Deecee Paed

Deecee Paed Uses, Dosage, Side Effects, Food Interaction and all others data.

Deecee Paed is an anthelmintic drug that does not resemble other antiparasitic compounds. It is a synthetic organic compound which is highly specific for several parasites and does not contain any toxic metallic elements. Deecee Paed continues to be the mainstay for treatment of patients with lymphatic filariasis and loiasis.

The mechanism of action of diethylcarbamazine is thought to involve sensitizing the microfilariae to phagocytosis. One study showed that diethylcarbamazine's activity against Brugia malayi microfilariae is dependent on inducible nitric-oxide synthase and the cyclooxygenase pathway. It confirmed the important role of the arachidonic acid metabolic pathway in diethylcarbamazine's mechanism of action in vivo and showes that in addition to its effects on the 5-lipoxygenase pathway, it targets the cyclooxygenase pathway and COX-1.

Deecee Paed is an anthelmintic drug that does not resemble other antiparasitic compounds. It is a synthetic organic compound which is highly specific for several parasites and does not contain any toxic metallic elements.

Trade Name Deecee Paed
Generic Diethylcarbamazine
Diethylcarbamazine Other Names Diethylcarbamazin, DiƩthylcarbamazine, Diethylcarbamazine, Diethylcarbamazinum, Dietilcarbamazina
Type Syrup
Formula C10H21N3O
Weight Average: 199.2932
Monoisotopic: 199.168462309
Groups Approved, Investigational, Vet approved
Therapeutic Class Other Anti-protozoals
Manufacturer Shrinivas Gujarat Laboratories Pvt Ltd
Available Country India
Last Updated: September 19, 2023 at 7:00 am
Deecee Paed
Deecee Paed

Uses

Deecee Paed is used for Filariasis, Lymphatic filariasis, Pulmonary eosinophilia, Loiasis, Toxocariasis.

Deecee Paed is also used to associated treatment for these conditions: Filarial Infection, Onchocerciasis

How Deecee Paed works

The mechanism of action of diethylcarbamazine is thought to involve sensitizing the microfilariae to phagocytosis. One study showed that diethylcarbamazine's activity against Brugia malayi microfilariae is dependent on inducible nitric-oxide synthase and the cyclooxygenase pathway. It confirmed the important role of the arachidonic acid metabolic pathway in diethylcarbamazine's mechanism of action in vivo and showes that in addition to its effects on the 5-lipoxygenase pathway, it targets the cyclooxygenase pathway and COX-1.

Dosage

Deecee Paed dosage

Inital: 1 mg/kg/day, may increase to 6 mg/kg/day over 3 days, then maintain for 3 wk. Prophylaxis of loiasis 300 mg/wk.

Side Effects

Fever, headache, vomiting, dizziness, drowsiness, nausea, chills.

Potentially Fatal: Severe hypersensitivity reactions may occur especially in the treatment of onchocerciasis where rare Mazzotti reaction characterised by rash, itching, headache, muscle and joint pains, tachycardia, postural hypotension may start within 2 hr of drug administration. Encephalitis and retinal haemorrhage.

Toxicity

Oral LD50 in rat and mouse is 1400 mg/kg and 660 mg/kg, respectively.

Precaution

Patients with poor health.

Lactation: not known if excreted in breast milk.

Interaction

There are no known drug interactions and none well documented.

Elimination Route

Readily absorbed following oral administration.

Half Life

Approximately 8 hours.

Pregnancy & Breastfeeding use

Pregnancy Category- X. Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use of the drug in pregnant women clearly outweigh potential benefits.

Contraindication

Pregnancy, hypersensitivity; lactation; infants, elderly or debilitated patients; impaired renal function; cardiac disease.

Innovators Monograph

You find simplified version here Deecee Paed

Deecee Paed contains Diethylcarbamazine see full prescribing information from innovator Deecee Paed Monograph, Deecee Paed MSDS, Deecee Paed FDA label

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*** Taking medicines without doctor's advice can cause long-term problems.
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