Diazossido
Diazossido Uses, Dosage, Side Effects, Food Interaction and all others data.
A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group.
Diazossido is a potassium channel activator. Its mechanism of action revolves around enhancing cell membrane permeability to potassium ions. This action consequently elicits the relaxation of local smooth muscles. This switches off voltage-gated calcium ion channels which inhibits the generation of an action potential.
| Trade Name | Diazossido |
| Availability | Prescription only |
| Generic | Diazoxide |
| Diazoxide Other Names | Diazossido, Diazoxide, Diazoxido, Diazoxidum |
| Related Drugs | hydralazine, nifedipine, captopril, enalapril, labetalol, glucagon, methyldopa, Baqsimi, Gvoke, GlucaGen |
| Type | |
| Formula | C8H7ClN2O2S |
| Weight | Average: 230.671 Monoisotopic: 229.991675875 |
| Protein binding | Very high (more than 90%) to serum proteins. |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Diazossido is a non diuretic benzothiadiazine indicated for the management of hypoglycemia in patients who produce an excess of insulin caused by a variety of conditions.
Used parentally to treat hypertensive emergencies. Also used to treat hypoglycemia secondary to insulinoma.
Diazossido is also used to associated treatment for these conditions: Hyperinsulinemic Hypoglycemia
How Diazossido works
Diazossido inhibits insulin release from the pancreas, by opening potassium channels in the beta cell membrane. Diazossido is chemically related to thiazide diuretics but does not inhibit carbonic anhydrase and does not have chloriuretic or natriuretic activity. It also exhibits hypotensive activity by reducing arteriolar smooth muscle and vascular resistance.
Toxicity
Oral LD50 in rat and mouse: 980 mg/kg and 444 mg/kg, respectively.
Food Interaction
No interactions found.Diazossido Drug Interaction
Unknown: amphetamine / dextroamphetamine, amphetamine / dextroamphetamine, epinephrine, epinephrine, pancrelipase, pancrelipase, ferrous sulfate, ferrous sulfate, furosemide, furosemide, acetaminophen, acetaminophen, lansoprazole, lansoprazole, cyanocobalamin, cyanocobalamin, cholecalciferol, cholecalciferol, phytonadione, phytonadione
Diazossido Disease Interaction
Moderate: arrhythmias, congestive heart failure, gout, pulmonary hypertension, renal impairment
Elimination Route
Readily absorbed following oral administration.
Half Life
28 ±8.3 hours in normal adults.
Elimination Route
Proglycem is extensively bound (more than 90%) to serum proteins, and is excreted in the kidneys.
Innovators Monograph
You find simplified version here Diazossido
