Darri
Darri Uses, Dosage, Side Effects, Food Interaction and all others data.
Darri is dopamine receptor (D2) antagonist which selectively inhibits dopamine at the D2 receptor. It acts principally at receptors in the chemoreceptor trigger zone (CTZ) and also at receptors in the stomach.
Darri is a specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.
| Trade Name | Darri |
| Generic | Domperidone |
| Domperidone Other Names | Domperidona, Domperidone, Domperidonum |
| Type | Tablet, Syrup |
| Formula | C22H24ClN5O2 |
| Weight | Average: 425.911 Monoisotopic: 425.161852744 |
| Protein binding | 91%-93% |
| Groups | Approved, Investigational, Vet approved |
| Therapeutic Class | Motility Stimulants, Motility stimulants/Dopamine antagonist, Prokinetic drugs |
| Manufacturer | Aden Healthcare |
| Available Country | India |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Stimulation of gut motility in-
- Non-ulcer dyspepsia
- Oesophageal reflux, reflux oesophagitis and gastritis
- Diabetic gastroparesis
- Functional dyspepsia
- Speeding barium transit in follow through radiological studies
Prevention and symptomatic relief of acute nausea and vomiting from any cause including cytotoxic therapy, radiotherapy and antiparkinsonism therapy.
In the prophylactic treatment of migraine.
Darri is also used to associated treatment for these conditions: Diabetic Gastroparesis, Dyspepsia, Erosive Esophagitis, Gastrointestinal Symptoms, Non-erosive Reflux Esophagitis Disease (NERD), Upper gastrointestinal motility disorders
How Darri works
Darri acts as a gastrointestinal emptying (delayed) adjunct and peristaltic stimulant. The gastroprokinetic properties of domperidone are related to its peripheral dopamine receptor blocking properties. Darri facilitates gastric emptying and decreases small bowel transit time by increasing esophageal and gastric peristalsis and by lowering esophageal sphincter pressure. Antiemetic: The antiemetic properties of domperidone are related to its dopamine receptor blocking activity at both the chemoreceptor trigger zone and at the gastric level. It has strong affinities for the D2 and D3 dopamine receptors, which are found in the chemoreceptor trigger zone, located just outside the blood brain barrier, which - among others - regulates nausea and vomiting
Dosage
Darri dosage
Adults: 10 - 20 mg every 4 - 8 hours daily
Children: 0.2 - 0.4 mg/kg every 4 - 8 hours daily.
Darri tablet and suspension should be taken 15 - 30 minutes before a meal. For acute nausea and vomiting, maximum period of treatment is 12 weeks.
Side Effects
Darri may produce hyperprolactinemia which may cause galactorrhea & breast enlargement, soreness and reduced libido. It may rarely cause dry mouth, thirst, headache, nervousness, drowsiness, diarrhea, skin rash and itching.
Toxicity
Side effects include galactorrhea, gynecomastia, or menstrual irregularities.
Precaution
Darri should be used with absolute caution in case of children because there may be an increased risk of extra-pyramidal reactions in young children because of an incompletely developed blood brain barrier.
Interaction
Darri may reduce the hypoprolactinaemic effect of bromocriptine. Anti-muscarinics and opioid analgesics may antagonize the action of Darri on gastrointestinal function.
Food Interaction
- Take before a meal. Take 15-30 minutes before meals.
Half Life
7 hours
Pregnancy & Breastfeeding use
Use in pregnancy: The safety of this drug has not been established for pregnant women. So it is not recommended during pregnancy.
Use in lactation: Darri may precipitate galactorrhea and improve postnatal lactation, which is secreted in breast milk but in very small quantities insufficient to be considered harmful.
Contraindication
Darri is contraindicated to the patients who have hypersensitivity to this drug and in case of neonates.
Acute Overdose
Overdose has been reported primarily in infants and children. Symptoms of overdosage may include disorientation, somnolence and extrapyramidal reactions. There is no specific antidote to domperidone, but in the event of overdose, the administration of activated charcoal may be useful. Anticholinergics, antiparkinson drugs may be useful in controlling extrapyramidal reactions. The patient should be observed closely and supportive measures employed.
Storage Condition
Store in a cool dry place protected from light. Keep out of reach of children.
Innovators Monograph
You find simplified version here Darri
Darri contains Domperidone see full prescribing information from innovator Darri Monograph, Darri MSDS, Darri FDA label
FAQ
What is Darri used for?
Darri help to stop feeling or being sick like as nausea or vomiting.It can also be used to treat stomach pain if you're having end of life care. Darri is sometimes used to increase milk supply.
Is Darri safe to take?
For most people, taking Darri is safe.If you have heart problems or are taking other medicines, you should first check with your healthcare professional that this medicine is appropriate.
What are the side effects of Darri?
Common side effects of Darri are include:
- swelling of the ankles/feet.
- unusual tiredness.
- mental/mood changes (e.g., nervousness, irritability)
- hot flashes.
- breast swelling/pain.
- unusual leakage of milk from the breast.
- changes in menstrual periods.
- decreased sexual ability.
Is Darrisafe during pregnancy?
Darri is not usually recommended in pregnancy.
Why Darri is not safe in pregnancy?
Darri is contraindicated for use in pregnant women and in women suspected of being pregnant, due to teratogenicity observed in reproductive toxicity studies.
Is Darri safe during breastfeeding?
A very small amount of the Darri you take can pass into your breast milk, but there is no record of harmful side effects in the baby from the mother taking Darri.
Can I drink alcohol with Darri?
It is best to avoid alcohol when taking Darri. Drinking alcohol can make side effects worse, such as sleepiness or an irregular heartbeat.
How long does Darri take to work?
Darri often takes at least three or four days before you notice any effect. It usually takes about two weeks to get a maximum effect, but some find it takes even longer.
Can I take Darri before bed?
Darri is best taken 15 to 30 minutes before meals and id necessary at bedtime.
Is Darri good for acid reflux?
It decreases postprandial reflux time and is therefore used to treat regurgitation and vomiting.
Can I take Darri after eating?
Darri is best taken about 15 to 30 minutes before meals, with a glass of water. If you take Darri after a meal, it will still work, but it may take longer to have an effect.
Is Darri good for gastritis?
Darri has a good advantage in the treatment of reflux gastritis and is more effective than conventional treatment.Darri is a kind of drug to strengthen gastric motility.
What does Darri do to your body?
Darri is a medicine that increases the movements or contractions of the stomach and bowel. Darri is also used to treat nausea and vomiting caused by other drugs used to treat Parkinson's Disease.
Is Darri safe for kidneys?
Darri are not significantly renally cleared and can be used in CKD.
Does Darri help anxiety?
Darri is used to treat severe anxiety like as emotional state where you may sweat, tremble, feel anxious and have a fast heartbeat or agitation.
Does Darri raise blood pressure?
Darri increases blood pressure and heart rate without inducing nocturnal hypertension in apomorphine treated patients with idiopathic Parkinson's disease.
Is Darri a narcotic?
Darri is not a controlled substance e.g. sleeping pills, valium, narcotics.
Does Darri cause depression?
Darri can cause central nervous system side effects such as fatigue, irritability, or depression.
Can I take Darri for a long time?
You should usually take Darri for up to a week.Because Darri can cause an irregular heartbeat if you take it for longer or at a high dose.
What happens when I stop taking Darri?
Most women do not experience discomfort when stopping the medication, gradual weaning from the medication will help the mother's milk supply to adjust without frustrating the baby or causing her discomfort. It is very important to stop the Darri slowly.
