Desacetylvinblastine Amide

Desacetylvinblastine Amide Uses, Dosage, Side Effects, Food Interaction and all others data.

Vinblastine derivative with antineoplastic activity against cancer. Major side effects are myelosuppression and neurotoxicity. Desacetylvinblastine Amide is used extensively in chemotherapy protocols (antineoplastic combined chemotherapy protocols).

Desacetylvinblastine Amide is indicated for the treatment of acute lymphocytic leukemia of childhood that is resistant to vincristine and non-oat cell lung cancer. Desacetylvinblastine Amide causes the arrest of cells in metaphase mitosis. It is three times more potent than vincristine and nearly 10 times more potent than vinblastine in causing mitotic arrest in in vitro studies at doses designed to arrest from 10 to 15% of the cells in mitosis. Desacetylvinblastine Amide and vincristine are approximately equipotent at dose levels that arrest 40 to 50% of the cells in mitosis. Unlike vinblastine, vindesine produces very few postmetaphase cells. Desacetylvinblastine Amide has demonstrated activity in patients who have relapsed while receiving multiple-agent treatment that included vincristine.

Desacetylvinblastine Amide
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
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Volume of Distribution
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Interaction With other Medicine
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Trade Name	Desacetylvinblastine Amide
Generic	Vindesine
Vindesine Other Names	Desacetylvinblastine amide, Vindesina, Vindesine, Vindesinum
Type
Formula	C₄₃H₅₅N₅O₇
Weight	Average: 753.941 Monoisotopic: 753.410149131
Protein binding	65-75%
Groups	Approved, Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Desacetylvinblastine Amide is a vinca alkaloid derived from vinblastine used for various types of malignancies, but mainly acute lymphocytic leukemia (ALL).

For the treatment of acute leukaemia, malignant lymphoma, Hodgkin's disease, acute erythraemia and acute panmyelosis

Desacetylvinblastine Amide is also used to associated treatment for these conditions: Acute Lymphocytic Leukemia (ALL), Blast Crisis, Melanoma, Malignant

How Desacetylvinblastine Amide works

Desacetylvinblastine Amide acts by causing the arrest of cells in metaphase mitosis through its inhibition tubulin mitotic funcitoning. The drug is cell-cycle specific for the S phase.

Food Interaction

Exercise caution with grapefruit products. Desacetylvinblastine Amide is metabolized by CYP3A4, and grapefruit inhibits CYP3A4 metabolism, which may increase vindesine serum levels.
Exercise caution with St. John's Wort. Desacetylvinblastine Amide is metabolized by CYP3A4 and this herb induces CYP3A4 metabolism, which may reduce vindesine serum levels.