Decee (gep) Peadiatric

Decee (gep) Peadiatric Uses, Dosage, Side Effects, Food Interaction and all others data.

Decee (gep) Peadiatric is an anthelmintic drug that does not resemble other antiparasitic compounds. It is a synthetic organic compound which is highly specific for several parasites and does not contain any toxic metallic elements. Decee (gep) Peadiatric continues to be the mainstay for treatment of patients with lymphatic filariasis and loiasis.

The mechanism of action of diethylcarbamazine is thought to involve sensitizing the microfilariae to phagocytosis. One study showed that diethylcarbamazine's activity against Brugia malayi microfilariae is dependent on inducible nitric-oxide synthase and the cyclooxygenase pathway. It confirmed the important role of the arachidonic acid metabolic pathway in diethylcarbamazine's mechanism of action in vivo and showes that in addition to its effects on the 5-lipoxygenase pathway, it targets the cyclooxygenase pathway and COX-1.

Decee (gep) Peadiatric is an anthelmintic drug that does not resemble other antiparasitic compounds. It is a synthetic organic compound which is highly specific for several parasites and does not contain any toxic metallic elements.

Trade Name Decee (gep) Peadiatric
Generic Diethylcarbamazine
Diethylcarbamazine Other Names Diethylcarbamazin, DiƩthylcarbamazine, Diethylcarbamazine, Diethylcarbamazinum, Dietilcarbamazina
Type Syrup
Formula C10H21N3O
Weight Average: 199.2932
Monoisotopic: 199.168462309
Groups Approved, Investigational, Vet approved
Therapeutic Class Other Anti-protozoals
Manufacturer Geno Pharmaceuticals Ltd
Available Country India
Last Updated: September 19, 2023 at 7:00 am
Decee (gep) Peadiatric
Decee (gep) Peadiatric

Uses

Decee (gep) Peadiatric is used for Filariasis, Lymphatic filariasis, Pulmonary eosinophilia, Loiasis, Toxocariasis.

Decee (gep) Peadiatric is also used to associated treatment for these conditions: Filarial Infection, Onchocerciasis

How Decee (gep) Peadiatric works

The mechanism of action of diethylcarbamazine is thought to involve sensitizing the microfilariae to phagocytosis. One study showed that diethylcarbamazine's activity against Brugia malayi microfilariae is dependent on inducible nitric-oxide synthase and the cyclooxygenase pathway. It confirmed the important role of the arachidonic acid metabolic pathway in diethylcarbamazine's mechanism of action in vivo and showes that in addition to its effects on the 5-lipoxygenase pathway, it targets the cyclooxygenase pathway and COX-1.

Dosage

Decee (gep) Peadiatric dosage

Inital: 1 mg/kg/day, may increase to 6 mg/kg/day over 3 days, then maintain for 3 wk. Prophylaxis of loiasis 300 mg/wk.

Side Effects

Fever, headache, vomiting, dizziness, drowsiness, nausea, chills.

Potentially Fatal: Severe hypersensitivity reactions may occur especially in the treatment of onchocerciasis where rare Mazzotti reaction characterised by rash, itching, headache, muscle and joint pains, tachycardia, postural hypotension may start within 2 hr of drug administration. Encephalitis and retinal haemorrhage.

Toxicity

Oral LD50 in rat and mouse is 1400 mg/kg and 660 mg/kg, respectively.

Precaution

Patients with poor health.

Lactation: not known if excreted in breast milk.

Interaction

There are no known drug interactions and none well documented.

Elimination Route

Readily absorbed following oral administration.

Half Life

Approximately 8 hours.

Pregnancy & Breastfeeding use

Pregnancy Category- X. Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use of the drug in pregnant women clearly outweigh potential benefits.

Contraindication

Pregnancy, hypersensitivity; lactation; infants, elderly or debilitated patients; impaired renal function; cardiac disease.

Innovators Monograph

You find simplified version here Decee (gep) Peadiatric

Decee (gep) Peadiatric contains Diethylcarbamazine see full prescribing information from innovator Decee (gep) Peadiatric Monograph, Decee (gep) Peadiatric MSDS, Decee (gep) Peadiatric FDA label

http://classyfire.wishartlab.com/tax_nodes/C0000000
http://classyfire.wishartlab.com/tax_nodes/C0000002
http://classyfire.wishartlab.com/tax_nodes/C0002389
http://classyfire.wishartlab.com/tax_nodes/C0000189
http://classyfire.wishartlab.com/tax_nodes/C0002316
http://classyfire.wishartlab.com/tax_nodes/C0003358
http://classyfire.wishartlab.com/tax_nodes/C0000517
http://classyfire.wishartlab.com/tax_nodes/C0002239
http://classyfire.wishartlab.com/tax_nodes/C0004139
http://classyfire.wishartlab.com/tax_nodes/C0004557
http://classyfire.wishartlab.com/tax_nodes/C0003940
http://classyfire.wishartlab.com/tax_nodes/C0004150
http://classyfire.wishartlab.com/tax_nodes/C0001831
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:4527
http://www.hmdb.ca/metabolites/HMDB0014849
http://www.genome.jp/dbget-bin/www_bget?drug:D07825
http://www.genome.jp/dbget-bin/www_bget?cpd:C07968
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3052
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46506830
https://www.chemspider.com/Chemical-Structure.2944.html
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50024883
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=3384
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=4527
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL684
https://zinc.docking.org/substances/ZINC000000001288
http://bidd.nus.edu.sg/group/cjttd/ZFTTDDRUG.asp?ID=DAP000914
http://www.pharmgkb.org/drug/PA164748883
https://en.wikipedia.org/wiki/Diethylcarbamazine
*** Taking medicines without doctor's advice can cause long-term problems.
Share