Dehydrocholic Acid
Dehydrocholic Acid Uses, Dosage, Side Effects, Food Interaction and all others data.
Dehydrocholic Acid is a synthetic bile acid that was prepared from the oxidation of cholic acid with chromic acid . It has been used for stimulation of biliary lipid secretion. The use of dehydrocholic acid in over-the-counter products has been discontinued by Health Canada.
Following infusion of dehydrocholic acid (DHCA) in rats, the secretions of all the endogenous biliary bile acids were decreased within 30-60 minutes of infusion . Phospholipid secretion as well as cholesterol levels were also declined. The bile flow was increased after administration of dehydrocholic acid .
| Trade Name | Dehydrocholic Acid |
| Generic | Dehydrocholic acid |
| Dehydrocholic acid Other Names | Decholin, Dehydrocholate, Dehydrocholic acid |
| Type | |
| Formula | C24H34O5 |
| Weight | Average: 402.531 Monoisotopic: 402.240624195 |
| Protein binding | No pharmacokinetic data available. |
| Groups | Approved, Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
No approved therapeutic indications.
Dehydrocholic Acid is also used to associated treatment for these conditions: Dyspepsia
How Dehydrocholic Acid works
It is proposed that dehydrocholic acid induces choleresis, which is associated with biliary lipid secretion and reduced secretion of endogenous and/or exogenous biliary components . Dehydrocholic Acid may decrease bile phospholipid secretion due to a lack of micelle formation by dehydrocholic acid-produced bile . A study suggests that due to enhanced permeability of tight junctions in the canalicular membranes, dehydrocholic acid facilitates direct exchange between bile and plasma .
Toxicity
Oral LD50, intravenous LD50, and intramuscular LD50 in rat is 4000 mg/kg, 750 mg/kg, and 1500 mg/kg, respectively . Oral LD50, subcutaneous LD50, and intravenous LD50 in mouse is 3100 mg/kg, 1620 mg/kg, and 1492 mg/kg, respectively . There have been no reports of overdose with dehydrocholic acid.
Food Interaction
No interactions found.Volume of Distribution
No pharmacokinetic data available.
Elimination Route
The duodenal experiment indicates that dehydrocholic acid is absorbed from the proximal small intestine .
Half Life
No pharmacokinetic data available.
Clearance
No pharmacokinetic data available.
Elimination Route
Administered dehydrocholic acid is excreted rapidly in bile as glycine- and taurine-conjugated bile acids .
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