Dicewin
Dicewin Uses, Dosage, Side Effects, Food Interaction and all others data.
Dicewin is a prodrug which is metabolized to rhein. It is currently approved in France for the treatment of osteoarthritis although the use of diacerein is restricted due to the side effects including severe diarrhea . Dicewin is under investigation for the treatment of Insulin Resistance, Diabetes Mellitus (Type 2), and Diabetes-Related Complications.
Decreases inflammation and cartilage destruction and also corrects altered osteoblast acitivity .
| Trade Name | Dicewin |
| Generic | Diacerein |
| Diacerein Other Names | Diacerein, Diacereína |
| Weight | 50mg |
| Type | Capsule |
| Formula | C19H12O8 |
| Weight | Average: 368.297 Monoisotopic: 368.053217346 |
| Protein binding | 99% of rhein is bound to plasma proteins . |
| Groups | Approved, Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | India |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Dicewin is an slow-onset anthraquinone IL-1 inhibitor used in the treatment of degenerative joint diseases like osteoarthritis.
For the treatment of osteoarthritis affecting the hip or knee .
Dicewin is also used to associated treatment for these conditions: Osteoarthritis in the Hip Joint, Osteoarthritis of the Knee
How Dicewin works
Dicewin's active metabolite rhein Rhein reduces cartilage destruction by decreasing expression of matrix metalloproteinase (MMP)-1 and -3 as well as upregulating tissue inhibitor of matrix metalloproteinases which serve to reduce the activity of several MMPs . The anti-inflammatory action of rhein reduces the level of interleukin-1beta activity which plays a large role in reduction of extracellular matrix production, MMP activity, and continued inflammation . Rhein reduces abnormal osteoblast synthetic activity through an unknown mechanism .
Toxicity
Rhein Rhein has an oral LD50 of >5000mg/kg in mice. This is equivalent to a diacerein dose of >6476mg/kg.
Volume of Distribution
15-60L .
Elimination Route
Bioavailability of 50-60% . Entirely converted to the active metabolite rhein Rhein before reaching systemic circulation.
Half Life
4-10h .
Clearance
Total CL is 1.5L/h and renal CL is 0.1L/h .
Elimination Route
37% excreted in urine and 53% in feces as estimated in rats .
Innovators Monograph
You find simplified version here Dicewin
FAQ
What is Dicewin used for?
Dicewin is a slow-acting medicine of the class anthraquinone used to treat joint diseases such as osteoarthritis.
How safe is Dicewin?
Dicewin is safe, apart from a substantially higher risk of diarrhoea, especially with longer-term use.Dicewin has an acceptable safety profile, particularly in comparison with that of NSAIDs and paracetamol. The ESCEO positions Dicewin as a first-line pharmacological background treatment of osteoarthritis.
How does Dicewin work?
Dicewin works by blocking the actions of interleukin-1 beta, a protein involved in the inflammation and destruction of cartilage that plays a role in the development of symptoms of degenerative joint diseases such as osteoarthritis.
What are the common side effects of Dicewin?
Common side effects of Dicewin are include:
- Diarrhoea.
- Stomach discomfort and pain.
- Nausea.
- Vomiting.
- Yellowing of skin and eyes.
- Urine discoloration.
- Increase in liver enzyme levels.
- Allergic skin reaction.
Is Dicewin safe during pregnancy?
Dicewin should not be administered during pregnancy.
Is Dicewin safe during breastfeeding?
Dicewin should not be administered during lactation.
Can I drink alcohol with Dicewin?
Patients should be advised to limit their alcohol intake while on treatment with Dicewin.
Can I drive after taking Dicewin?
Dicewin may cause dizziness and drowsiness. So if you observe such symptoms, then do not drive.
When should be taken of Dicewin?
The recommended starting dose is 50 mg once daily with evening meal for the first 2 to 4 weeks of treatment, after which the recommended daily dose is 50 mg twice daily.
Can I take Dicewin on an empty stomach?
The Dicewin should be taken with food, one with breakfast and the other with evening meal.
How often can I take Dicewin?
The recommended dose is 50 mg to be taken twice daily.
How long does Dicewin take to work ?
Dicewin starts showing its action in 2-3 hours. The duration of action of Dicewin is 27 hours
How long can Dicewin be taken?
The duration of action of Dicewin is 27 hours.
Who should not take Dicewin?
Dicewin should not be used in any patient with liver disease or a history of liver disease, and doctors should be monitoring their patients for early signs of liver problems.
Is Dicewin an antibiotic?
Dicewin is a novel antibacterial agent; the antibacterial breakpoint could not be found in the literature or in standards.
What happen If I missed a dose of Dicewin?
If you forget to take a dose of Dicewin, make sure that you remember to take your next dose when it is due. Do not take two doses together to make up for a missed dose.
What happen if I overdose on Dicewin?
Never take more than the prescribed dose. Seek emergency medical treatment or contact the doctor if you suspect that you might have taken an overdose of Dicewin.
Can Dicewin causes diarrhoea?
Dicewin may cause diarrhoea or loose stools in the first few days of treatment. Contact your doctor if the diarrhoea does not stop within 3-4 days.
Who should not take Dicewin?
Avoid taking Dicewin if you are allergic to it. Seek medical attention if you notice any allergic reactions such as skin rash, hives (painful, itchy eruptions that sting), swelling (face, lips, tongue, etc.), breathing difficulty, etc. Dicewin is excreted through the kidneys.
If you have pre-existing kidney problems, this medicine may accumulate in your kidneys and further worsen your condition. Hence, this medicine is not recommended for use if you have kidney problems.
Can Dicewin affects my heart ?
Dicewin Improves Left Ventricular Remodeling and Cardiac Function by Reducing the Inflammatory Response after Myocardial Infarction.
Does Dicewin cause kidney damage?
Dicewin has shown to be safe and effective in patients with moderate to severe renal impairment, and dose adjustment is not required in these patients.
Can Dicewin affects my liver?
Around 0.5% of patients on Dicewin had some kind of liver reaction, with most cases being mild, reversible increases in serum transaminases.
