Desacetyllanatoside C

Desacetyllanatoside C Uses, Dosage, Side Effects, Food Interaction and all others data.

Deacetyllanatoside C. A cardiotonic glycoside from the leaves of Digitalis lanata.

Desacetyllanatoside C is a cardiac glycoside used to treat congestive heart failure and supraventricular arrhythmias due to reentry mechanisms, and to control ventricular rate in the treatment of chronic atrial fibrillation.

Table Of contents

• Desacetyllanatoside C
• Uses
• Dosage
• Side Effect
• Precautions
• Interactions
• Uses during Pregnancy
• Uses during Breastfeeding
• Accute Overdose
• Food Interaction
• Half Life
• Volume of Distribution
• Clearance
• Interaction With other Medicine
• Contradiction
• Storage

Trade Name	Desacetyllanatoside C
Generic	Deslanoside
Deslanoside Other Names	Deacetyllanatoside C, Desacetyllanatoside C, Deslanoside, Deslanosido, Deslanosidum, Glucodigoxin
Type
Formula	C47H74O19
Weight	Average: 943.0791 Monoisotopic: 942.482430186
Protein binding	20%
Groups	Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

For the treatment and management of Congestive cardiac insufficiency, arrhythmias and heart failure.

How Desacetyllanatoside C works

Desacetyllanatoside C inhibits the Na-K-ATPase membrane pump, resulting in an increase in intracellular sodium and calcium concentrations. Increased intracellular concentrations of calcium may promote activation of contractile proteins (e.g., actin, myosin). Desacetyllanatoside C also acts on the electrical activity of the heart, increasing the slope of phase 4 depolarization, shortening the action potential duration, and decreasing the maximal diastolic potential.

Toxicity

Symptoms of overdose include ventricular tachycardia, ventricular fibrillation, progressive bradyarrhythmias, or heart block.

Elimination Route

Little absorption from the gastrointestinal tract (40%).

Half Life

36 hours

Innovators Monograph

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