Densa

Densa Uses, Dosage, Side Effects, Food Interaction and all others data.

A topical anti-infective agent effective against gram-negative and gram-positive bacteria. It is used for superficial wounds, burns, ulcers, and skin infections. Nitrofurazone has also been administered orally in the treatment of trypanosomiasis.

Nitrofurazone is a topical antibacterial agent indicated as an adjunctive therapy for second and third degree burns when resistance to other agents is a real or potential problem. Nitrofurazone is also indicated in skin grafting when bacterial contamination may cause graft rejection or donor site infection, especially in hospitals with a history of resistant bacteria.

Table Of contents

• Densa
• Uses
• Dosage
• Side Effect
• Precautions
• Interactions
• Uses during Pregnancy
• Uses during Breastfeeding
• Accute Overdose
• Food Interaction
• Half Life
• Volume of Distribution
• Clearance
• Interaction With other Medicine
• Contradiction
• Storage

Trade Name	Densa
Generic	Nitrofural
Nitrofural Other Names	Furacilin, Nitrofural
Type
Formula	C6H6N4O4
Weight	Average: 198.1362 Monoisotopic: 198.0389047
Groups	Approved, Investigational, Vet approved
Therapeutic Class
Manufacturer
Available Country	Thailand
Last Updated:	September 19, 2023 at 7:00 am

Uses

Densa is a topical antibacterial for the prevention and treatment of bacterial infections of the skin.

For the treatment of bacterial skin infections including pyodermas, infected dermatoses and infections of cuts, wounds, burns and ulcers due to susceptible organisms.

Densa is also used to associated treatment for these conditions: Skin Infections

How Densa works

The exact mechanism of action is unknown. Nitrofurazone inhibits several bacterial enzymes, especially those involved in the aerobic and anaerobic degradation of glucose and pyruvate. This activity is believed also to affect pyruvate dehydrogenase, citrate synthetase, malate dehydrogenase, glutathione reductase, and pyruvate decarboxylase.

Toxicity

Rat LD₅₀ = 590 mg/kg; Allergic contact dermatitis is the most frequently reported adverse effect, occurring in approximately 1 % of patients treated.

Elimination Route

Well absorbed.

Half Life

5 hours

Innovators Monograph

You find simplified version here Densa