Dfriz

Dfriz Uses, Dosage, Side Effects, Food Interaction and all others data.

Glucosamine is a natural substance produced in the human body and found in certain foods. Glucosamine stimulates the production of glycosaminoglycan & proteoglycan, two essential building blocks of cartilage. Glucosamine acts, as a supplement, as a joint lubricant and shock absorber necessary to maintain healthy cartilage and joint function.

Diacerein is an anti-inflammatory analgesic and antipyretic drug, indicated specially for the treatment of arthritic conditions. It directly inhibits IL-1 synthesis and release in vitro and down modulates IL-1 induced activities and relieves Osteoarthritis.

Trade Name Dfriz
Generic Diacerein + Glucosamine Sulphate
Type Tablet
Therapeutic Class Stimulation of Cartilage formation
Manufacturer Sinsan Pharmaceuticals
Available Country India
Last Updated: September 19, 2023 at 7:00 am
Dfriz
Dfriz

Uses

This is primarily used for conditions like Osteoarthritis, Rheumatoid arthritis, Bone & Joint injuries.

Dfriz is also used to associated treatment for these conditions: Osteoarthritis in the Hip Joint, Osteoarthritis of the Knee

How Dfriz works

Diacerein's active metabolite rhein Rhein reduces cartilage destruction by decreasing expression of matrix metalloproteinase (MMP)-1 and -3 as well as upregulating tissue inhibitor of matrix metalloproteinases which serve to reduce the activity of several MMPs . The anti-inflammatory action of rhein reduces the level of interleukin-1beta activity which plays a large role in reduction of extracellular matrix production, MMP activity, and continued inflammation . Rhein reduces abnormal osteoblast synthetic activity through an unknown mechanism .

Dosage

Dfriz dosage

Adult & Children above 12 years: One tablet (Diacerein50 mg & Glucosamine Sulphate750 mg) twice daily for 4-12 weeks, taken with food.

Creatinine Clearance(CrCl) < 30 ml/min: The dose of Diacerein to be reduced.

Side Effects

Diarrhea, constipation, epigastric pain, heart burn, nausea, vomiting, headache, skin rashes, drowsiness, intense yellow coloring of urine.

Toxicity

Rhein Rhein has an oral LD50 of >5000mg/kg in mice. This is equivalent to a diacerein dose of >6476mg/kg.

Precaution

Caution should be practiced when administering Glucosamine + Diacerein in those patients who are allergic to Glucosamine and/or Diacerein or to shellfish (e.g., shrimp, crab); who have diabetes, asthma, alcohol dependence or liver disease. Before taking Glucosamine + Diacerein complete blood count, liver function and urinalysis should be monitored regularly.

Interaction

There have been no reports of significant drug interactions of Glucosamine with antibiotics/ antidepressants/ antihypertensives/ nitrates/ antiarrythmics/ anxiolytic/ hypoglycemic agents/ antisecretives. But decreased absorption of Diacerein with aluminium and/ or magnesium hydroxide antacids. Increased risk of diarrhea with laxatives, antibiotics. Avoid co-administration with fibres and phytic acids.

Volume of Distribution

15-60L .

Elimination Route

Bioavailability of 50-60% . Entirely converted to the active metabolite rhein Rhein before reaching systemic circulation.

Half Life

4-10h .

Clearance

Total CL is 1.5L/h and renal CL is 0.1L/h .

Elimination Route

37% excreted in urine and 53% in feces as estimated in rats .

Pregnancy & Breastfeeding use

Diacerein is contraindicated in pregnancy and lactation. Glucosamine should not be taken by pregnant women and nursing mothers due to lack of scientific data regarding its effect on fetus and infants.

Contraindication

There are no known contraindications for Glucosamine. But proven hypersensitivity to Glucosamine is a contraindication. Diabetics are advised to monitor blood glucose levels regularly when taking Glucosamine. No special studies were formed in patients with renal and/or hepatic insufficiency. The toxicological and pharmacokinetic profile of Glucosamine does not indicate limitations for these patients. However, administration to patients with severe hepatic or renal insufficiency should be under appropriate medical supervision. Children should not be supplemented with Glucosamine. Diacerein or to shellfish (e.g., shrimp, crab); who have diabetes, asthma, alcohol dependence or liver disease. While taking the drug complete blood count, liver function and urinalysis should be monitored regularly. Diacerein is contraindicated in pregnancy, lactation and hypersensitivity to anthraquinone derivatives.

Acute Overdose

Diarrhea may occur.

Storage Condition

Store in a cool & dry place, protect from light & moisture.

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*** Taking medicines without doctor's advice can cause long-term problems.
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