Dermatop 0.25%

Dermatop 0.25% Uses, Dosage, Side Effects, Food Interaction and all others data.

Dermatop 0.25% is a relatively new topical corticosteroid drug that displays a similar potency as hydrocortisone. It is used in the treatment of inflammatory skin diseases, such as atopic dermatitis. It has a favorable benefit-risk ratio, with an inflammatory action similar to that of a medium potency corticosteroid, but with a low potential to cause skin atrophy. The anti-inflammation action of corticosteroids is associated with the inhibition of the interleukin 1-alpha cytokine within keratinocytes. IL-1a is also found in fibroblasts, where it is responsible for proliferation, collagenase induction and IL-6 synthesis, which are related to skin thickness.

Corticosteroids diffuse across cell membranes and complex with specific cytoplasmic receptors. These complexes then enter the cell nucleus, bind to DNA (chromatin), and stimulate transcription of messenger RNA (mRNA) and subsequent protein synthesis of various inhibitory enzymes responsible for the anti-inflammatory effects of topical corticosteroids. These anti-inflammatory effects include inhibition of early processes such as edema, fibrin deposition, capillary dilatation, movement of phagocytes into the area, and phagocytic activities. Later processes, such as capillary production, collagen deposition, and keloid formation also are inhibited by corticosteroids.

Dermatop 0.25%
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Trade Name	Dermatop 0.25%
Generic	Prednicarbate
Prednicarbate Other Names	Prednicarbate, Prednicarbato
Type
Formula	C₂₇H₃₆O₈
Weight	Average: 488.577 Monoisotopic: 488.241018119
Groups	Approved, Investigational
Therapeutic Class
Manufacturer
Available Country	Egypt
Last Updated:	September 19, 2023 at 7:00 am

Uses

Dermatop 0.25% is a medium potency topical corticosteroid used to manage pruritus and inflammation associated with responsive skin conditions.

For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.

Dermatop 0.25% is also used to associated treatment for these conditions: Dermatosis

How Dermatop 0.25% works

In common with other topical corticosteroids, prednicarbate has anti-inflammatory, antipruritic, and vasoconstrictive properties. In general, the mechanism of the anti-inflammatory activity of topical steroids is unclear. However, corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2.