Dexferrum
Dexferrum Uses, Dosage, Side Effects, Food Interaction and all others data.
Iron dextran is a dark brown, slightly viscous liquid complex of ferric hydroxide and dextran for intravenous or intramuscular use. Dexferrum is used for the treatment of patients with documented iron deficiency in which oral administration is unsatisfactory or impossible.
Iron dextran is a dark brown, slightly viscous sterile liquid complex of ferric hydroxide and dextran for intravenous or intramuscular use. It is for treatment of patients with documented iron deficiency in whom oral administration is unsatisfactory or impossible. Iron is essential to the formation of hemoglobin and to the function and formation of other heme and nonheme compounds. Untreated depletion of iron stores leads to iron-deficient erythropoiesis and, in turn, to iron deficiency anemia.
| Trade Name | Dexferrum |
| Generic | Iron Dextran |
| Iron Dextran Other Names | Dextran iron, Iron Dextran, Iron dextran complex |
| Weight | 50mg/ml |
| Type | Injection, Injectable Solution |
| Protein binding | 100% (after release from dextran) |
| Groups | Approved, Vet approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | United States |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Dexferrum is an iron supplement used to treat iron deficiency in patients who cannot take oral iron.
For treatment of patients with documented iron deficiency in whom oral administration is unsatisfactory or impossible. Also used to replenish body iron stores in Non-Dialysis Dependent-Chronic Kidney Disease (NDD-CKD) patients receiving or not receiving erythropoietin and in Hemodialysis Dependent (HDD-CKD) and Peritoneal Dialysis Dependent (PDD-CKD) - Chronic Kidney Disease patients receiving an erythropoietin.
Dexferrum is also used to associated treatment for these conditions: Iron Deficiency (ID)
How Dexferrum works
After iron dextran is injected, the circulating iron dextran is removed from the plasma by cells of the reticuloendothelial system, which split the complex into its components of iron and dextran. The iron is immediately bound to the available protein moieties to form hemosiderin or ferritin, the physiological forms of iron, or to a lesser extent to transferrin. This iron which is subject to physiological control replenishes hemoglobin and depleted iron stores.
Toxicity
LD50 = 500 mg/kg (mouse, IV). Dosages of iron dextran in excess of the requirements for restoration of hemoglobin and replenishment of iron stores may lead to hemosiderosis. Cases of severe, sometimes fatal, allergic reactions (loss of consciousness, collapse, difficulty breathing, hives, swelling, or convulsions) and severe low blood pressure (hypotension) have been reported with the use of iron dextran.
Food Interaction
No interactions found.Elimination Route
The major portion of intramuscular injections of iron dextran is absorbed within 72 hours; most of the remaining iron is absorbed over the ensuing 3 to 4 weeks.
Half Life
5 hours (some indications that it can be as long as 10 hours)
Elimination Route
Dextran, a polyglucose, is either metabolized or excreted.
Innovators Monograph
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