Desoxycholsäure
Desoxycholsäure Uses, Dosage, Side Effects, Food Interaction and all others data.
Desoxycholsäure is a a bile acid which emulsifies and solubilizes dietary fats in the intestine, and when injected subcutaneously, it disrupts cell membranes in adipocytes and destroys fat cells in that tissue. In April 2015, deoxycholic acid was approved by the FDA for the treatment submental fat to improve aesthetic appearance and reduce facial fullness or convexity. It is marketed under the brand name Kybella by Kythera Biopharma and is the first pharmacological agent available for submental fat reduction, allowing for a safer and less invasive alternative than surgical procedures.
| Trade Name | Desoxycholsäure |
| Generic | Deoxycholic acid |
| Deoxycholic acid Other Names | Deoxycholate, Deoxycholic acid, Desoxycholic acid, Desoxycholsäure |
| Type | |
| Formula | C24H40O4 |
| Weight | Average: 392.572 Monoisotopic: 392.292659768 |
| Protein binding | 98% |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Desoxycholsäure is a cytolytic agent injected subcutaneously to improve the appearance submental fat.
For improvement in appearance of moderate to severe fullness associated with submental fat in adults.
Desoxycholsäure is also used to associated treatment for these conditions: Submental fat removal
How Desoxycholsäure works
As a bile acid, deoxycholic acid emulsifies fat in the gut. Synthetically derived deoxycholic acid, when injected, stimulates a targeted breakdown of adipose cells by disrupting the cell membrane and causing adipocytolysis. This results in an inflammatory reaction and clearing of the adipose tissue remnants by macrophages. Desoxycholsäure's actions are reduced by albumin and tissue-associated proteins, therefore its effect is limited to protein-poor subcutaneous fat tissue. Protein-rich tissues like muscle and skin are unaffected by deoxycholic acid, contributing to its safety profile.
Food Interaction
No interactions found.Elimination Route
Desoxycholsäure is rapidly absorbed after subcutaneous administration. After maximum recommended single treatment dose, 100mg, the post-treatment plasma levels returned to endogenous levels within 24 hours. With the proposed treatment guideline, no accumulation is expected.
Elimination Route
The exogenous deoxycholic acid joins the endogenous bile acid pool in the enterohepatic circulation and is excreted unchanged in feces along with endogenous deoxycholic acid.
Innovators Monograph
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