Denovo

Denovo Uses, Dosage, Side Effects, Food Interaction and all others data.

Doxylamine is a first-generation antihistamine. It can be used by itself as a short-term sedative and in combination with other drugs to provide night-time allergy and cold relief. Doxylamine is also used in combination with the analgesics paracetamol (acetaminophen) and codeine as an analgesic/calmative preparation, and is prescribed in combination with vitamin B6 (pyridoxine) to prevent morning sickness in pregnant women.

Doxylamine is an antihistamine derived from monoethanolamine possessing antimuscarinic and pronounced sedative effects.

Doxylamine is an antihistamine commonly used as a sleep aid. This drug is also used to relieve symptoms of hay fever (allergic rhinitis), hives (rash or itching), and other allergic reactions. Doxylamine is a member of the ethanolamine class of antihistamines and has anti-allergy power far superior to virtually every other antihistamine on the market, with the exception of diphenhydramine (Benadryl). It is also the most powerful over-the-counter sedative available in the United States, and more sedating than many prescription hypnotics. In a study, it was found to be superior to even the barbiturate, phenobarbital for use as a sedative. Doxylamine is also a potent anticholinergic.

Denovo
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Denovo
Generic	Doxylamine + Folic Acid [vit B9] + Pyridoxine [vit B6]
Weight	15mg, 7.5mg, 15mg, 7.5mg, 30mg
Type	Tablet, Oral Capsule, Oral Tablet, Extended Release
Therapeutic Class
Manufacturer	Vance & Health Pharmaceuticals Ltd
Available Country	India, United States
Last Updated:	September 19, 2023 at 7:00 am

Uses

Doxylamine is used for Hypersensitivity reactions, Insomnia

Denovo is also used to associated treatment for these conditions: Common Cold, Flu Symptoms, Insomnia, Mild Allergic Rhinitis, Nausea, Vomiting

How Denovo works

Like other antihistamines, doxylamine acts by competitively inhibiting histamine at H1 receptors. It also has substantial sedative and anticholinergic effects.

Dosage

Denovo dosage

Hypersensitivity reactionn: 25 mg every 4-6 hr. Max: 150 mg daily.

Insomnia: 25 mg given 30 minutes before retiring at night.

Should be taken with food. Take with food or milk.

Side Effects

Acute dystonic reactions and long-lasting impaired consciousness in child. CNS depression including slight drowsiness to deep sleep, lassitude, dizziness, incoordination. Headache, psychomotor impairment and antimuscarinic effects. Rarely rashes and hypersensitivity reactions, blood disorders, convulsions, sweating, myalgia, extrapyramidal effects, tremor, confusion, tinnitus, hypotension, hair loss.

Toxicity

Signs of overdose include wheezing, tightness in the chest, fever, itching, bad cough, blue skin color, fits, swelling of face, lips, tongue, or throat.

Precaution

May impair ability to drive and operate machinery. Angle-closure galucoma, urinary retention, prostatic hypertrophy or pyloroduodenal obstruction; epilepsy; hepatic impairment. Elderly. Lactation.

Interaction

Enhance effects of CNS depressants eg alcohol, barbiturates, hypnotics, opioid analgesics, anxiolytic sedatives and antipsychotics. Atropine, TCAs, MAOIs. Can mask signs of ototoxicity caused by aminoglycosides.

Elimination Route

Readily absorbed via the gastrointestinal tract.

Half Life

10 hours

Pregnancy & Breastfeeding use

Category A: Controlled studies in women fail to demonstrate a risk to the fetus in the 1st trimester (and there is no evidence of a risk in later trimesters), and the possibility of fetal harm remains remote.