Diacéréine Cristers
Diacéréine Cristers Uses, Dosage, Side Effects, Food Interaction and all others data.
Diacéréine Cristers is a prodrug which is metabolized to rhein. It is currently approved in France for the treatment of osteoarthritis although the use of diacerein is restricted due to the side effects including severe diarrhea . Diacéréine Cristers is under investigation for the treatment of Insulin Resistance, Diabetes Mellitus (Type 2), and Diabetes-Related Complications.
Decreases inflammation and cartilage destruction and also corrects altered osteoblast acitivity .
| Trade Name | Diacéréine Cristers |
| Generic | Diacerein |
| Diacerein Other Names | Diacerein, Diacereína |
| Type | |
| Formula | C19H12O8 |
| Weight | Average: 368.297 Monoisotopic: 368.053217346 |
| Protein binding | 99% of rhein is bound to plasma proteins . |
| Groups | Approved, Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | France |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Diacéréine Cristers is an slow-onset anthraquinone IL-1 inhibitor used in the treatment of degenerative joint diseases like osteoarthritis.
For the treatment of osteoarthritis affecting the hip or knee .
Diacéréine Cristers is also used to associated treatment for these conditions: Osteoarthritis in the Hip Joint, Osteoarthritis of the Knee
How Diacéréine Cristers works
Diacéréine Cristers's active metabolite rhein Rhein reduces cartilage destruction by decreasing expression of matrix metalloproteinase (MMP)-1 and -3 as well as upregulating tissue inhibitor of matrix metalloproteinases which serve to reduce the activity of several MMPs . The anti-inflammatory action of rhein reduces the level of interleukin-1beta activity which plays a large role in reduction of extracellular matrix production, MMP activity, and continued inflammation . Rhein reduces abnormal osteoblast synthetic activity through an unknown mechanism .
Toxicity
Rhein Rhein has an oral LD50 of >5000mg/kg in mice. This is equivalent to a diacerein dose of >6476mg/kg.
Volume of Distribution
15-60L .
Elimination Route
Bioavailability of 50-60% . Entirely converted to the active metabolite rhein Rhein before reaching systemic circulation.
Half Life
4-10h .
Clearance
Total CL is 1.5L/h and renal CL is 0.1L/h .
Elimination Route
37% excreted in urine and 53% in feces as estimated in rats .
Innovators Monograph
You find simplified version here Diacéréine Cristers
FAQ
What is Diacéréine Cristers used for?
Diacéréine Cristers is a slow-acting medicine of the class anthraquinone used to treat joint diseases such as osteoarthritis.
How safe is Diacéréine Cristers?
Diacéréine Cristers is safe, apart from a substantially higher risk of diarrhoea, especially with longer-term use.Diacéréine Cristers has an acceptable safety profile, particularly in comparison with that of NSAIDs and paracetamol. The ESCEO positions Diacéréine Cristers as a first-line pharmacological background treatment of osteoarthritis.
How does Diacéréine Cristers work?
Diacéréine Cristers works by blocking the actions of interleukin-1 beta, a protein involved in the inflammation and destruction of cartilage that plays a role in the development of symptoms of degenerative joint diseases such as osteoarthritis.
What are the common side effects of Diacéréine Cristers?
Common side effects of Diacéréine Cristers are include:
- Diarrhoea.
- Stomach discomfort and pain.
- Nausea.
- Vomiting.
- Yellowing of skin and eyes.
- Urine discoloration.
- Increase in liver enzyme levels.
- Allergic skin reaction.
Is Diacéréine Cristers safe during pregnancy?
Diacéréine Cristers should not be administered during pregnancy.
Is Diacéréine Cristers safe during breastfeeding?
Diacéréine Cristers should not be administered during lactation.
Can I drink alcohol with Diacéréine Cristers?
Patients should be advised to limit their alcohol intake while on treatment with Diacéréine Cristers.
Can I drive after taking Diacéréine Cristers?
Diacéréine Cristers may cause dizziness and drowsiness. So if you observe such symptoms, then do not drive.
When should be taken of Diacéréine Cristers?
The recommended starting dose is 50 mg once daily with evening meal for the first 2 to 4 weeks of treatment, after which the recommended daily dose is 50 mg twice daily.
Can I take Diacéréine Cristers on an empty stomach?
The Diacéréine Cristers should be taken with food, one with breakfast and the other with evening meal.
How often can I take Diacéréine Cristers?
The recommended dose is 50 mg to be taken twice daily.
How long does Diacéréine Cristers take to work ?
Diacéréine Cristers starts showing its action in 2-3 hours. The duration of action of Diacéréine Cristers is 27 hours
How long can Diacéréine Cristers be taken?
The duration of action of Diacéréine Cristers is 27 hours.
Who should not take Diacéréine Cristers?
Diacéréine Cristers should not be used in any patient with liver disease or a history of liver disease, and doctors should be monitoring their patients for early signs of liver problems.
Is Diacéréine Cristers an antibiotic?
Diacéréine Cristers is a novel antibacterial agent; the antibacterial breakpoint could not be found in the literature or in standards.
What happen If I missed a dose of Diacéréine Cristers?
If you forget to take a dose of Diacéréine Cristers, make sure that you remember to take your next dose when it is due. Do not take two doses together to make up for a missed dose.
What happen if I overdose on Diacéréine Cristers?
Never take more than the prescribed dose. Seek emergency medical treatment or contact the doctor if you suspect that you might have taken an overdose of Diacéréine Cristers.
Can Diacéréine Cristers causes diarrhoea?
Diacéréine Cristers may cause diarrhoea or loose stools in the first few days of treatment. Contact your doctor if the diarrhoea does not stop within 3-4 days.
Who should not take Diacéréine Cristers?
Avoid taking Diacéréine Cristers if you are allergic to it. Seek medical attention if you notice any allergic reactions such as skin rash, hives (painful, itchy eruptions that sting), swelling (face, lips, tongue, etc.), breathing difficulty, etc. Diacéréine Cristers is excreted through the kidneys.
If you have pre-existing kidney problems, this medicine may accumulate in your kidneys and further worsen your condition. Hence, this medicine is not recommended for use if you have kidney problems.
Can Diacéréine Cristers affects my heart ?
Diacéréine Cristers Improves Left Ventricular Remodeling and Cardiac Function by Reducing the Inflammatory Response after Myocardial Infarction.
Does Diacéréine Cristers cause kidney damage?
Diacéréine Cristers has shown to be safe and effective in patients with moderate to severe renal impairment, and dose adjustment is not required in these patients.
Can Diacéréine Cristers affects my liver?
Around 0.5% of patients on Diacéréine Cristers had some kind of liver reaction, with most cases being mild, reversible increases in serum transaminases.
