Derma Cote

Derma Cote Uses, Dosage, Side Effects, Food Interaction and all others data.

Isopropyl myristate is a moisturizer with polar characteristics used in cosmetics and topical medical preparations to ameliorate the skin absorption. Isopropyl myristate has been largely studied and impulsed as a skin penetration enhancer.

At the moment the primary usage for which isopropyl myristate is formally indicated is as the active ingredient in a non-prescription pediculicide rinse .

Isopropyl myristate is an emollient vehicle that is effective at enhancing the penetration of other medical agents that may be incorporated into the vehicle as active agents . In one study, a 50:50 isopropanol-isopropyl myristate binary enhancer synergistically increased the transport of estradiol across a two-layer human epidermis in vitro .

Derma Cote
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Derma Cote
Generic	Cyclopentasiloxane + Trimethylsiloxysilicate + Dimethicone Crospolymer + Isopropyl Myristate + Dimethicone Crosspolymer + Dimethiconol Hydroxystearate + Cyclotetrasiloxane.
Type	Gel
Therapeutic Class
Manufacturer	Galenium Pharmasia Lab, Prima Medika Lab
Available Country	Indonesia
Last Updated:	September 19, 2023 at 7:00 am

Uses

Isopropyl myristate is a polar skin moisturizer that is used to enhance skin penetration of drugs.

The primary medical indication for which isopropyl myristate is formally used as an active ingredient in a patient care product is as a non-prescription pediculicide rinse .

Derma Cote is also used to associated treatment for these conditions: Head Lice Infestation

How Derma Cote works

As a pediculicide, isopropyl myristate is capable of physically coating the exoskeleton bodies of lice . This physical coating subsequently immobilizes the lice and works to dissolve the wax covering on the insect exoskeleton and blocks the insects' airways, leading to death by dehydration . Although this physical action of isopropyl myristate results in little lice resistance (given the lack of immunologic or chemical activity in this mechanism of action), the substance is also not ovicidal, which means any eggs that may have been laid by lice would not be affected . Moreover, isopropyl myristate is capable of eliciting its pediculicide action in a contact time of only 10 minutes per each necessary administration .

Toxicity

Readily available information regarding the pharmacokinetics of isopropyl myristate is not available .

Volume of Distribution

Readily available information regarding the pharmacokinetics of isopropyl myristate is not available .

Elimination Route

Dermal absorption of isopropyl myristate is predicated to be 0.00020 mg/cm2/event, which is considered a very low absorption rate . In a study, topically applied isopropyl myristate was largely retained in the stratum corneum . It was not detected in the receptor fluid of flow-through diffusion cells in in-vitro skin permeation experiments using human epidermis (stratum corneum and viable epidermis) and dermis of varying thickness .