Dibro
Dibro Uses, Dosage, Side Effects, Food Interaction and all others data.
Dibro is a prodrug which is metabolized to rhein. It is currently approved in France for the treatment of osteoarthritis although the use of diacerein is restricted due to the side effects including severe diarrhea . Dibro is under investigation for the treatment of Insulin Resistance, Diabetes Mellitus (Type 2), and Diabetes-Related Complications.
Decreases inflammation and cartilage destruction and also corrects altered osteoblast acitivity .
| Trade Name | Dibro |
| Generic | Diacerein |
| Diacerein Other Names | Diacerein, Diacereína |
| Weight | 50mg |
| Type | Capsule |
| Formula | C19H12O8 |
| Weight | Average: 368.297 Monoisotopic: 368.053217346 |
| Protein binding | 99% of rhein is bound to plasma proteins . |
| Groups | Approved, Investigational |
| Therapeutic Class | |
| Manufacturer | Winbrain Research Laboratories |
| Available Country | Pakistan |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Dibro is an slow-onset anthraquinone IL-1 inhibitor used in the treatment of degenerative joint diseases like osteoarthritis.
For the treatment of osteoarthritis affecting the hip or knee .
Dibro is also used to associated treatment for these conditions: Osteoarthritis in the Hip Joint, Osteoarthritis of the Knee
How Dibro works
Dibro's active metabolite rhein Rhein reduces cartilage destruction by decreasing expression of matrix metalloproteinase (MMP)-1 and -3 as well as upregulating tissue inhibitor of matrix metalloproteinases which serve to reduce the activity of several MMPs . The anti-inflammatory action of rhein reduces the level of interleukin-1beta activity which plays a large role in reduction of extracellular matrix production, MMP activity, and continued inflammation . Rhein reduces abnormal osteoblast synthetic activity through an unknown mechanism .
Toxicity
Rhein Rhein has an oral LD50 of >5000mg/kg in mice. This is equivalent to a diacerein dose of >6476mg/kg.
Volume of Distribution
15-60L .
Elimination Route
Bioavailability of 50-60% . Entirely converted to the active metabolite rhein Rhein before reaching systemic circulation.
Half Life
4-10h .
Clearance
Total CL is 1.5L/h and renal CL is 0.1L/h .
Elimination Route
37% excreted in urine and 53% in feces as estimated in rats .
Innovators Monograph
You find simplified version here Dibro
FAQ
What is Dibro used for?
Dibro is a slow-acting medicine of the class anthraquinone used to treat joint diseases such as osteoarthritis.
How safe is Dibro?
Dibro is safe, apart from a substantially higher risk of diarrhoea, especially with longer-term use.Dibro has an acceptable safety profile, particularly in comparison with that of NSAIDs and paracetamol. The ESCEO positions Dibro as a first-line pharmacological background treatment of osteoarthritis.
How does Dibro work?
Dibro works by blocking the actions of interleukin-1 beta, a protein involved in the inflammation and destruction of cartilage that plays a role in the development of symptoms of degenerative joint diseases such as osteoarthritis.
What are the common side effects of Dibro?
Common side effects of Dibro are include:
- Diarrhoea.
- Stomach discomfort and pain.
- Nausea.
- Vomiting.
- Yellowing of skin and eyes.
- Urine discoloration.
- Increase in liver enzyme levels.
- Allergic skin reaction.
Is Dibro safe during pregnancy?
Dibro should not be administered during pregnancy.
Is Dibro safe during breastfeeding?
Dibro should not be administered during lactation.
Can I drink alcohol with Dibro?
Patients should be advised to limit their alcohol intake while on treatment with Dibro.
Can I drive after taking Dibro?
Dibro may cause dizziness and drowsiness. So if you observe such symptoms, then do not drive.
When should be taken of Dibro?
The recommended starting dose is 50 mg once daily with evening meal for the first 2 to 4 weeks of treatment, after which the recommended daily dose is 50 mg twice daily.
Can I take Dibro on an empty stomach?
The Dibro should be taken with food, one with breakfast and the other with evening meal.
How often can I take Dibro?
The recommended dose is 50 mg to be taken twice daily.
How long does Dibro take to work ?
Dibro starts showing its action in 2-3 hours. The duration of action of Dibro is 27 hours
How long can Dibro be taken?
The duration of action of Dibro is 27 hours.
Who should not take Dibro?
Dibro should not be used in any patient with liver disease or a history of liver disease, and doctors should be monitoring their patients for early signs of liver problems.
Is Dibro an antibiotic?
Dibro is a novel antibacterial agent; the antibacterial breakpoint could not be found in the literature or in standards.
What happen If I missed a dose of Dibro?
If you forget to take a dose of Dibro, make sure that you remember to take your next dose when it is due. Do not take two doses together to make up for a missed dose.
What happen if I overdose on Dibro?
Never take more than the prescribed dose. Seek emergency medical treatment or contact the doctor if you suspect that you might have taken an overdose of Dibro.
Can Dibro causes diarrhoea?
Dibro may cause diarrhoea or loose stools in the first few days of treatment. Contact your doctor if the diarrhoea does not stop within 3-4 days.
Who should not take Dibro?
Avoid taking Dibro if you are allergic to it. Seek medical attention if you notice any allergic reactions such as skin rash, hives (painful, itchy eruptions that sting), swelling (face, lips, tongue, etc.), breathing difficulty, etc. Dibro is excreted through the kidneys.
If you have pre-existing kidney problems, this medicine may accumulate in your kidneys and further worsen your condition. Hence, this medicine is not recommended for use if you have kidney problems.
Can Dibro affects my heart ?
Dibro Improves Left Ventricular Remodeling and Cardiac Function by Reducing the Inflammatory Response after Myocardial Infarction.
Does Dibro cause kidney damage?
Dibro has shown to be safe and effective in patients with moderate to severe renal impairment, and dose adjustment is not required in these patients.
Can Dibro affects my liver?
Around 0.5% of patients on Dibro had some kind of liver reaction, with most cases being mild, reversible increases in serum transaminases.
