Denivert W
Denivert W Uses, Dosage, Side Effects, Food Interaction and all others data.
Denivert W is obtained from sugar cane when this is treated with dilute acid or with the invertase enzyme. It is formed by an equal amount of glucose and fructose. It differentiates from sugar cane in the rotation of the polarized light, which in the case of invert sugar it is to the left (levorotatory). Denivert W is FDA approved since 1988 as a safe substance (GRAS).
Intravenous administration of invert sugar has been proven to be favorable. These reports indicate a temporary rise, within physiological levels, of lactate, pyruvate, and insulin in the blood plasma whereas the level of free fatty acids was declined.
| Trade Name | Denivert W |
| Generic | Invert sugar |
| Type | Infusion |
| Groups | Experimental |
| Therapeutic Class | |
| Manufacturer | Claris Lifesciences Limited |
| Available Country | India |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Denivert W presents a large variety of uses. It can be used therapeutically for parenteral hyperalimentation or to be used as an excipient with a known effect. Denivert W is also approved for its use in food products as a humectant, crystallization modifier, and liquid and nutritive sweetener.
Toxicity
Denivert W is a generally accepted safe substance and it does not present toxic effects. Do not administer invert sugar in patients with the rare hereditary problems of fructose intolerance, glucose-galactose malabsorption or sucrose-isomaltase insufficiency. It is also recommended to take precautions in patients that present diabetes mellitus.
Elimination Route
It has been reported that administration of 10-15% of intravenous invert sugar solution is rapidly absorbed in the intestine and distributed in blood without exceeding the renal threshold. The absorption of invert sugar happens mainly as monosaccharides. Glucose is absorbed into the portal vein by the transporter GLUT2 while fructose is absorbed by the transporter GLUT5.
Half Life
The glucose half-life following intravenous administration of invert sugar is of approximately 30 min. In the same report, the half-life of fructose after the intravenous administration is reported to be 16 min.
Elimination Route
Reports have indicated that after intravenous administration of invert sugar present a reduced content or carbohydrates in urine when compared to the intravenous administration of glucose. This response indicates a reduced diuresis of invert sugar. It has also been reported a reduced diuresis in the presence of invert diuresis.
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