De-calc

De-calc Uses, Dosage, Side Effects, Food Interaction and all others data.

Calcium phosphate is typically available as an over the counter supplement, antacid, or as an added ingredient in some toothpastes .

Calcium phosphate reacts with acid in the stomach to raise the pH . In toothpaste it provides a source of calcium and phosphate ions to support remineralization of the teeth . As a supplement it provides a source of calcium and phospate, both of which are important ions in bone homeostasis.

Trade Name De-calc
Generic Calciferol + Calcium Phosphate
Weight 500iu, 325mg
Type Tablet
Therapeutic Class
Manufacturer The Schazoo Laboratories Ltd,
Available Country Pakistan
Last Updated: September 19, 2023 at 7:00 am
De-calc
De-calc

Uses

Calcium Phosphate is a compound used in supplements and antacids.

For use as an over the counter calcium and phosphate supplement, antacid, or a source of calcium and phosphate in toothpaste .

De-calc is also used to associated treatment for these conditions: Calcium Deficiency, Calcium and Vitamin D Deficiencies, Phosphate Deficiency, Dental Care

How De-calc works

The phosphate ions in calcium phosphate likely react with hydrochloric acid in the stomach to neutralize the pH. In toothpaste and in systemic circulation, calcium phosphate provides a source of calcium and phosphate ions to support remineralization of the teeth and bone homeostasis respectively. The increase in plasma calcium reduces calcium flux from osteocyte activity by reducing the secretion of parathyroid hormone (PTH) . Calcium does this by stimulating a G-protein coupled calcium receptor on the surface of parathyroid cells. The reduction in calcium flux increases the amount of calcium deposited in bone resulting in an increase in bone mineral density. The reduction in PTH secretion also reduces the amount of vitamin D metabolized to its active form, calcidiol. Since calcidiol increases the expression of calcium dependent ATPases and transient receptor potential cation channel subfamily V member 6 (TRPV6) both of which are involved in calcium uptake from the gut, a reduction in calcidiol results in less calcium absorption. Additionally, TRPV5, the channel responsible for calcium reabsorption in the kidney, is downregulated when PTH secretion is reduced thus increasing calcium excretion via the kidneys. Another hormone, calitonin, is likely involved in the reduction of bone resorption during periods of high plasma calcium.

Innovators Monograph

You find simplified version here De-calc


*** Taking medicines without doctor's advice can cause long-term problems.
Share