Dicalcium Phosphate Dihydrate

Dicalcium Phosphate Dihydrate Uses, Dosage, Side Effects, Food Interaction and all others data.

Calcium phosphate reacts with acid in the stomach to raise the pH . In toothpaste it provides a source of calcium and phosphate ions to support remineralization of the teeth . As a supplement it provides a source of calcium and phospate, both of which are important ions in bone homeostasis.

Trade Name Dicalcium Phosphate Dihydrate
Generic Calcium phosphate dihydrate
Calcium phosphate dihydrate Other Names Calcium monohydrogen phosphate dihydrate, D.C.P., Dibasic calcium phosphate dihydrate, Dibasic calcium phosphate hydrate, Dicalcium phosphate dihydrate
Type
Formula CaH5O6P
Weight Average: 172.086
Monoisotopic: 171.9449658
Groups Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Dicalcium Phosphate Dihydrate
Dicalcium Phosphate Dihydrate

Uses

For use as an over the counter calcium and phosphate supplement, antacid, or a source of calcium and phosphate in toothpaste .

Dicalcium Phosphate Dihydrate is also used to associated treatment for these conditions: Dental cleaning

How Dicalcium Phosphate Dihydrate works

The phosphate ions in calcium phosphate likely react with hydrochloric acid in the stomach to neutralize the pH. In toothpaste and in systemic circulation, calcium phosphate provides a source of calcium and phosphate ions to support remineralization of the teeth and bone homeostasis respectively. The increase in plasma calcium reduces calcium flux from osteocyte activity by reducing the secretion of parathyroid hormone (PTH) . Calcium does this by stimulating a G-protein coupled calcium receptor on the surface of parathyroid cells. The reduction in calcium flux increases the amount of calcium deposited in bone resulting in an increase in bone mineral density. The reduction in PTH secretion also reduces the amount of vitamin D metabolized to its active form, calcidiol. Since calcidiol increases the expression of calcium dependent ATPases and transient receptor potential cation channel subfamily V member 6 (TRPV6) both of which are involved in calcium uptake from the gut, a reduction in calcidiol results in less calcium absorption. Additionally, TRPV5, the channel responsible for calcium reabsorption in the kidney, is downregulated when PTH secretion is reduced thus increasing calcium excretion via the kidneys. Another hormone, calitonin, is likely involved in the reduction of bone resorption during periods of high plasma calcium.

Food Interaction

No interactions found.

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