeloma.

Daratumumab is also used to associated treatment for these conditions: Multiple Myeloma (MM), Refractory Multiple Myeloma, Relapsed Multiple Myeloma, Relapsed Or Refractory Multiple Myeloma

How Daratumumab works

CD38 is a glycoprotein present on the surface of hematopoietic cells and is responsible for a number of cell signalling functions. Daratumumab is an immunoglobulin G1 kappa (IgG1κ) monoclonal antibody that targets CD38. Cancers like multiple myeloma overexpress CD38, allowing daratumumab to have higher affinity for these cells. This binding allows daratumumab to induce apoptosis, antibody dependent cellular phagocytosis, and antibody and complement-dependent cytotoxicity. Antibody dependent cellular phagocytosis is mediated by the FC region of the antibody inducing phagocytes such as macrophages, antibody dependent cellular cytotoxicity is mediated by the FC region of the antibody inducing effector cells such as natural killer cells, and complement dependent cytotoxicity is mediated by the FC region of the antibody binding to and inducing complement protein activity.

Toxicity

Data regarding overdoses of daratumumab are not readily available. Patients should be treated with symptomatic and supportive measures.

Food Interaction

No interactions found.

Daratumumab Drug Interaction

Unknown: aspirin, diphenhydramine, cyclophosphamide, glucose, diltiazem, apixaban, loperamide, carfilzomib, pregabalin, metoprolol, metoprolol, ixazomib, pomalidomide, lenalidomide, montelukast, acetaminophen, bortezomib, cyanocobalamin, cholecalciferol, zoledronic acid

Daratumumab Disease Interaction

Moderate: cytopenias, infusion reactions

Volume of Distribution

Daratumumab intravenous monotherapy has a volume of distribution of 4.7 ± 1.3L and the combination therapy has a volume of distribution of 4.4 ± 1.5L. Subcutaneous daratumumab has a volume of distribution of the central compartment of 5.2L and a volume of distribution of the peripheral compartment of 3.8L.

Elimination Route

Subcutaneous daratumumab reaches a C_max of 592µg/mL compared to intravenous daratumumab, which reaches a C_max of 688µg/mL. The AUC of subcutaneous daratumumab is 4017µg/mL*day compared to intravenous daratumumab, which has an AUC of 4019µg/mL*day.