Dentonin
Dentonin Uses, Dosage, Side Effects, Food Interaction and all others data.
Dentonin is a novel synthetic peptide derived from an endogenous human protein produced by bone and dental cells (a fragment from matrix extracellular phosphoglycoprotein). It is being developed by Acologix, Inc.
In animal models, Dentonin promoted cartilage regeneration. In the study, goats with an osteochondral femoral condylar (knee cartilage) defect were used to evaluate the effects of Dentonin on cartilage regeneration. Cylindrical defects were created in the knee cartilage and were filled with a collagen sponge containing Dentonin at two different doses or a collagen sponge soaked in saline (control group). Post-operative treatments included intra-articular injections of the test articles into the operated knee joint at weeks one, two and three post surgery. Cartilage regeneration was evaluated in one group after 84 days and 168 days in another group. The results demonstrated that the application of Dentonin dose dependently promoted cartilage defect repair. The groups treated with the higher dosage of Dentonin had greater healing outcome scores than the saline control groups. As there was no evidence of an inflammatory response, Dentonin demonstrated a favorable safety profile in the study.
| Trade Name | Dentonin |
| Generic | AC-100 |
| Type | |
| Groups | Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Investigated for use/treatment in periodontal disease.
How Dentonin works
In several preclinical models, Dentonin has demonstrated potent and selective dental tissue and bone formation activity, however the exact mechanism is not known. One study (PMID:15153459) showed that Dentonin enhances dental pulp stem cell (DPSC) proliferation by down-regulating P16, accompanied by up-regulation of ubiquitin protein ligase E3A and human ubiquitin-related protein SUMO-1. Enhanced cell proliferation required intact RGD and SGDG motifs in the peptide. This study shows that Dentonin can promote DPSC proliferation, with a potential role in pulp repair.
Innovators Monograph
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