Denim
Denim Uses, Dosage, Side Effects, Food Interaction and all others data.
Denim is a nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, anti-pyretic, and analgesic properties. It inhibits prostaglandin synthetase/cyclooxygenase, which limits prostaglandin production. Its cyclooxygenase inhibiting potency is intermediate, but is relatively selective for the cyclo-oxygenase-2 (COX-2) thus the potential for gastric injury and intolerance is less. It is also a free radical scavenger, and helps protect against the tissue damage that occurs during inflammation.
Food, gender and advanced age have negligible effects on nimesulide pharmacokinetics.
| Trade Name | Denim |
| Generic | Nimesulide |
| Nimesulide Other Names | Nimesulida, Nimesulide, Nimesulidum |
| Type | Tablet |
| Formula | C13H12N2O5S |
| Weight | Average: 308.31 Monoisotopic: 308.046692194 |
| Protein binding | >97.5% |
| Groups | Approved, Investigational, Withdrawn |
| Therapeutic Class | Non-steroidal Anti-inflammatory Drugs (NSAIDs) |
| Manufacturer | Dew Drops Lab |
| Available Country | India |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Denim is used for acute pain; extra-articular disorders; osteoarthritis; post-op pain; primary dysmenorrhoea
Denim is also used to associated treatment for these conditions: Menstrual Distress (Dysmenorrhea), Pain, Pain, Acute, NSAIDs
How Denim works
The therapeutic effects of Denim are the result of its complete mode of action which targets a number of key mediators of the inflammatory process such as: COX-2 mediated prostaglandins, free radicals, proteolytic enzymes and histamine.
Dosage
Denim dosage
100 mg twice daily.Should be taken with food. Take after meals.
Side Effects
Epigastric discomfort, heartburn or abdominal cramps, nausea, vomiting and diarrhoea; skin rash, pruritus, oedema, headache, dizziness, drowsiness; hypersensitivity reactions (e.g. bronchospasm, rhinitis, angioedema urticaria); GI haemorrhage/perforation; bullous/erosive stomatitis, purpura, thrombocytopenia, toxic epidermal necrolysis, haematuria, oliguria, and renal failure; increases in liver enzymes.
Toxicity
Oral TDLO (human): 1.429 mg/kg; Oral TDLO (woman): 2 mg/kg; Oral LD50 (rat): 200 mg/kg; Oral LD50 (mouse): 392 mg/kg
Precaution
History of GI tract disease, infections, oedema, hypertension, elderly, lactation.
Interaction
Additive hepatotoxic effects with known hepatotoxins: anti-convulsants (e.g. valproic acid), anti-fungals (e.g. ketoconazole), anti-tuberculous drugs (e.g. isoniazid), tacrine, pemoline, amiodarone, methotrexate, methyldopa, amoxicillin/clavulanic acid. May decrease the oral bioavailability of furosemide and the natriuretic and diuretic response to furosemide. Increased risks of GI and hepatic adverse effects with other NSAIDs, including aspirin. May increase anti-coagulant effect of warfarin. Potentiates the action of phenytoin. May be displaced from binding sites with fenofibrate, salicylic acid, and tolbutamide. Interactions between NSAIDs and lithium, probenecid and ciclosporin, have been documented.
Elimination Route
Rapidly absorbed following oral administration.
Half Life
1.8–4.7 hours
Elimination Route
Renal (50%), fecal (29%)
Pregnancy & Breastfeeding use
Category not classified
Contraindication
Hypersensitivity; GI bleeding, active peptic ulcer disease; severe renal and heart failure; hepatic impairment or known liver disease; coagulation disorders; pregnancy; children <12 yr.
Acute Overdose
Epigastric pain, nausea, vomiting, drowsiness, lethargy, GI haemorrhage, seizures, hypertension, apnoea, coma, anaphylactic reactions and renal failure. Treatment is supportive.
Storage Condition
Protect from heat and humidity; store at <25°C.
Innovators Monograph
You find simplified version here Denim
FAQ
What is Denim used for?
Denim is a medication used for pain relief and for the prevention of fever. Acute pain, pain due to menstrual cramps, backache, post-operative pain, osteoarthritis and fever are frequently prescribed.
how safe Denim is?
It is safer to use one with a favourable benefit-harm balance, such as ibuprofen, when a non-steroidal anti-inflammatory drug is required.The drug is best avoided in known or suspected liver disease; caution is warranted while prescribing nimesulide concomitantly with other hepatotoxic drugs.
What are the common side effect of Denim ?
Denim is generally well tolerated, but side effects can include headache, dizziness, somnolence, gastrointestinal upset, nausea, abdominal discomfort, diarrhea, peripheral edema and hypersensitivity reactions.
Is Denim bad for liver?
Denim must be withdrawn worldwide due to serious liver damage.Denim exposes patients to fatal liver damage.
How quickly does Denim work?
Denim works rapidly with immediate onset of action when taken orally. It can effectively reduce pain or fever within 15minutes of taking the medicine.
Is Denim safe during pregnancy?
Our study suggests that the use of Denim in early pregnancy may result in a greater risk of having births with congenital urinary tract anomalies.
Can I take Denim while breastfeeding?
The action of Denim on milk production for infants or the composition of milk is currently unknown. Some studies also suggest that Denim is unsafe for lactating women., lactating women are advised to take medical expert advice, take this drug with precautions, and avoid long-term use.
Can I take Denim safe with alcohol?
Avoid consuming alcohol while taking Denim as it can increase your risk of stomach problems.
Does bnrand increase blood pressure?
Our results indicate no difference between Denim and ketoprofen effects on mean blood pressure values during antihypertensive therapy.
Can Denim be taken empty stomach?
Do not take it on an empty stomach.Always take Denim together with food or immediately after a meal.
Is Denim safe for kidneys?
This observation indicates that Denim can provoke acute renal failure as a result of an obstructive crystalline nephropathy.
Can heart patients take Denim?
Denim should be used with great caution in patients with compromised renal function, cirrhosis of liver, congestive heart failure, renovascular disease, volume or salt depletion.
Is Denim good for headache?
Denim with Paracetamol is used for pain relief.
Is Denim used for migraine?
Denim has a well documented efficacy for relieving symptoms associated with migraine and non-migraine headaches.
Can Denim I take in periods?
Denim reduces the pressure during the maximal but not during the submaximal pain period, with concomitant alleviation of pain. The drug changes the painful state of uterine contracture to painless cyclic contractions.
Can Denim use for ear pain?
Denim indicate that the drug may be an effective and well tolerated therapy for painful inflammatory conditions of the ear, nose and throat.
Can Denim cause sleepiness?
Denim suspension overdose can make you drowsy (feeling sleepy).Generally suspension does not make you feel drowsy.
Can Denim be used for throat pain?
Denim which may be prescribed by your doctor to get rid of a sore throat and fever if you get these symptoms.
Is Denim safe for adults?
Denim may safe for adult if Denim recommended dose in 100 mg twice daily for no more than 15 days.
How bad is bnand?
Denim must be withdrawn worldwide due to serious liver damage.It exposes patients to fatal liver damage.
Can I take Denim for a long time?
Denim is not recommended long-term, as for chronic conditions such as arthritis. This is due to its association with an increased risk of liver toxicity, including liver failure.
Can I drive after taking Denim?
Denim may cause dizziness. If you feel dizzy, do not drive or take part in any activity in which you need to be alert.
