Darusentan
Darusentan Uses, Dosage, Side Effects, Food Interaction and all others data.
Darusentan is a selective endothelin ETA receptor antagonist. It is being evaluated as a treatment for congestive heart failure and hypertension.
Darusentan is a selective endothelin ETA receptor antagonist.
| Trade Name | Darusentan |
| Generic | Darusentan |
| Darusentan Other Names | Darusentan |
| Type | |
| Formula | C22H22N2O6 |
| Weight | Average: 410.4199 Monoisotopic: 410.147786446 |
| Groups | Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
For the treatment of congestive heart failure and hypertension.
How Darusentan works
The mode of action by which the endothelin receptor antagonists cause a decrease of the BP is not yet totally elucidated; however, peripheral vasodilatation due to blockade of the vasoconstrictor effects of endothelin is the most likely explanation. A reduction of cardiac contractility is considered unlikely. Several studies have been published that investigated the effects of either selective or nonselective endothelin receptor blockade in patients with heart failure. In these studies, application of endothelin antagonists, while decreasing both systemic and pulmonary BP increased cardiac index and did not alter cardiac contractility or heart rate.
Innovators Monograph
You find simplified version here Darusentan
