Denileukin Diftitox

Denileukin Diftitox Uses, Dosage, Side Effects, Food Interaction and all others data.

A recombinant DNA-derived cytotoxic protein composed of the amino acid sequences for diphtheria toxin fragments A and B (Met 1-Thr 387)-His followed by the sequences for interleukin-2 (IL-2; Ala 1-Thr 133). It is produced in an E. coli expression system.

Denileukin Diftitox (Ontak) directs the cytocidal action of diphtheria toxin to cells which express the IL-2 receptor. The human IL-2 receptor exists in three forms, low (CD25), intermediate (CD122/CD132) and high (CD25/CD122/CD132) affinity. Malignant cells expressing one or more of the subunits of the IL-2 receptor are found in certain leukemias and lymphomas including cutaneous T-cell lymphoma (CTCL). Ontak interacts with the high affinity IL-2 receptor on the cell surface and inhibits cellular protein synthesis, resulting in cell death within hours.

Denileukin Diftitox
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Trade Name	Denileukin Diftitox
Generic	Denileukin diftitox
Denileukin diftitox Other Names	Denileukin, Denileukin diftitox, Interleukin-2/diptheria toxin fusion protein
Type
Formula	C₂₅₆₀H₄₀₄₂N₆₇₈O₇₉₉S₁₇
Weight	57647.3 Da
Groups	Approved, Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Denileukin Diftitox is a recombinant cytotoxic protein based on a combination of diphtheria toxin fragments and interleukin-2 used to treat cutaneous T-cell lymphoma by targeting the interleukin-2 receptor.

For treatment of cutaneous T-cell lymphoma

Denileukin Diftitox is also used to associated treatment for these conditions: Cutaneous T-Cell Lymphoma (CTCL)

How Denileukin Diftitox works

Denileukin Diftitox binds to the high-affinity IL-2 receptor complex. The IL-2 receptor (Tac) subunit is expressed on activated but not resting lymphocytes. The diphtheria toxin associated with Ontak then selectively kills the IL-2 bearing cells.