Dexogum

Dexogum Uses, Dosage, Side Effects, Food Interaction and all others data.

Tannic acid is a polyphenolic compound. It is a type of the commercially available tannins. It acts as a weak acid. Tannic acid is found in the nutgalls formed by insects on twigs of certain oak trees (Quercus infectoria and other Quercus species). It is removed and used as medicine. In the old days it was used as antidote against different poisons.Nowadays, tannic acid is applied topically for the treatment of cold sores, diaper rash, fever blisters and poison ivy. Tannic acid is also taken by mouth and applied directly for bleeding, chronic diarrhea, dysentery, bloody urine, painful joints, persistent coughs, and cancer.

Zinc chloride is a solution of ions indicated for use in total parenteral nutrition to maintain zinc levels and prevent deficiency syndromes.

Zinc chloride was granted FDA approval before 26 June 1986.

Zinc is a cofactor in many enzymes and mediates a number of catalytic, structural, and regulatory roles in the body. It has a wide therapeutic index and long duration of action, as most zinc in the body is reabsorbed. Patients should be counselled regarding the risk of administration in patients with severe kidney dysfunction.

Dexogum
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Dexogum
Generic	Tannic Acid + Zinc Chloride + Cetrimide
Weight	2%w/v
Type	GuPaint
Therapeutic Class
Manufacturer	Nicks Laboratories
Available Country	India
Last Updated:	September 19, 2023 at 7:00 am

Uses

Tannic acid is indicated for cold sores, fever blisters, diaper rash, minor burn or sunburn and prickly heat. Vaginally, tannic acid is used as a douche for leukorrhea. It has been also indicated for sore throat, inflamed tonsils, spongy or receding gums, and acute dermatitis.

Zinc chloride is a medication used to treat zinc deficiencies and associated symptoms and also in total parenteral nutrition.

Zinc chloride injections are indicated for use total parenteral nutrition to maintain zinc serum levels and prevent deficiency syndromes.

Dexogum is also used to associated treatment for these conditions: Dietary Supplementations

How Dexogum works

Pharmaceutical grade tannic acid is generally considered to be pentadigalloylglucose. It has an astringent effect. When used internally, it dehydrates tissues when cause reduction in secretions. Externally, it works through formation of protective layer of harder and constricted cells. Tannic acid is thought to exert antiviral and antibacterial effects.

Zinc performs catalytic, structural, and regulatory roles in the body. Zinc is a component of approximately 3000 human proteins.

Zinc is cytoprotective against reactive oxygen species mediated apoptosis through the action of metallothioneins.

In a promyelocytic leukemia cell line, zinc enhances the up-regulation of A20 mRNA, which, via the TRAF pathway, decreases NF-kappaB activation, leading to decreased gene expression and generation of TNF-α, IL-1β, and IL-8 .

In patients with diarrhea, zinc restores mucosal barrier integrity, restores enterocyte brush-border enzyme activity, promotes the production of antibodies, and promotes the production of circulating lymphocytes against intestinal pathogens. Zinc also directly affects ion channels as a potassium channel blocker of cAMP-mediated chlorine secretion.

Zinc deficiency decreases thymulin, inhibiting T-helper cell maturation and decreased Th-1 cytokines like IL-2. Decreased IL-2 decreases the activity of NK cells and CD8+ T cells. Zinc deficiency also leads to the generation of CD4+ T cells, decreased NF-κB activation, decreased phosphorylation of IκB, and decreased binding of NF-κB to DNA.

Toxicity

LD50 is 2.26 g/Kg in rats.

Patients experiencing and overdose may present with hypotension, pulmonary edema, diarrhea, vomiting, jaundice, and oligouria. Overdose can be managed through symptomatic and supportive treatment which may include sodium calcium edetate and analgesics.

The oral LD₅₀ in mice is 329 mg/kg and in rats is 350 mg/kg.

Elimination Route

After ingestion it has poor bioavailability, due to large size, high affinity to bound to plasma proteins and low lipid solubility. Its main actions are due to local effects.

Zinc is approximately 33% orally bioavailable in humans but bioavailability can vary between patients and depending on current zinc levels. Further data regarding the pharmacokinetics of zinc chloride are not readily available.